ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy

Acute ischemic stroke is a devastating disease with very limited therapeutics. Growing appreciation of dysregulated autophagy contributes to the progression of brain ischemic injury, making it to be an appealing intervention target. In terms of its well-characterized consequences, the signal molecul...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2020-10, Vol.33 (4), p.1046-1055
Hauptverfasser:	Zhang, Beilin, Deng, Fang, Zhou, Chunkui, Fang, Shaokuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy - genetics Autophagy - physiology Beclin-1 - metabolism Biomedical and Life Sciences Brain injury Brain Ischemia - genetics Brain Ischemia - prevention & control Cell Biology Chloride Channels - metabolism Chloride Channels - physiology Class III Phosphatidylinositol 3-Kinases - metabolism Gynecology Ischemia Life Sciences Male Neuroprotection Neuroprotective Agents Oncology Phagocytosis Rats, Sprague-Dawley Reperfusion Reperfusion Injury - genetics Reperfusion Injury - prevention & control Reproductive Medicine Research Article Stem Cells Stroke - genetics Stroke - prevention & control Surgery Up-Regulation - genetics
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