Kidney exchange strategies: new aspects and applications with a focus on deceased donor‐initiated chains
Summary Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus...
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| Veröffentlicht in: | Transplant international 2020-10, Vol.33 (10), p.1177-1184 |
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| creator | Furian, Lucrezia Nicolò, Antonio Di Bella, Caterina Cardillo, Massimo Cozzi, Emanuele Rigotti, Paolo |
| description | Summary
Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus on advanced KPD strategies, including the most recent idea of initiating living donor (LD) transplantation chains with a deceased donor (DD) kidney, first applied successfully in 2018. Since then, Italy has been running a national programme in which a chain‐initiating kidney is selected from a DD pool and allocated to a recipient with an incompatible LD, and the LD’s kidney is transplanted into a patient on the waiting list (WL). At this stage, since the ethical and logistic issues have been managed appropriately, KPD starting with a DD has proved to be a feasible strategy. It enables transplants in recipients of incompatible pairs without the need for desensitizing and also benefits patients on the WL who are allocated chain‐ending kidneys from LDs (prioritizing sensitized patients and those on the WL for longer). |
| doi_str_mv | 10.1111/tri.13712 |
| format | Article |
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Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus on advanced KPD strategies, including the most recent idea of initiating living donor (LD) transplantation chains with a deceased donor (DD) kidney, first applied successfully in 2018. Since then, Italy has been running a national programme in which a chain‐initiating kidney is selected from a DD pool and allocated to a recipient with an incompatible LD, and the LD’s kidney is transplanted into a patient on the waiting list (WL). At this stage, since the ethical and logistic issues have been managed appropriately, KPD starting with a DD has proved to be a feasible strategy. It enables transplants in recipients of incompatible pairs without the need for desensitizing and also benefits patients on the WL who are allocated chain‐ending kidneys from LDs (prioritizing sensitized patients and those on the WL for longer).</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.13712</identifier><identifier>PMID: 32772429</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>advanced kidney paired donation ; Chains ; deceased donor‐initiated domino chains ; Desensitization ; domino‐paired chains ; Immunology ; Incompatibility ; incompatible pairs ; Kidney transplantation ; Kidneys ; living kidney donor ; State-of-the-art reviews ; Transplantation ; Transplants ; Transplants & implants</subject><ispartof>Transplant international, 2020-10, Vol.33 (10), p.1177-1184</ispartof><rights>2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><rights>2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-cab2ee10ae9b88b83553107376a362c7d1039f85c77c1a5ef1dffe3f4be506d43</citedby><cites>FETCH-LOGICAL-c3532-cab2ee10ae9b88b83553107376a362c7d1039f85c77c1a5ef1dffe3f4be506d43</cites><orcidid>0000-0002-2264-7986</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.13712$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.13712$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32772429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furian, Lucrezia</creatorcontrib><creatorcontrib>Nicolò, Antonio</creatorcontrib><creatorcontrib>Di Bella, Caterina</creatorcontrib><creatorcontrib>Cardillo, Massimo</creatorcontrib><creatorcontrib>Cozzi, Emanuele</creatorcontrib><creatorcontrib>Rigotti, Paolo</creatorcontrib><title>Kidney exchange strategies: new aspects and applications with a focus on deceased donor‐initiated chains</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus on advanced KPD strategies, including the most recent idea of initiating living donor (LD) transplantation chains with a deceased donor (DD) kidney, first applied successfully in 2018. Since then, Italy has been running a national programme in which a chain‐initiating kidney is selected from a DD pool and allocated to a recipient with an incompatible LD, and the LD’s kidney is transplanted into a patient on the waiting list (WL). At this stage, since the ethical and logistic issues have been managed appropriately, KPD starting with a DD has proved to be a feasible strategy. It enables transplants in recipients of incompatible pairs without the need for desensitizing and also benefits patients on the WL who are allocated chain‐ending kidneys from LDs (prioritizing sensitized patients and those on the WL for longer).</description><subject>advanced kidney paired donation</subject><subject>Chains</subject><subject>deceased donor‐initiated domino chains</subject><subject>Desensitization</subject><subject>domino‐paired chains</subject><subject>Immunology</subject><subject>Incompatibility</subject><subject>incompatible pairs</subject><subject>Kidney transplantation</subject><subject>Kidneys</subject><subject>living kidney donor</subject><subject>State-of-the-art reviews</subject><subject>Transplantation</subject><subject>Transplants</subject><subject>Transplants & implants</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kctKxDAUhoMoOl4WvoAE3OhiNLc2rTsZvKEgiK5Lmpxqhk5Sk5Zxdj6Cz-iTGB11IXg2Z3E-Pn7Oj9AuJUc0zXEf7BHlkrIVNKKCszFjUq6iESm5GJNCig20GeOUEMKKjKyjDZ7uTLByhKbX1jhYYHjRT8o9Ao59UD08Wogn2MEcq9iB7iNWzmDVda3VqrfeRTy3_RNWuPF6iNg7bECDimCw8c6H99c362xvk8vgpLYubqO1RrURdr73Fno4P7ufXI5vbi-uJqc3Y82zlF2rmgFQoqCsi6IueJZxSiSXueI509JQwsumyLSUmqoMGmqaBngjashIbgTfQgdLbxf88wCxr2Y2amhb5cAPsWLpQ4KTrCQJ3f-DTv0QXEqXKMGLvBA5TdThktLBxxigqbpgZyosKkqqzwKqVED1VUBi976NQz0D80v-fDwBx0tgbltY_G-q7u-ulsoPEs6Q8A</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Furian, Lucrezia</creator><creator>Nicolò, Antonio</creator><creator>Di Bella, Caterina</creator><creator>Cardillo, Massimo</creator><creator>Cozzi, Emanuele</creator><creator>Rigotti, Paolo</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2264-7986</orcidid></search><sort><creationdate>202010</creationdate><title>Kidney exchange strategies: new aspects and applications with a focus on deceased donor‐initiated chains</title><author>Furian, Lucrezia ; Nicolò, Antonio ; Di Bella, Caterina ; Cardillo, Massimo ; Cozzi, Emanuele ; Rigotti, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-cab2ee10ae9b88b83553107376a362c7d1039f85c77c1a5ef1dffe3f4be506d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>advanced kidney paired donation</topic><topic>Chains</topic><topic>deceased donor‐initiated domino chains</topic><topic>Desensitization</topic><topic>domino‐paired chains</topic><topic>Immunology</topic><topic>Incompatibility</topic><topic>incompatible pairs</topic><topic>Kidney transplantation</topic><topic>Kidneys</topic><topic>living kidney donor</topic><topic>State-of-the-art reviews</topic><topic>Transplantation</topic><topic>Transplants</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furian, Lucrezia</creatorcontrib><creatorcontrib>Nicolò, Antonio</creatorcontrib><creatorcontrib>Di Bella, Caterina</creatorcontrib><creatorcontrib>Cardillo, Massimo</creatorcontrib><creatorcontrib>Cozzi, Emanuele</creatorcontrib><creatorcontrib>Rigotti, Paolo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furian, Lucrezia</au><au>Nicolò, Antonio</au><au>Di Bella, Caterina</au><au>Cardillo, Massimo</au><au>Cozzi, Emanuele</au><au>Rigotti, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kidney exchange strategies: new aspects and applications with a focus on deceased donor‐initiated chains</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2020-10</date><risdate>2020</risdate><volume>33</volume><issue>10</issue><spage>1177</spage><epage>1184</epage><pages>1177-1184</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
Kidney paired donation (KPD) is a valuable way to overcome immunological incompatibility in the context of living donation, and several strategies have been implemented to boost its development. In this article, we reviewed the current state of the art in this field, with a particular focus on advanced KPD strategies, including the most recent idea of initiating living donor (LD) transplantation chains with a deceased donor (DD) kidney, first applied successfully in 2018. Since then, Italy has been running a national programme in which a chain‐initiating kidney is selected from a DD pool and allocated to a recipient with an incompatible LD, and the LD’s kidney is transplanted into a patient on the waiting list (WL). At this stage, since the ethical and logistic issues have been managed appropriately, KPD starting with a DD has proved to be a feasible strategy. It enables transplants in recipients of incompatible pairs without the need for desensitizing and also benefits patients on the WL who are allocated chain‐ending kidneys from LDs (prioritizing sensitized patients and those on the WL for longer).</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32772429</pmid><doi>10.1111/tri.13712</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2264-7986</orcidid></addata></record> |
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| ispartof | Transplant international, 2020-10, Vol.33 (10), p.1177-1184 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals |
| subjects | advanced kidney paired donation Chains deceased donor‐initiated domino chains Desensitization domino‐paired chains Immunology Incompatibility incompatible pairs Kidney transplantation Kidneys living kidney donor State-of-the-art reviews Transplantation Transplants Transplants & implants |
| title | Kidney exchange strategies: new aspects and applications with a focus on deceased donor‐initiated chains |
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