Lesions and Cellular Tropism of Natural Rift Valley Fever Virus Infection in Young Lambs

A clear distinction can be made regarding the susceptibility to and the severity of lesions in young lambs when compared to adult sheep. In particular, there are important differences in the lesions and tropism of Rift Valley fever virus (RVFV) in the liver, kidneys, and lymphoid tissues of young la...

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Veröffentlicht in:	Veterinary pathology 2020-01, Vol.57 (1), p.66-81
Hauptverfasser:	Odendaal, Lieza, Davis, A. Sally, Fosgate, Geoffrey T., Clift, Sarah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Age Factors animal pathology Animals Animals, Newborn Antibodies, Viral - immunology Antigens, Viral - immunology blood cardiomyocytes cytoplasm death Disease Outbreaks - veterinary epithelium hepatitis hepatocytes histopathology immunohistochemistry Immunohistochemistry - veterinary Kidney - pathology Kidney - virology kidneys liver Liver - pathology Liver - virology Lung - pathology Lung - virology macrophages necrosis Organ Specificity Rift Valley fever Rift Valley Fever - diagnosis Rift Valley Fever - epidemiology Rift Valley Fever - pathology Rift Valley Fever - virology Rift Valley fever phlebovirus Rift Valley fever virus - immunology Rift Valley fever virus - physiology Sheep Sheep Diseases - diagnosis Sheep Diseases - epidemiology Sheep Diseases - pathology Sheep Diseases - virology smooth muscle South Africa South Africa - epidemiology spleen Spleen - pathology Spleen - virology Tropism viral antigens
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Beschreibung
Zusammenfassung:	A clear distinction can be made regarding the susceptibility to and the severity of lesions in young lambs when compared to adult sheep. In particular, there are important differences in the lesions and tropism of Rift Valley fever virus (RVFV) in the liver, kidneys, and lymphoid tissues of young lambs. A total of 84 lambs (
ISSN:	0300-9858 1544-2217 1544-2217
DOI:	10.1177/0300985819882633