Soluble PD-L1 and Circulating CD8+PD-1+ and NK Cells Enclose a Prognostic and Predictive Immune Effector Score in Immunotherapy Treated NSCLC patients

•Immune checkpoint inhibitors (ICIs) have shifted the therapeutic approach to NSCLC•Reproducible biomarkers of ICI benefit represent an unmet and urgent need•Circulating descriptors of cancer-host immune interaction were explored here•sPD-L1, CD8+PD-1+ and NK cells enclosed a highly prognostic immun...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2020-10, Vol.148, p.1-11
Hauptverfasser:	Mazzaschi, G., Minari, R., Zecca, A., Cavazzoni, A., Ferri, V., Mori, C., Squadrilli, A., Bordi, P., Buti, S., Bersanelli, M., Leonetti, A., Cosenza, A, Ferri, L., Rapacchi, E., Missale, G., Petronini, P.G., Quaini, F., Tiseo, M
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen Carcinoma, Non-Small-Cell Lung - therapy CD8-Positive T-Lymphocytes circulating biomarkers Humans immune checkpoint inhibitors Immunotherapy Killer Cells, Natural Lung Neoplasms - therapy non-small cell lung cancer Prognosis prognostic scores Programmed Cell Death 1 Receptor
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