Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers
•The adapted method of changing animals’ home cage during experiment was tested for suitability in animal based experiment.•The method allowed variation in markers for oxidative stress and inflammation.•Frequent exposure to varied home cage sizes decreased pain sensitivity to noxious thermal-, chemi...
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| Veröffentlicht in: | Journal of neuroscience methods 2020-11, Vol.345, p.108890-108890, Article 108890 |
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| creator | Oyewole, Aboyeji Lukuman Oyafemi, Kehinde Olumide Badmus, Kolade Samson Omoleye, Janet Omotola Abubakar, Midrar Folahanmi Adeniyi-Raheem, Omolade Amedu, Abdul-hameed Lawal, Dolapo Latifah Ijiyode, Aishat Oluwakemi Yussuf, Ateeqah Oreoluwa Ishola, Solomon Sunday Sulaimon, Fatimo Ajoke Alli-Oluwafuyi, Abdulmusawwir O. Nafiu, Abdulrazaq Bidemi Akinola, Olugbenga Olajide, Olayemi Joseph Amin, Abdulbasit Abdulmajeed, Wahab Imam Michael, Olugbenga Samuel Adeyanju, Oluwaseun Aremu Ogunjimi, Gbowoloye Lanre |
| description | •The adapted method of changing animals’ home cage during experiment was tested for suitability in animal based experiment.•The method allowed variation in markers for oxidative stress and inflammation.•Frequent exposure to varied home cage sizes decreased pain sensitivity to noxious thermal-, chemical- and mechanical-stimulus.•This adapted procedure could lead to false results, thus affecting accuracy and reproducibility in animal based experiment.
Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animal-based experiments.
Here, two groups of male Swiss mice (Control group – Cage stationed, and Test group – Cage migrated) were used for this study. The cage-migrated mice were exposed daily to various cage sizes used across laboratories in Nigeria while the cage-stationed mice exposed daily to different but the same cage size and shape. At the end of the 30 days exposure, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of histological and biochemical metrics.
The study showed a significant (p |
| doi_str_mv | 10.1016/j.jneumeth.2020.108890 |
| format | Article |
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Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animal-based experiments.
Here, two groups of male Swiss mice (Control group – Cage stationed, and Test group – Cage migrated) were used for this study. The cage-migrated mice were exposed daily to various cage sizes used across laboratories in Nigeria while the cage-stationed mice exposed daily to different but the same cage size and shape. At the end of the 30 days exposure, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of histological and biochemical metrics.
The study showed a significant (p < 0.05) decrease in blood glucose levels (at 60 and 120 min of oral glucose tolerance test) in the cage-migrated mice compared to cage-stationed mice. Strikingly, peripheral oxidative stress (plasma malondialdehyde) and pain sensitivity (formalin test, hot-and-cold plate test, and von Frey test) decreased significantly in cage-migrated mice compared to cage-stationed animals. Also, the pro-inflammation mediators (IL-6 and NF-κB) increased significantly in cage-migrated mice compared to cage-stationed mice. However, emotion-linked behaviours, neurotransmitters (serotonin, noradrenaline and GABA), brain and plasma electrolytes were not significantly difference in cage-migrated animals compared to cage-stationed mice.
Taken together, these results suggest that varied size cage-to-cage exposure of experimental mice could affect targeted behavioural and biomolecular parameters of pain and inflammation, thus diminishing research reproducibility, precipitating false negative/positive results and leading to poor translational outcomes.</description><identifier>ISSN: 0165-0270</identifier><identifier>EISSN: 1872-678X</identifier><identifier>DOI: 10.1016/j.jneumeth.2020.108890</identifier><identifier>PMID: 32768413</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cage ; Habitat method ; Inflammation ; Pain sensitivity</subject><ispartof>Journal of neuroscience methods, 2020-11, Vol.345, p.108890-108890, Article 108890</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-e590dd4c0eb93173ea420e109274e8aab988a1bfcf490c04e7146a6dab8bfd2d3</citedby><cites>FETCH-LOGICAL-c368t-e590dd4c0eb93173ea420e109274e8aab988a1bfcf490c04e7146a6dab8bfd2d3</cites><orcidid>0000-0001-6777-4201</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneumeth.2020.108890$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32768413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oyewole, Aboyeji Lukuman</creatorcontrib><creatorcontrib>Oyafemi, Kehinde Olumide</creatorcontrib><creatorcontrib>Badmus, Kolade Samson</creatorcontrib><creatorcontrib>Omoleye, Janet Omotola</creatorcontrib><creatorcontrib>Abubakar, Midrar Folahanmi</creatorcontrib><creatorcontrib>Adeniyi-Raheem, Omolade</creatorcontrib><creatorcontrib>Amedu, Abdul-hameed</creatorcontrib><creatorcontrib>Lawal, Dolapo Latifah</creatorcontrib><creatorcontrib>Ijiyode, Aishat Oluwakemi</creatorcontrib><creatorcontrib>Yussuf, Ateeqah Oreoluwa</creatorcontrib><creatorcontrib>Ishola, Solomon Sunday</creatorcontrib><creatorcontrib>Sulaimon, Fatimo Ajoke</creatorcontrib><creatorcontrib>Alli-Oluwafuyi, Abdulmusawwir O.</creatorcontrib><creatorcontrib>Nafiu, Abdulrazaq Bidemi</creatorcontrib><creatorcontrib>Akinola, Olugbenga</creatorcontrib><creatorcontrib>Olajide, Olayemi Joseph</creatorcontrib><creatorcontrib>Amin, Abdulbasit</creatorcontrib><creatorcontrib>Abdulmajeed, Wahab Imam</creatorcontrib><creatorcontrib>Michael, Olugbenga Samuel</creatorcontrib><creatorcontrib>Adeyanju, Oluwaseun Aremu</creatorcontrib><creatorcontrib>Ogunjimi, Gbowoloye Lanre</creatorcontrib><title>Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers</title><title>Journal of neuroscience methods</title><addtitle>J Neurosci Methods</addtitle><description>•The adapted method of changing animals’ home cage during experiment was tested for suitability in animal based experiment.•The method allowed variation in markers for oxidative stress and inflammation.•Frequent exposure to varied home cage sizes decreased pain sensitivity to noxious thermal-, chemical- and mechanical-stimulus.•This adapted procedure could lead to false results, thus affecting accuracy and reproducibility in animal based experiment.
Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animal-based experiments.
Here, two groups of male Swiss mice (Control group – Cage stationed, and Test group – Cage migrated) were used for this study. The cage-migrated mice were exposed daily to various cage sizes used across laboratories in Nigeria while the cage-stationed mice exposed daily to different but the same cage size and shape. At the end of the 30 days exposure, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of histological and biochemical metrics.
The study showed a significant (p < 0.05) decrease in blood glucose levels (at 60 and 120 min of oral glucose tolerance test) in the cage-migrated mice compared to cage-stationed mice. Strikingly, peripheral oxidative stress (plasma malondialdehyde) and pain sensitivity (formalin test, hot-and-cold plate test, and von Frey test) decreased significantly in cage-migrated mice compared to cage-stationed animals. Also, the pro-inflammation mediators (IL-6 and NF-κB) increased significantly in cage-migrated mice compared to cage-stationed mice. However, emotion-linked behaviours, neurotransmitters (serotonin, noradrenaline and GABA), brain and plasma electrolytes were not significantly difference in cage-migrated animals compared to cage-stationed mice.
Taken together, these results suggest that varied size cage-to-cage exposure of experimental mice could affect targeted behavioural and biomolecular parameters of pain and inflammation, thus diminishing research reproducibility, precipitating false negative/positive results and leading to poor translational outcomes.</description><subject>Cage</subject><subject>Habitat method</subject><subject>Inflammation</subject><subject>Pain sensitivity</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkMFO3DAQhq2KqmxpXwH5yCWL7XgT5wZC0CIh9dJKvVkTe1K8JHawnRXbp8erhV57sjT6_hn_HyHnnK05483ldr31uEyYH9eCicNQqY59ICuuWlE1rfp9QlYF3FRMtOyUfE5pyxiTHWs-kdNatI2SvF6R-S7i84I-U3yZQ1oi0hzoDqJDSx_DhNTAH6TJ_cVEYcwYE53BeZrQJ5fdzuU9BW9pOrBPuKfODyNME2QXfBVxhFw29S5MEJ9K-gv5OMCY8Ovbe0Z-3d3-vPlePfz4dn9z_VCZulG5wk3HrJWGYd_VvK0RpGDIWSdaiQqg75QC3g9mKJUMk9hy2UBjoVf9YIWtz8jFce8cQymYsp5cMjiO4DEsSQtZcyXkhvGCNkfUxJBSxEHP0ZXv7jVn-mBbb_W7bX2wrY-2S_D87cbST2j_xd71FuDqCGBpunMYdTIOvUHrIpqsbXD_u_EK8uaXSg</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Oyewole, Aboyeji Lukuman</creator><creator>Oyafemi, Kehinde Olumide</creator><creator>Badmus, Kolade Samson</creator><creator>Omoleye, Janet Omotola</creator><creator>Abubakar, Midrar Folahanmi</creator><creator>Adeniyi-Raheem, Omolade</creator><creator>Amedu, Abdul-hameed</creator><creator>Lawal, Dolapo Latifah</creator><creator>Ijiyode, Aishat Oluwakemi</creator><creator>Yussuf, Ateeqah Oreoluwa</creator><creator>Ishola, Solomon Sunday</creator><creator>Sulaimon, Fatimo Ajoke</creator><creator>Alli-Oluwafuyi, Abdulmusawwir O.</creator><creator>Nafiu, Abdulrazaq Bidemi</creator><creator>Akinola, Olugbenga</creator><creator>Olajide, Olayemi Joseph</creator><creator>Amin, Abdulbasit</creator><creator>Abdulmajeed, Wahab Imam</creator><creator>Michael, Olugbenga Samuel</creator><creator>Adeyanju, Oluwaseun Aremu</creator><creator>Ogunjimi, Gbowoloye Lanre</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6777-4201</orcidid></search><sort><creationdate>20201101</creationdate><title>Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers</title><author>Oyewole, Aboyeji Lukuman ; Oyafemi, Kehinde Olumide ; Badmus, Kolade Samson ; Omoleye, Janet Omotola ; Abubakar, Midrar Folahanmi ; Adeniyi-Raheem, Omolade ; Amedu, Abdul-hameed ; Lawal, Dolapo Latifah ; Ijiyode, Aishat Oluwakemi ; Yussuf, Ateeqah Oreoluwa ; Ishola, Solomon Sunday ; Sulaimon, Fatimo Ajoke ; Alli-Oluwafuyi, Abdulmusawwir O. ; Nafiu, Abdulrazaq Bidemi ; Akinola, Olugbenga ; Olajide, Olayemi Joseph ; Amin, Abdulbasit ; Abdulmajeed, Wahab Imam ; Michael, Olugbenga Samuel ; Adeyanju, Oluwaseun Aremu ; Ogunjimi, Gbowoloye Lanre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-e590dd4c0eb93173ea420e109274e8aab988a1bfcf490c04e7146a6dab8bfd2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cage</topic><topic>Habitat method</topic><topic>Inflammation</topic><topic>Pain sensitivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oyewole, Aboyeji Lukuman</creatorcontrib><creatorcontrib>Oyafemi, Kehinde Olumide</creatorcontrib><creatorcontrib>Badmus, Kolade Samson</creatorcontrib><creatorcontrib>Omoleye, Janet Omotola</creatorcontrib><creatorcontrib>Abubakar, Midrar Folahanmi</creatorcontrib><creatorcontrib>Adeniyi-Raheem, Omolade</creatorcontrib><creatorcontrib>Amedu, Abdul-hameed</creatorcontrib><creatorcontrib>Lawal, Dolapo Latifah</creatorcontrib><creatorcontrib>Ijiyode, Aishat Oluwakemi</creatorcontrib><creatorcontrib>Yussuf, Ateeqah Oreoluwa</creatorcontrib><creatorcontrib>Ishola, Solomon Sunday</creatorcontrib><creatorcontrib>Sulaimon, Fatimo Ajoke</creatorcontrib><creatorcontrib>Alli-Oluwafuyi, Abdulmusawwir O.</creatorcontrib><creatorcontrib>Nafiu, Abdulrazaq Bidemi</creatorcontrib><creatorcontrib>Akinola, Olugbenga</creatorcontrib><creatorcontrib>Olajide, Olayemi Joseph</creatorcontrib><creatorcontrib>Amin, Abdulbasit</creatorcontrib><creatorcontrib>Abdulmajeed, Wahab Imam</creatorcontrib><creatorcontrib>Michael, Olugbenga Samuel</creatorcontrib><creatorcontrib>Adeyanju, Oluwaseun Aremu</creatorcontrib><creatorcontrib>Ogunjimi, Gbowoloye Lanre</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oyewole, Aboyeji Lukuman</au><au>Oyafemi, Kehinde Olumide</au><au>Badmus, Kolade Samson</au><au>Omoleye, Janet Omotola</au><au>Abubakar, Midrar Folahanmi</au><au>Adeniyi-Raheem, Omolade</au><au>Amedu, Abdul-hameed</au><au>Lawal, Dolapo Latifah</au><au>Ijiyode, Aishat Oluwakemi</au><au>Yussuf, Ateeqah Oreoluwa</au><au>Ishola, Solomon Sunday</au><au>Sulaimon, Fatimo Ajoke</au><au>Alli-Oluwafuyi, Abdulmusawwir O.</au><au>Nafiu, Abdulrazaq Bidemi</au><au>Akinola, Olugbenga</au><au>Olajide, Olayemi Joseph</au><au>Amin, Abdulbasit</au><au>Abdulmajeed, Wahab Imam</au><au>Michael, Olugbenga Samuel</au><au>Adeyanju, Oluwaseun Aremu</au><au>Ogunjimi, Gbowoloye Lanre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>345</volume><spage>108890</spage><epage>108890</epage><pages>108890-108890</pages><artnum>108890</artnum><issn>0165-0270</issn><eissn>1872-678X</eissn><abstract>•The adapted method of changing animals’ home cage during experiment was tested for suitability in animal based experiment.•The method allowed variation in markers for oxidative stress and inflammation.•Frequent exposure to varied home cage sizes decreased pain sensitivity to noxious thermal-, chemical- and mechanical-stimulus.•This adapted procedure could lead to false results, thus affecting accuracy and reproducibility in animal based experiment.
Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animal-based experiments.
Here, two groups of male Swiss mice (Control group – Cage stationed, and Test group – Cage migrated) were used for this study. The cage-migrated mice were exposed daily to various cage sizes used across laboratories in Nigeria while the cage-stationed mice exposed daily to different but the same cage size and shape. At the end of the 30 days exposure, top-rated paradigms were used to profile changes in physiological behaviours, and this was followed by evaluation of histological and biochemical metrics.
The study showed a significant (p < 0.05) decrease in blood glucose levels (at 60 and 120 min of oral glucose tolerance test) in the cage-migrated mice compared to cage-stationed mice. Strikingly, peripheral oxidative stress (plasma malondialdehyde) and pain sensitivity (formalin test, hot-and-cold plate test, and von Frey test) decreased significantly in cage-migrated mice compared to cage-stationed animals. Also, the pro-inflammation mediators (IL-6 and NF-κB) increased significantly in cage-migrated mice compared to cage-stationed mice. However, emotion-linked behaviours, neurotransmitters (serotonin, noradrenaline and GABA), brain and plasma electrolytes were not significantly difference in cage-migrated animals compared to cage-stationed mice.
Taken together, these results suggest that varied size cage-to-cage exposure of experimental mice could affect targeted behavioural and biomolecular parameters of pain and inflammation, thus diminishing research reproducibility, precipitating false negative/positive results and leading to poor translational outcomes.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32768413</pmid><doi>10.1016/j.jneumeth.2020.108890</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6777-4201</orcidid></addata></record> |
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| subjects | Cage Habitat method Inflammation Pain sensitivity |
| title | Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers |
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