Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?

Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medulla...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Laryngoscope 2021-02, Vol.131 (2), p.E677-E681
Hauptverfasser: Muallem Kalmovich, Limor, Jabarin, Basel, Koren, Shlomit, Or, Karen, Marcus, Efrat, Tkacheva, Inna, Benbassat, Carlos, Steinschneider, Miriam
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page E681
container_issue 2
container_start_page E677
container_title The Laryngoscope
container_volume 131
creator Muallem Kalmovich, Limor
Jabarin, Basel
Koren, Shlomit
Or, Karen
Marcus, Efrat
Tkacheva, Inna
Benbassat, Carlos
Steinschneider, Miriam
description Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow‐up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with ≥2 (n = 34) versus ≥3 (n = 13) first‐relative affected members. Results There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the ≥3‐member group were 25% and 8.3% compared to 0% and 0% in the two‐member group (P = .02 and P = ns, respectively). Also, LN involvement was significantly higher in the ≥3‐member group (61.6% vs. 24.2%, respectively; P = .036). Conclusion FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the ≥3‐affected‐relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked. Level of Evidence 3/5 Laryngoscope, 131:E677–E681, 2021
doi_str_mv 10.1002/lary.28989
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2431817751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2431817751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3579-7b0603ff2cb505ed157108f0d8b3dea885904804e5846f134e7b98124b185ddd3</originalsourceid><addsrcrecordid>eNp9kEFLwzAcR4Mobk4vfgAJeBGhM2maJjlJGU4HU1Em6Cm0TTo72mUmVum3N7XTgwdPOfwfj18eAMcYjTFC4UWV2nYccsHFDhhiSnAQCUF3wdAfScBp-DwAB86tEMKMULQPBiRkMeY4HIKHmYPTtC6rMq3gnVnXWjVVJ4SL19aaUsFJus61hQm8NVbDZLm02rnyQ8NFu9HQFH_Ay0OwV6SV00fbdwSepleLyU0wv7-eTZJ5kBPKRMAyFCNSFGGeUUS1wpRhxAukeEaUTjmnAkUcRZryKC4wiTTLhJ8cZZhTpRQZgbPeu7HmrdHuXdaly7Ufv9amcTKMiP8iYxR79PQPujKNXft1nmIx50TEHXXeU7k1zlldyI0ta59CYiS70LLrIr9De_hkq2wy3-wX_SnrAdwDn2Wl239Ucp48vvTSL92Jhmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2476883961</pqid></control><display><type>article</type><title>Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Muallem Kalmovich, Limor ; Jabarin, Basel ; Koren, Shlomit ; Or, Karen ; Marcus, Efrat ; Tkacheva, Inna ; Benbassat, Carlos ; Steinschneider, Miriam</creator><creatorcontrib>Muallem Kalmovich, Limor ; Jabarin, Basel ; Koren, Shlomit ; Or, Karen ; Marcus, Efrat ; Tkacheva, Inna ; Benbassat, Carlos ; Steinschneider, Miriam</creatorcontrib><description>Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow‐up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with ≥2 (n = 34) versus ≥3 (n = 13) first‐relative affected members. Results There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the ≥3‐member group were 25% and 8.3% compared to 0% and 0% in the two‐member group (P = .02 and P = ns, respectively). Also, LN involvement was significantly higher in the ≥3‐member group (61.6% vs. 24.2%, respectively; P = .036). Conclusion FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the ≥3‐affected‐relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked. Level of Evidence 3/5 Laryngoscope, 131:E677–E681, 2021</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.28989</identifier><identifier>PMID: 32761812</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; familial non‐medullary thyroid cancer ; Female ; Humans ; Laryngoscopy ; Male ; Middle Aged ; prognosis ; Retrospective Studies ; Sex Factors ; survival ; Thyroid cancer ; Thyroid Cancer, Papillary - diagnosis ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid Gland - pathology ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Treatment Outcome ; Young Adult</subject><ispartof>The Laryngoscope, 2021-02, Vol.131 (2), p.E677-E681</ispartof><rights>2020 American Laryngological, Rhinological and Otological Society Inc</rights><rights>2020 American Laryngological, Rhinological and Otological Society Inc.</rights><rights>2021 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-7b0603ff2cb505ed157108f0d8b3dea885904804e5846f134e7b98124b185ddd3</citedby><cites>FETCH-LOGICAL-c3579-7b0603ff2cb505ed157108f0d8b3dea885904804e5846f134e7b98124b185ddd3</cites><orcidid>0000-0002-2328-6959</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.28989$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.28989$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32761812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muallem Kalmovich, Limor</creatorcontrib><creatorcontrib>Jabarin, Basel</creatorcontrib><creatorcontrib>Koren, Shlomit</creatorcontrib><creatorcontrib>Or, Karen</creatorcontrib><creatorcontrib>Marcus, Efrat</creatorcontrib><creatorcontrib>Tkacheva, Inna</creatorcontrib><creatorcontrib>Benbassat, Carlos</creatorcontrib><creatorcontrib>Steinschneider, Miriam</creatorcontrib><title>Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow‐up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with ≥2 (n = 34) versus ≥3 (n = 13) first‐relative affected members. Results There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the ≥3‐member group were 25% and 8.3% compared to 0% and 0% in the two‐member group (P = .02 and P = ns, respectively). Also, LN involvement was significantly higher in the ≥3‐member group (61.6% vs. 24.2%, respectively; P = .036). Conclusion FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the ≥3‐affected‐relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked. Level of Evidence 3/5 Laryngoscope, 131:E677–E681, 2021</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>familial non‐medullary thyroid cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Laryngoscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>prognosis</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>survival</subject><subject>Thyroid cancer</subject><subject>Thyroid Cancer, Papillary - diagnosis</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAcR4Mobk4vfgAJeBGhM2maJjlJGU4HU1Em6Cm0TTo72mUmVum3N7XTgwdPOfwfj18eAMcYjTFC4UWV2nYccsHFDhhiSnAQCUF3wdAfScBp-DwAB86tEMKMULQPBiRkMeY4HIKHmYPTtC6rMq3gnVnXWjVVJ4SL19aaUsFJus61hQm8NVbDZLm02rnyQ8NFu9HQFH_Ay0OwV6SV00fbdwSepleLyU0wv7-eTZJ5kBPKRMAyFCNSFGGeUUS1wpRhxAukeEaUTjmnAkUcRZryKC4wiTTLhJ8cZZhTpRQZgbPeu7HmrdHuXdaly7Ufv9amcTKMiP8iYxR79PQPujKNXft1nmIx50TEHXXeU7k1zlldyI0ta59CYiS70LLrIr9De_hkq2wy3-wX_SnrAdwDn2Wl239Ucp48vvTSL92Jhmg</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Muallem Kalmovich, Limor</creator><creator>Jabarin, Basel</creator><creator>Koren, Shlomit</creator><creator>Or, Karen</creator><creator>Marcus, Efrat</creator><creator>Tkacheva, Inna</creator><creator>Benbassat, Carlos</creator><creator>Steinschneider, Miriam</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2328-6959</orcidid></search><sort><creationdate>202102</creationdate><title>Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?</title><author>Muallem Kalmovich, Limor ; Jabarin, Basel ; Koren, Shlomit ; Or, Karen ; Marcus, Efrat ; Tkacheva, Inna ; Benbassat, Carlos ; Steinschneider, Miriam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-7b0603ff2cb505ed157108f0d8b3dea885904804e5846f134e7b98124b185ddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>familial non‐medullary thyroid cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Laryngoscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>prognosis</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>survival</topic><topic>Thyroid cancer</topic><topic>Thyroid Cancer, Papillary - diagnosis</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muallem Kalmovich, Limor</creatorcontrib><creatorcontrib>Jabarin, Basel</creatorcontrib><creatorcontrib>Koren, Shlomit</creatorcontrib><creatorcontrib>Or, Karen</creatorcontrib><creatorcontrib>Marcus, Efrat</creatorcontrib><creatorcontrib>Tkacheva, Inna</creatorcontrib><creatorcontrib>Benbassat, Carlos</creatorcontrib><creatorcontrib>Steinschneider, Miriam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muallem Kalmovich, Limor</au><au>Jabarin, Basel</au><au>Koren, Shlomit</au><au>Or, Karen</au><au>Marcus, Efrat</au><au>Tkacheva, Inna</au><au>Benbassat, Carlos</au><au>Steinschneider, Miriam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2021-02</date><risdate>2021</risdate><volume>131</volume><issue>2</issue><spage>E677</spage><epage>E681</epage><pages>E677-E681</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives Familial non‐medullary thyroid cancer (FNMTC) is a distinct entity, increasingly diagnosed. By lacking an accurate genetic diagnostic test, its diagnosis is currently clinically based, with an ongoing debate over whether it has a more aggressive clinical behavior than sporadic non‐medullary thyroid cancer (SNMTC). We seek to compare in this study, the clinicopathological variables, and the outcome of FNMTC versus SNMTC patients. Methods We retrospectively searched a database of 465 patients that underwent thyroidectomy at Assaf Harofeh Medical Center (91.4% between 1990 and 2019) for demographics, risk factors, medical history, diagnostic workup, primary treatment, follow‐up, and disease outcome data. We compared 47 FNMTC versus 321 SNMTC patients, and FNMTC patients with ≥2 (n = 34) versus ≥3 (n = 13) first‐relative affected members. Results There were no significant differences in demographics, histopathology, TNM stage, treatment, and disease outcome between the FNMTC and SNMTC groups. The T2 and T4 tumor stage in the ≥3‐member group were 25% and 8.3% compared to 0% and 0% in the two‐member group (P = .02 and P = ns, respectively). Also, LN involvement was significantly higher in the ≥3‐member group (61.6% vs. 24.2%, respectively; P = .036). Conclusion FNMTC is not a more aggressive disease than SNMTC, but this may not apply for the ≥3‐affected‐relatives group. A large multicenter study including only families with three or more affected relatives is needed. Until then, a family history of NMTC should not be overlooked. Level of Evidence 3/5 Laryngoscope, 131:E677–E681, 2021</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>32761812</pmid><doi>10.1002/lary.28989</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2328-6959</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0023-852X
ispartof The Laryngoscope, 2021-02, Vol.131 (2), p.E677-E681
issn 0023-852X
1531-4995
language eng
recordid cdi_proquest_miscellaneous_2431817751
source MEDLINE; Access via Wiley Online Library
subjects Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
familial non‐medullary thyroid cancer
Female
Humans
Laryngoscopy
Male
Middle Aged
prognosis
Retrospective Studies
Sex Factors
survival
Thyroid cancer
Thyroid Cancer, Papillary - diagnosis
Thyroid Cancer, Papillary - pathology
Thyroid Cancer, Papillary - surgery
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
Young Adult
title Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T01%3A16%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20Familial%20Nonmedullary%20Thyroid%20Cancer%20A%20More%20Aggressive%20Type%20of%20Thyroid%20Cancer?&rft.jtitle=The%20Laryngoscope&rft.au=Muallem%20Kalmovich,%20Limor&rft.date=2021-02&rft.volume=131&rft.issue=2&rft.spage=E677&rft.epage=E681&rft.pages=E677-E681&rft.issn=0023-852X&rft.eissn=1531-4995&rft_id=info:doi/10.1002/lary.28989&rft_dat=%3Cproquest_cross%3E2431817751%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2476883961&rft_id=info:pmid/32761812&rfr_iscdi=true