Effect of psychotropic drugs on cortical excitability of patients with major depressive disorders: A transcranial magnetic stimulation study

•Effect of psychotropic drugs on motor cortical excitability was evaluated with TMS in unmedicated patients with major depressive disorders.•Sertraline increased cortical excitability.•Quetiapine and olanzapine potentiated inhibitory GABAB neurotransmission.•TMS can differentiate between the impact...

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Veröffentlicht in:	Psychiatry research 2020-09, Vol.291, p.113287-113287, Article 113287
Hauptverfasser:	Khedr, Eman M, Elserogy, Yasser, Fawzy, Mohamed, Abdelrahman, Ahmed A., Galal, Amr M, Noaman, Mostafa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Beck depression inventory Cortical excitability Cortical Excitability - drug effects Cortical Excitability - physiology Cortical silent period Depressive Disorder, Major - drug therapy Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology DSM-V Evoked Potentials, Motor - drug effects Evoked Potentials, Motor - physiology Female GABA Glutamate Humans Major depressive disorder Male Motor Cortex - drug effects Motor Cortex - physiopathology Motor threshold Olanzapine Psychiatric Status Rating Scales Psychotropic drugs Quetiapine Sertraline Transcranial magnetic stimulation Transcranial Magnetic Stimulation - drug effects Transcranial Magnetic Stimulation - psychology Young Adult
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