Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats

Purpose Chronic intermittent hypoxia (IH) plays a pivotal role in the consequences of obstructive sleep apnea (OSA). It has been demonstrated that IH impairs nasomaxillary complex growth to reduce nasal airway cavity size in rodent models. Although turbinate dysfunction with inflammatory mucosal hyp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Sleep & breathing 2021-06, Vol.25 (2), p.677-684
Hauptverfasser:	Kuma, Yo-ichiro, Hosomichi, Jun, Maeda, Hideyuki, Oishi, Shuji, Usumi-Fujita, Risa, Shimizu, Yasuhiro, Kaneko, Sawa, Suzuki, Jun-ichi, Yoshida, Ken-ichi, Ono, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apnea Bone Carbon dioxide Collagen (type I) Dentistry E-cadherin Epithelial-Mesenchymal Transition - physiology Fibrosis Gene expression Humans Hypertrophy Hypertrophy - physiopathology Hypoxia Hypoxia - physiopathology IL-1β Inflammation Inflammation - physiopathology Interleukin 1 Internal Medicine Male Medicine Medicine & Public Health Mesenchyme Mucosa Mucous Membrane - physiopathology N-Cadherin Neurology Nose Otorhinolaryngology Pediatrics Pneumology/Respiratory System Rats Rats, Sprague-Dawley Rodents Sleep apnea Sleep Breathing Physiology and Disorders • Original Article Sleep disorders Transforming growth factor-b1 Tumor necrosis factor-α Turbinates - physiopathology Up-Regulation - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!