In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction

The transformation of electrical signals into mechanical action of the heart underlying blood circulation results in mechanical stimuli during active contraction or passive filling distention, which conversely modulate electrical signals. This feedback mechanism is known as cardiac mechano-electric...

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Veröffentlicht in:	Progress in biophysics and molecular biology 2021-01, Vol.159, p.22-33
Hauptverfasser:	Guo, Yang, Merten, Anna-Lena, Schöler, Ulrike, Yu, Ze-Yan, Cvetkovska, Jasmina, Fatkin, Diane, Feneley, Michael P., Martinac, Boris, Friedrich, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods Calcium - metabolism Cell Line Cell stretching device Cells, Cultured Dimethylpolysiloxanes - metabolism HL-1 Humans Ion Channels - metabolism Male Mechanosensitive ion channel Mechanotransduction Mechanotransduction, Cellular - physiology Mice Mice, Inbred C57BL Models, Biological Myocardium - cytology Myocardium - metabolism Myocytes, Cardiac - metabolism Piezo1 Polydimethylsiloxane (PDMS) Stress, Mechanical
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