Emerging cancer incidence trends in Canada: The growing burden of young adult cancers
Background Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012. Methods Canadian incidence data for 20 to 84 year‐olds were obtained from the Cancer...
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| Veröffentlicht in: | Cancer 2020-10, Vol.126 (20), p.4553-4562 |
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| creator | Heer, Emily V. Harper, Andrew S. Sung, Hyuna Jemal, Ahmedin Fidler‐Benaoudia, Miranda M. |
| description | Background
Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012.
Methods
Canadian incidence data for 20 to 84 year‐olds were obtained from the Cancer Incidence in Five Continents Plus database. Age‐period‐cohort modeling was used to estimate the average annual percentage changes (AAPCs) and incidence rate ratios (IRRs) for 10‐year birth cohorts (reference cohort, 1943) for 28 cancer types.
Results
Incidence increased for 13 cancer sites among adults younger than 50 years (1983‐2012), with the largest increase occurring for rectal cancer (AAPC20‐24, 5.62; 95% confidence interval [CI], 3.77‐7.51) and colon cancer (AAPC20‐24, 4.08; 95% CI, 2.89‐5.29). Compared with the 1943 birth cohort, persons born circa 1988 had approximately 5‐ and 2‐fold greater risks of rectal cancer (IRR, 4.98; 95% CI, 2.87‐8.63) and colon cancer (IRR, 2.31; 95% CI, 1.62‐3.30), respectively. Incidence decreased among younger adults for 9 sites (1983‐2012), with the largest decreases observed for lung cancer (AAPC25‐29,−2.29; 95% CI, −3.57 to −0.98), cervical cancer (AAPC25‐29, −1.29; 95% CI, −1.67 to −0.90), and melanoma (AAPC25‐29, −0.61; 95% CI, −0.97 to −0.24). Decreased risks in recent birth cohorts were observed for all sites with decreasing trends in younger adults. For example, the risk of lung cancer was 60% lower in the 1988 birth cohort than the 1943 birth cohort (IRR, 0.42; 95% CI, 0.23‐0.78).
Conclusions
Incidence among young adults is increasing for some cancers associated with obesity but decreasing for many cancers associated with infections or smoking. Although further studies are needed to replicate these findings and understand the etiology of early‐onset cancers, measures to promote healthy behaviors in young adults warranted.
Recent studies have documented concerning increases in cancer incidence among young adults. This study demonstrates further evidence of increasing trends in the incidence of some cancer sites among young adults in Canada, which may have implications for public health efforts. |
| doi_str_mv | 10.1002/cncr.33050 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2431807529</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2445944312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4590-d9824298173042ccd40ea397b22a0be13a726f162819b2037226470496bc79d33</originalsourceid><addsrcrecordid>eNp90M9LwzAUB_AgipvTi3-AFLyI0PnykjaNNynzB4iCbOCtpGk6O7p2Jitj_72ZnR48eEre48OXx5eQcwpjCoA3utF2zBhEcECGFKQIgXI8JEMASMKIs_cBOXFu4UeBETsmA4ZCgIhxSGaTpbHzqpkHWjXa2KBqdFUY_w3W1jSF84sgVY0q1G0w_TDB3LabHc8761nQlsG27fysiq5e70PcKTkqVe3M2f4dkdn9ZJo-hs-vD0_p3XOoeSQhLGSCHGVCBQOOWhccjGJS5IgKckOZEhiXNMaEyhyBCcSYC-AyzrWQBWMjctXnrmz72Rm3zpaV06auVWPazmXIGU1ARCg9vfxDF21nG3-dV_4a7il6dd0rbVvnrCmzla2Wym4zCtmu7GxXdvZdtscX-8guX5ril_606wHtwaaqzfafqCx9Sd_60C-zKYaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2445944312</pqid></control><display><type>article</type><title>Emerging cancer incidence trends in Canada: The growing burden of young adult cancers</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Heer, Emily V. ; Harper, Andrew S. ; Sung, Hyuna ; Jemal, Ahmedin ; Fidler‐Benaoudia, Miranda M.</creator><creatorcontrib>Heer, Emily V. ; Harper, Andrew S. ; Sung, Hyuna ; Jemal, Ahmedin ; Fidler‐Benaoudia, Miranda M.</creatorcontrib><description>Background
Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012.
Methods
Canadian incidence data for 20 to 84 year‐olds were obtained from the Cancer Incidence in Five Continents Plus database. Age‐period‐cohort modeling was used to estimate the average annual percentage changes (AAPCs) and incidence rate ratios (IRRs) for 10‐year birth cohorts (reference cohort, 1943) for 28 cancer types.
Results
Incidence increased for 13 cancer sites among adults younger than 50 years (1983‐2012), with the largest increase occurring for rectal cancer (AAPC20‐24, 5.62; 95% confidence interval [CI], 3.77‐7.51) and colon cancer (AAPC20‐24, 4.08; 95% CI, 2.89‐5.29). Compared with the 1943 birth cohort, persons born circa 1988 had approximately 5‐ and 2‐fold greater risks of rectal cancer (IRR, 4.98; 95% CI, 2.87‐8.63) and colon cancer (IRR, 2.31; 95% CI, 1.62‐3.30), respectively. Incidence decreased among younger adults for 9 sites (1983‐2012), with the largest decreases observed for lung cancer (AAPC25‐29,−2.29; 95% CI, −3.57 to −0.98), cervical cancer (AAPC25‐29, −1.29; 95% CI, −1.67 to −0.90), and melanoma (AAPC25‐29, −0.61; 95% CI, −0.97 to −0.24). Decreased risks in recent birth cohorts were observed for all sites with decreasing trends in younger adults. For example, the risk of lung cancer was 60% lower in the 1988 birth cohort than the 1943 birth cohort (IRR, 0.42; 95% CI, 0.23‐0.78).
Conclusions
Incidence among young adults is increasing for some cancers associated with obesity but decreasing for many cancers associated with infections or smoking. Although further studies are needed to replicate these findings and understand the etiology of early‐onset cancers, measures to promote healthy behaviors in young adults warranted.
Recent studies have documented concerning increases in cancer incidence among young adults. This study demonstrates further evidence of increasing trends in the incidence of some cancer sites among young adults in Canada, which may have implications for public health efforts.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.33050</identifier><identifier>PMID: 32770762</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adults ; Canada ; cancer prevention ; Cervical cancer ; Cervix ; Colon ; Colon cancer ; Colorectal cancer ; Confidence intervals ; epidemiology ; Etiology ; Health risks ; incidence ; Lung cancer ; Melanoma ; Oncology ; Rectum ; Trends ; young adult cancer ; Young adults</subject><ispartof>Cancer, 2020-10, Vol.126 (20), p.4553-4562</ispartof><rights>2020 American Cancer Society</rights><rights>2020 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4590-d9824298173042ccd40ea397b22a0be13a726f162819b2037226470496bc79d33</citedby><cites>FETCH-LOGICAL-c4590-d9824298173042ccd40ea397b22a0be13a726f162819b2037226470496bc79d33</cites><orcidid>0000-0002-0000-4111 ; 0000-0002-8021-5997 ; 0000-0001-9594-9881</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.33050$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.33050$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32770762$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heer, Emily V.</creatorcontrib><creatorcontrib>Harper, Andrew S.</creatorcontrib><creatorcontrib>Sung, Hyuna</creatorcontrib><creatorcontrib>Jemal, Ahmedin</creatorcontrib><creatorcontrib>Fidler‐Benaoudia, Miranda M.</creatorcontrib><title>Emerging cancer incidence trends in Canada: The growing burden of young adult cancers</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012.
Methods
Canadian incidence data for 20 to 84 year‐olds were obtained from the Cancer Incidence in Five Continents Plus database. Age‐period‐cohort modeling was used to estimate the average annual percentage changes (AAPCs) and incidence rate ratios (IRRs) for 10‐year birth cohorts (reference cohort, 1943) for 28 cancer types.
Results
Incidence increased for 13 cancer sites among adults younger than 50 years (1983‐2012), with the largest increase occurring for rectal cancer (AAPC20‐24, 5.62; 95% confidence interval [CI], 3.77‐7.51) and colon cancer (AAPC20‐24, 4.08; 95% CI, 2.89‐5.29). Compared with the 1943 birth cohort, persons born circa 1988 had approximately 5‐ and 2‐fold greater risks of rectal cancer (IRR, 4.98; 95% CI, 2.87‐8.63) and colon cancer (IRR, 2.31; 95% CI, 1.62‐3.30), respectively. Incidence decreased among younger adults for 9 sites (1983‐2012), with the largest decreases observed for lung cancer (AAPC25‐29,−2.29; 95% CI, −3.57 to −0.98), cervical cancer (AAPC25‐29, −1.29; 95% CI, −1.67 to −0.90), and melanoma (AAPC25‐29, −0.61; 95% CI, −0.97 to −0.24). Decreased risks in recent birth cohorts were observed for all sites with decreasing trends in younger adults. For example, the risk of lung cancer was 60% lower in the 1988 birth cohort than the 1943 birth cohort (IRR, 0.42; 95% CI, 0.23‐0.78).
Conclusions
Incidence among young adults is increasing for some cancers associated with obesity but decreasing for many cancers associated with infections or smoking. Although further studies are needed to replicate these findings and understand the etiology of early‐onset cancers, measures to promote healthy behaviors in young adults warranted.
Recent studies have documented concerning increases in cancer incidence among young adults. This study demonstrates further evidence of increasing trends in the incidence of some cancer sites among young adults in Canada, which may have implications for public health efforts.</description><subject>Adults</subject><subject>Canada</subject><subject>cancer prevention</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Confidence intervals</subject><subject>epidemiology</subject><subject>Etiology</subject><subject>Health risks</subject><subject>incidence</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Oncology</subject><subject>Rectum</subject><subject>Trends</subject><subject>young adult cancer</subject><subject>Young adults</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90M9LwzAUB_AgipvTi3-AFLyI0PnykjaNNynzB4iCbOCtpGk6O7p2Jitj_72ZnR48eEre48OXx5eQcwpjCoA3utF2zBhEcECGFKQIgXI8JEMASMKIs_cBOXFu4UeBETsmA4ZCgIhxSGaTpbHzqpkHWjXa2KBqdFUY_w3W1jSF84sgVY0q1G0w_TDB3LabHc8761nQlsG27fysiq5e70PcKTkqVe3M2f4dkdn9ZJo-hs-vD0_p3XOoeSQhLGSCHGVCBQOOWhccjGJS5IgKckOZEhiXNMaEyhyBCcSYC-AyzrWQBWMjctXnrmz72Rm3zpaV06auVWPazmXIGU1ARCg9vfxDF21nG3-dV_4a7il6dd0rbVvnrCmzla2Wym4zCtmu7GxXdvZdtscX-8guX5ril_606wHtwaaqzfafqCx9Sd_60C-zKYaw</recordid><startdate>20201015</startdate><enddate>20201015</enddate><creator>Heer, Emily V.</creator><creator>Harper, Andrew S.</creator><creator>Sung, Hyuna</creator><creator>Jemal, Ahmedin</creator><creator>Fidler‐Benaoudia, Miranda M.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0000-4111</orcidid><orcidid>https://orcid.org/0000-0002-8021-5997</orcidid><orcidid>https://orcid.org/0000-0001-9594-9881</orcidid></search><sort><creationdate>20201015</creationdate><title>Emerging cancer incidence trends in Canada: The growing burden of young adult cancers</title><author>Heer, Emily V. ; Harper, Andrew S. ; Sung, Hyuna ; Jemal, Ahmedin ; Fidler‐Benaoudia, Miranda M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4590-d9824298173042ccd40ea397b22a0be13a726f162819b2037226470496bc79d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adults</topic><topic>Canada</topic><topic>cancer prevention</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Confidence intervals</topic><topic>epidemiology</topic><topic>Etiology</topic><topic>Health risks</topic><topic>incidence</topic><topic>Lung cancer</topic><topic>Melanoma</topic><topic>Oncology</topic><topic>Rectum</topic><topic>Trends</topic><topic>young adult cancer</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heer, Emily V.</creatorcontrib><creatorcontrib>Harper, Andrew S.</creatorcontrib><creatorcontrib>Sung, Hyuna</creatorcontrib><creatorcontrib>Jemal, Ahmedin</creatorcontrib><creatorcontrib>Fidler‐Benaoudia, Miranda M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heer, Emily V.</au><au>Harper, Andrew S.</au><au>Sung, Hyuna</au><au>Jemal, Ahmedin</au><au>Fidler‐Benaoudia, Miranda M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging cancer incidence trends in Canada: The growing burden of young adult cancers</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2020-10-15</date><risdate>2020</risdate><volume>126</volume><issue>20</issue><spage>4553</spage><epage>4562</epage><pages>4553-4562</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012.
Methods
Canadian incidence data for 20 to 84 year‐olds were obtained from the Cancer Incidence in Five Continents Plus database. Age‐period‐cohort modeling was used to estimate the average annual percentage changes (AAPCs) and incidence rate ratios (IRRs) for 10‐year birth cohorts (reference cohort, 1943) for 28 cancer types.
Results
Incidence increased for 13 cancer sites among adults younger than 50 years (1983‐2012), with the largest increase occurring for rectal cancer (AAPC20‐24, 5.62; 95% confidence interval [CI], 3.77‐7.51) and colon cancer (AAPC20‐24, 4.08; 95% CI, 2.89‐5.29). Compared with the 1943 birth cohort, persons born circa 1988 had approximately 5‐ and 2‐fold greater risks of rectal cancer (IRR, 4.98; 95% CI, 2.87‐8.63) and colon cancer (IRR, 2.31; 95% CI, 1.62‐3.30), respectively. Incidence decreased among younger adults for 9 sites (1983‐2012), with the largest decreases observed for lung cancer (AAPC25‐29,−2.29; 95% CI, −3.57 to −0.98), cervical cancer (AAPC25‐29, −1.29; 95% CI, −1.67 to −0.90), and melanoma (AAPC25‐29, −0.61; 95% CI, −0.97 to −0.24). Decreased risks in recent birth cohorts were observed for all sites with decreasing trends in younger adults. For example, the risk of lung cancer was 60% lower in the 1988 birth cohort than the 1943 birth cohort (IRR, 0.42; 95% CI, 0.23‐0.78).
Conclusions
Incidence among young adults is increasing for some cancers associated with obesity but decreasing for many cancers associated with infections or smoking. Although further studies are needed to replicate these findings and understand the etiology of early‐onset cancers, measures to promote healthy behaviors in young adults warranted.
Recent studies have documented concerning increases in cancer incidence among young adults. This study demonstrates further evidence of increasing trends in the incidence of some cancer sites among young adults in Canada, which may have implications for public health efforts.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32770762</pmid><doi>10.1002/cncr.33050</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0000-4111</orcidid><orcidid>https://orcid.org/0000-0002-8021-5997</orcidid><orcidid>https://orcid.org/0000-0001-9594-9881</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Canada cancer prevention Cervical cancer Cervix Colon Colon cancer Colorectal cancer Confidence intervals epidemiology Etiology Health risks incidence Lung cancer Melanoma Oncology Rectum Trends young adult cancer Young adults |
| title | Emerging cancer incidence trends in Canada: The growing burden of young adult cancers |
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