Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model
Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E‐cadherin, known adhesion molecules, was variable or...
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| Veröffentlicht in: | Journal of dermatology 2020-11, Vol.47 (11), p.1330-1334 |
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| container_title | Journal of dermatology |
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| creator | Abe, Yuko Hozumi, Yutaka Okamura, Ken Suzuki, Tamio |
| description | Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E‐cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol‐induced leukoderma (RDIL) mice during the depigmentation process. Our findings suggest that melanocyte damage by rhododendrol promotes reduction of adhesion molecules not only in melanocytes but also in keratinocytes, and this is associated with the detachment of melanocytes from the basal layer. |
| doi_str_mv | 10.1111/1346-8138.15534 |
| format | Article |
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The mechanism of melanocyte loss is not yet known. In this report, we showed that the expression of discoidin domain receptor 1 and E‐cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol‐induced leukoderma (RDIL) mice during the depigmentation process. Our findings suggest that melanocyte damage by rhododendrol promotes reduction of adhesion molecules not only in melanocytes but also in keratinocytes, and this is associated with the detachment of melanocytes from the basal layer.</description><subject>Animals</subject><subject>Butanols</subject><subject>Cadherins</subject><subject>Dermatology</subject><subject>Discoidin Domain Receptor 1</subject><subject>Epidermis</subject><subject>E‐cadherin</subject><subject>Keratinocytes</subject><subject>Leukoderma</subject><subject>Melanin</subject><subject>Melanocytes</subject><subject>melanocytorrhagy</subject><subject>Mice</subject><subject>rhododendrol‐induced leukoderma</subject><subject>Rodents</subject><subject>Vitiligo</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb1OHDEURi2UKCwkNV1kKQ3NgP9mbMoINpAIKU1SW17fO1qTmfHE3gG2yyOkyBPyJHhYQpEmlmXL9vHRvfoIOeLshJdxyqVqKsOlOeF1LdUeWbzcvCILJk1dCcX0PjnI-YYxcVZz9obsS6E1M02zIH-W92PCnEMcaGwphOxjgDBQiL0rW0KP4yYmyqkbgC4ffv32DtaYyluZOAbA1IdMXdui32TaY-eG6LcbpCtcu9tQ_s6edYQIOECKXXGEASaPQDucfsTZ4Ggfp4xlBezektet6zK-e94PyfdPy2_nV9X118vP5x-vK68arqqmZR4MU3IlhK-R6ZUzCqBhWvq6nJkTpnGiNV6j5JIzBOehQeTCGc68PCTHO--Y4s8J88aWTjx2pQMs1VihJDdMC31W0A__oDdxSkOprlC1NpxrxQp1uqN8ijknbO2YQu_S1nJm58DsHI-d47FPgZUf75-906pHeOH_JlSAegfchQ63__PZLxfLnfgRbkujwA</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Abe, Yuko</creator><creator>Hozumi, Yutaka</creator><creator>Okamura, Ken</creator><creator>Suzuki, Tamio</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4669-9721</orcidid><orcidid>https://orcid.org/0000-0002-0903-873X</orcidid><orcidid>https://orcid.org/0000-0001-7366-3233</orcidid></search><sort><creationdate>202011</creationdate><title>Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model</title><author>Abe, Yuko ; Hozumi, Yutaka ; Okamura, Ken ; Suzuki, Tamio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4614-6f0cd8043b22c5e07ba84dd6073c55e00a286a2f8c7e31310edacd6ee12a810c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Butanols</topic><topic>Cadherins</topic><topic>Dermatology</topic><topic>Discoidin Domain Receptor 1</topic><topic>Epidermis</topic><topic>E‐cadherin</topic><topic>Keratinocytes</topic><topic>Leukoderma</topic><topic>Melanin</topic><topic>Melanocytes</topic><topic>melanocytorrhagy</topic><topic>Mice</topic><topic>rhododendrol‐induced leukoderma</topic><topic>Rodents</topic><topic>Vitiligo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abe, Yuko</creatorcontrib><creatorcontrib>Hozumi, Yutaka</creatorcontrib><creatorcontrib>Okamura, Ken</creatorcontrib><creatorcontrib>Suzuki, Tamio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abe, Yuko</au><au>Hozumi, Yutaka</au><au>Okamura, Ken</au><au>Suzuki, Tamio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>47</volume><issue>11</issue><spage>1330</spage><epage>1334</epage><pages>1330-1334</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Vitiligo is a depigmentation disease characterized by gradual loss of melanin and melanocytes from the epidermis. 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| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 2020-11, Vol.47 (11), p.1330-1334 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Animals Butanols Cadherins Dermatology Discoidin Domain Receptor 1 Epidermis E‐cadherin Keratinocytes Leukoderma Melanin Melanocytes melanocytorrhagy Mice rhododendrol‐induced leukoderma Rodents Vitiligo |
| title | Expression of discoidin domain receptor 1 and E‐cadherin in epidermis affects melanocyte behavior in rhododendrol‐induced leukoderma mouse model |
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