Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study
Background Limited research has been published on the recurrence of Helicobacter pylori infection and risk factors in Chinese children. Our study aimed to identify risk factors for Helicobacter pylori infection recurrence after successful eradication in children. Materials and Methods A prospective,...
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| Veröffentlicht in: | Helicobacter (Cambridge, Mass.) Mass.), 2020-10, Vol.25 (5), p.e12749-n/a |
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| creator | Zhang, Yuanda Dong, Qingwei Tian, Lei Zhang, Shaohui Zuo, Naying Zhang, Sisi Ding, Zhaolu |
| description | Background
Limited research has been published on the recurrence of Helicobacter pylori infection and risk factors in Chinese children. Our study aimed to identify risk factors for Helicobacter pylori infection recurrence after successful eradication in children.
Materials and Methods
A prospective, nested case‐control study was performed. A cohort of 230 children with successful eradication of Helicobacter pylori in Baoding (China) was selected from January 2018 to February 2019. A standardized questionnaire was used to obtain socioeconomic details. Eradication regimens and Helicobacter pylori antibiotic susceptibility testing results were also recorded. Interleukin‐1β level, interferon‐γ level, and genetic susceptibility (IFNGR1 and PTPRZ1 gene polymorphisms) were analyzed. All children were followed for 1 year.
Results
Among 218 (94.8%) children who were successfully followed, 41 children (18.8%) had a Helicobacter pylori infection recurrence. The recurrence rate was higher in children ≤10 years old than >10 years old (22.8% vs 7.1%, P = .01). There was no significant difference between the recurrence group and the non‐recurrence group in terms of types of therapy and antibiotic sensitivity (P > .05). Multivariable regression results indicated that residence in urban areas, higher household income, and having lunch at home were significantly protective against recurrence (OR 0.155, 0.408, and 0.351 respectively), whereas Helicobacter pylori infection in family members increased the risk of recurrence (OR 2.283). The levels of IL‐1β and IFN‐γ exhibited no significant difference between the recurrence group and the non‐recurrence group. The allele frequency of G in the IFNGR1‐56 site, A in the IFNGR1‐600 site, and T in the IFNGR1‐565 site was significantly higher in the recurrence group when compared to the non‐recurrence group (P |
| doi_str_mv | 10.1111/hel.12749 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2431807006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2431807006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3349-431108ca3ca270fcf84e5fa85de89bc8a9d16fba7c9a77731faabb0d8eb782c93</originalsourceid><addsrcrecordid>eNp1kcFuEzEURS0EoqWw4AeQJTZUIq099sQedlVUSKVISAjWI8-bZ8XFGQd7BpRdP6Hb_h5fwkvTskDCG1t-x9f36jL2WoozSet8jfFMVkY3T9ixrCs1q5WxT-ksrJppZZsj9qKUayFErXTznB2pyhgx1_qY3X0J5Tv3DsaUC_cp84ww5YwDIE-eLzEGSB3NMfPtLqYceBg8whjSwJ3fX5cJAEvxU-SYXR_A3Q_DwBfrMGBBDusQe9L8wC_4Nqey3b__ie85TUfsObiCv29uIQ1jTpGXcep3L9kz72LBVw_7Cfv28fLrYjlbff50tbhYzUBRGIonKSY4Ba4ywoO3GmvvbN2jbTqwrunl3HfOQOOMMUp657pO9BY7Yyto1Al7d9AlYz8m8tNuQgGM0Q2YptJW9IMVRog5oW__Qa_TlAdyR5TWc2mV0ESdHiigpCWjb7c5bFzetVK0-75a6qu974vYNw-KU7fB_i_5WBAB5wfgV4i4-79Su7xcHST_AB5Ao4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2444618304</pqid></control><display><type>article</type><title>Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhang, Yuanda ; Dong, Qingwei ; Tian, Lei ; Zhang, Shaohui ; Zuo, Naying ; Zhang, Sisi ; Ding, Zhaolu</creator><creatorcontrib>Zhang, Yuanda ; Dong, Qingwei ; Tian, Lei ; Zhang, Shaohui ; Zuo, Naying ; Zhang, Sisi ; Ding, Zhaolu</creatorcontrib><description>Background
Limited research has been published on the recurrence of Helicobacter pylori infection and risk factors in Chinese children. Our study aimed to identify risk factors for Helicobacter pylori infection recurrence after successful eradication in children.
Materials and Methods
A prospective, nested case‐control study was performed. A cohort of 230 children with successful eradication of Helicobacter pylori in Baoding (China) was selected from January 2018 to February 2019. A standardized questionnaire was used to obtain socioeconomic details. Eradication regimens and Helicobacter pylori antibiotic susceptibility testing results were also recorded. Interleukin‐1β level, interferon‐γ level, and genetic susceptibility (IFNGR1 and PTPRZ1 gene polymorphisms) were analyzed. All children were followed for 1 year.
Results
Among 218 (94.8%) children who were successfully followed, 41 children (18.8%) had a Helicobacter pylori infection recurrence. The recurrence rate was higher in children ≤10 years old than >10 years old (22.8% vs 7.1%, P = .01). There was no significant difference between the recurrence group and the non‐recurrence group in terms of types of therapy and antibiotic sensitivity (P > .05). Multivariable regression results indicated that residence in urban areas, higher household income, and having lunch at home were significantly protective against recurrence (OR 0.155, 0.408, and 0.351 respectively), whereas Helicobacter pylori infection in family members increased the risk of recurrence (OR 2.283). The levels of IL‐1β and IFN‐γ exhibited no significant difference between the recurrence group and the non‐recurrence group. The allele frequency of G in the IFNGR1‐56 site, A in the IFNGR1‐600 site, and T in the IFNGR1‐565 site was significantly higher in the recurrence group when compared to the non‐recurrence group (P < .05).
Conclusions
The Helicobacter pylori infection recurrence rate is high in children in Baoding region and is closely correlated to socioeconomic factors. The IFNGR1 gene polymorphism may be an independent risk factor for Helicobacter pylori infection recurrence.</description><identifier>ISSN: 1083-4389</identifier><identifier>EISSN: 1523-5378</identifier><identifier>DOI: 10.1111/hel.12749</identifier><identifier>PMID: 32770644</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Antibiotics ; Case-Control Studies ; Child ; Children ; China - epidemiology ; Eradication ; Female ; Gene frequency ; Gene polymorphism ; Genetic Predisposition to Disease ; H. pylori ; Health risks ; Helicobacter Infections - drug therapy ; Helicobacter Infections - epidemiology ; Helicobacter Infections - genetics ; Helicobacter pylori ; Humans ; Infections ; Interferon ; Interferon gamma Receptor ; Interleukins ; Male ; Polymorphism ; Polymorphism, Genetic ; Prospective Studies ; Receptors, Interferon - genetics ; Recurrence ; Regression analysis ; Risk analysis ; Risk Factors ; Social factors ; Socioeconomic data ; Socioeconomic Factors ; Socioeconomics ; Urban areas</subject><ispartof>Helicobacter (Cambridge, Mass.), 2020-10, Vol.25 (5), p.e12749-n/a</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3349-431108ca3ca270fcf84e5fa85de89bc8a9d16fba7c9a77731faabb0d8eb782c93</citedby><cites>FETCH-LOGICAL-c3349-431108ca3ca270fcf84e5fa85de89bc8a9d16fba7c9a77731faabb0d8eb782c93</cites><orcidid>0000-0001-5637-2960</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhel.12749$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhel.12749$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32770644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yuanda</creatorcontrib><creatorcontrib>Dong, Qingwei</creatorcontrib><creatorcontrib>Tian, Lei</creatorcontrib><creatorcontrib>Zhang, Shaohui</creatorcontrib><creatorcontrib>Zuo, Naying</creatorcontrib><creatorcontrib>Zhang, Sisi</creatorcontrib><creatorcontrib>Ding, Zhaolu</creatorcontrib><title>Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study</title><title>Helicobacter (Cambridge, Mass.)</title><addtitle>Helicobacter</addtitle><description>Background
Limited research has been published on the recurrence of Helicobacter pylori infection and risk factors in Chinese children. Our study aimed to identify risk factors for Helicobacter pylori infection recurrence after successful eradication in children.
Materials and Methods
A prospective, nested case‐control study was performed. A cohort of 230 children with successful eradication of Helicobacter pylori in Baoding (China) was selected from January 2018 to February 2019. A standardized questionnaire was used to obtain socioeconomic details. Eradication regimens and Helicobacter pylori antibiotic susceptibility testing results were also recorded. Interleukin‐1β level, interferon‐γ level, and genetic susceptibility (IFNGR1 and PTPRZ1 gene polymorphisms) were analyzed. All children were followed for 1 year.
Results
Among 218 (94.8%) children who were successfully followed, 41 children (18.8%) had a Helicobacter pylori infection recurrence. The recurrence rate was higher in children ≤10 years old than >10 years old (22.8% vs 7.1%, P = .01). There was no significant difference between the recurrence group and the non‐recurrence group in terms of types of therapy and antibiotic sensitivity (P > .05). Multivariable regression results indicated that residence in urban areas, higher household income, and having lunch at home were significantly protective against recurrence (OR 0.155, 0.408, and 0.351 respectively), whereas Helicobacter pylori infection in family members increased the risk of recurrence (OR 2.283). The levels of IL‐1β and IFN‐γ exhibited no significant difference between the recurrence group and the non‐recurrence group. The allele frequency of G in the IFNGR1‐56 site, A in the IFNGR1‐600 site, and T in the IFNGR1‐565 site was significantly higher in the recurrence group when compared to the non‐recurrence group (P < .05).
Conclusions
The Helicobacter pylori infection recurrence rate is high in children in Baoding region and is closely correlated to socioeconomic factors. The IFNGR1 gene polymorphism may be an independent risk factor for Helicobacter pylori infection recurrence.</description><subject>Antibiotics</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>China - epidemiology</subject><subject>Eradication</subject><subject>Female</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>H. pylori</subject><subject>Health risks</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - epidemiology</subject><subject>Helicobacter Infections - genetics</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon gamma Receptor</subject><subject>Interleukins</subject><subject>Male</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Prospective Studies</subject><subject>Receptors, Interferon - genetics</subject><subject>Recurrence</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Social factors</subject><subject>Socioeconomic data</subject><subject>Socioeconomic Factors</subject><subject>Socioeconomics</subject><subject>Urban areas</subject><issn>1083-4389</issn><issn>1523-5378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFuEzEURS0EoqWw4AeQJTZUIq099sQedlVUSKVISAjWI8-bZ8XFGQd7BpRdP6Hb_h5fwkvTskDCG1t-x9f36jL2WoozSet8jfFMVkY3T9ixrCs1q5WxT-ksrJppZZsj9qKUayFErXTznB2pyhgx1_qY3X0J5Tv3DsaUC_cp84ww5YwDIE-eLzEGSB3NMfPtLqYceBg8whjSwJ3fX5cJAEvxU-SYXR_A3Q_DwBfrMGBBDusQe9L8wC_4Nqey3b__ie85TUfsObiCv29uIQ1jTpGXcep3L9kz72LBVw_7Cfv28fLrYjlbff50tbhYzUBRGIonKSY4Ba4ywoO3GmvvbN2jbTqwrunl3HfOQOOMMUp657pO9BY7Yyto1Al7d9AlYz8m8tNuQgGM0Q2YptJW9IMVRog5oW__Qa_TlAdyR5TWc2mV0ESdHiigpCWjb7c5bFzetVK0-75a6qu974vYNw-KU7fB_i_5WBAB5wfgV4i4-79Su7xcHST_AB5Ao4g</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Zhang, Yuanda</creator><creator>Dong, Qingwei</creator><creator>Tian, Lei</creator><creator>Zhang, Shaohui</creator><creator>Zuo, Naying</creator><creator>Zhang, Sisi</creator><creator>Ding, Zhaolu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5637-2960</orcidid></search><sort><creationdate>202010</creationdate><title>Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study</title><author>Zhang, Yuanda ; Dong, Qingwei ; Tian, Lei ; Zhang, Shaohui ; Zuo, Naying ; Zhang, Sisi ; Ding, Zhaolu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3349-431108ca3ca270fcf84e5fa85de89bc8a9d16fba7c9a77731faabb0d8eb782c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotics</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children</topic><topic>China - epidemiology</topic><topic>Eradication</topic><topic>Female</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>H. pylori</topic><topic>Health risks</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - epidemiology</topic><topic>Helicobacter Infections - genetics</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interferon gamma Receptor</topic><topic>Interleukins</topic><topic>Male</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Prospective Studies</topic><topic>Receptors, Interferon - genetics</topic><topic>Recurrence</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Social factors</topic><topic>Socioeconomic data</topic><topic>Socioeconomic Factors</topic><topic>Socioeconomics</topic><topic>Urban areas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yuanda</creatorcontrib><creatorcontrib>Dong, Qingwei</creatorcontrib><creatorcontrib>Tian, Lei</creatorcontrib><creatorcontrib>Zhang, Shaohui</creatorcontrib><creatorcontrib>Zuo, Naying</creatorcontrib><creatorcontrib>Zhang, Sisi</creatorcontrib><creatorcontrib>Ding, Zhaolu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Helicobacter (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yuanda</au><au>Dong, Qingwei</au><au>Tian, Lei</au><au>Zhang, Shaohui</au><au>Zuo, Naying</au><au>Zhang, Sisi</au><au>Ding, Zhaolu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study</atitle><jtitle>Helicobacter (Cambridge, Mass.)</jtitle><addtitle>Helicobacter</addtitle><date>2020-10</date><risdate>2020</risdate><volume>25</volume><issue>5</issue><spage>e12749</spage><epage>n/a</epage><pages>e12749-n/a</pages><issn>1083-4389</issn><eissn>1523-5378</eissn><abstract>Background
Limited research has been published on the recurrence of Helicobacter pylori infection and risk factors in Chinese children. Our study aimed to identify risk factors for Helicobacter pylori infection recurrence after successful eradication in children.
Materials and Methods
A prospective, nested case‐control study was performed. A cohort of 230 children with successful eradication of Helicobacter pylori in Baoding (China) was selected from January 2018 to February 2019. A standardized questionnaire was used to obtain socioeconomic details. Eradication regimens and Helicobacter pylori antibiotic susceptibility testing results were also recorded. Interleukin‐1β level, interferon‐γ level, and genetic susceptibility (IFNGR1 and PTPRZ1 gene polymorphisms) were analyzed. All children were followed for 1 year.
Results
Among 218 (94.8%) children who were successfully followed, 41 children (18.8%) had a Helicobacter pylori infection recurrence. The recurrence rate was higher in children ≤10 years old than >10 years old (22.8% vs 7.1%, P = .01). There was no significant difference between the recurrence group and the non‐recurrence group in terms of types of therapy and antibiotic sensitivity (P > .05). Multivariable regression results indicated that residence in urban areas, higher household income, and having lunch at home were significantly protective against recurrence (OR 0.155, 0.408, and 0.351 respectively), whereas Helicobacter pylori infection in family members increased the risk of recurrence (OR 2.283). The levels of IL‐1β and IFN‐γ exhibited no significant difference between the recurrence group and the non‐recurrence group. The allele frequency of G in the IFNGR1‐56 site, A in the IFNGR1‐600 site, and T in the IFNGR1‐565 site was significantly higher in the recurrence group when compared to the non‐recurrence group (P < .05).
Conclusions
The Helicobacter pylori infection recurrence rate is high in children in Baoding region and is closely correlated to socioeconomic factors. The IFNGR1 gene polymorphism may be an independent risk factor for Helicobacter pylori infection recurrence.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32770644</pmid><doi>10.1111/hel.12749</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5637-2960</orcidid></addata></record> |
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| subjects | Antibiotics Case-Control Studies Child Children China - epidemiology Eradication Female Gene frequency Gene polymorphism Genetic Predisposition to Disease H. pylori Health risks Helicobacter Infections - drug therapy Helicobacter Infections - epidemiology Helicobacter Infections - genetics Helicobacter pylori Humans Infections Interferon Interferon gamma Receptor Interleukins Male Polymorphism Polymorphism, Genetic Prospective Studies Receptors, Interferon - genetics Recurrence Regression analysis Risk analysis Risk Factors Social factors Socioeconomic data Socioeconomic Factors Socioeconomics Urban areas |
| title | Risk factors for recurrence of Helicobacter pylori infection after successful eradication in Chinese children: A prospective, nested case‐control study |
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