Metformin Lowers Body Weight But Fails to Increase Insulin Sensitivity in Chronic Heart Failure Patients without Diabetes: a Randomized, Double-Blind, Placebo-Controlled Study

Purpose The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated wit...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2021-06, Vol.35 (3), p.491-503
Hauptverfasser:	Larsen, Anders Hostrup, Wiggers, Henrik, Dollerup, Ole Lindgård, Jespersen, Nichlas Riise, Hansson, Nils Henrik, Frøkiær, Jørgen, Brøsen, Kim, Nørrelund, Helene, Bøtker, Hans Erik, Møller, Niels, Jessen, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antidiabetics Bioelectricity Body Composition Body weight Body Weight - drug effects Calorimetry Calorimetry, Indirect Cardiology Clinical trials Congestive heart failure Diabetes Diabetes mellitus Double-Blind Method Double-blind studies Ejection fraction Energy expenditure Female Glucagon Glucagon - drug effects Glucose Glycated Hemoglobin A - drug effects Heart failure Heart Failure - drug therapy Heart Failure - physiopathology Hemoglobin Humans Insulin Insulin Resistance - physiology Lipids Male Medicine Medicine & Public Health Metabolism Metformin Metformin - pharmacology Middle Aged Mitochondria Mitochondria - drug effects Muscle, Skeletal - drug effects Muscles Musculoskeletal system Original Article Oxidation Oxygen consumption Oxygen Consumption - drug effects Palmitic acid Patients Placebos Respirometry Skeletal muscle Stroke Volume - drug effects Substrates Urea Ureas Weight reduction
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