Aromatase inhibitors combined with growth hormone in treatment of adolescent boys with short stature
To assess the efficacy and safety of aromatase inhibitors (AIs) combined growth hormone in treatment of adolescent boys with short stature. One hundred and fifty-one short stature pubertal boys with age of 10-14 years and bone age of 13-15 years, who were admitted to the Department of Pediatrics, th...
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| Veröffentlicht in: | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2020-05, Vol.49 (3), p.283-290 |
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| container_title | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
| container_volume | 49 |
| creator | Kong, Yuanmei Chen, Hong Liang, Li Zheng, Maoni Fang, Yanlan Wang, Chunlin |
| description | To assess the efficacy and safety of aromatase inhibitors (AIs) combined growth hormone in treatment of adolescent boys with short stature.
One hundred and fifty-one short stature pubertal boys with age of 10-14 years and bone age of 13-15 years, who were admitted to the Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, were included in this trial. According to their own or parents' intention, the children were divided into recombinant human growth hormone (rhGH)+AI group (
=108) and rhGH group (
=43). All children were injected subcutaneously with rhGH 0.15-0.2 IU·kg
·d
, and those in rhGH+AI group were additionally given 2.5 mg/d letrozole or 1 mg/d anastrozole, orally for 12 months or longer. The children were followed-up every 3 months. During the follow-up visit, the predicted adult height (PAH), sex hormone level, glucose and lipid metabolism, and other indicators were measured, and adverse reactions were monitored.
After intervention, there were significan |
| doi_str_mv | 10.3785/j.issn.1008-9292.2020.04.12 |
| format | Article |
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One hundred and fifty-one short stature pubertal boys with age of 10-14 years and bone age of 13-15 years, who were admitted to the Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, were included in this trial. According to their own or parents' intention, the children were divided into recombinant human growth hormone (rhGH)+AI group (
=108) and rhGH group (
=43). All children were injected subcutaneously with rhGH 0.15-0.2 IU·kg
·d
, and those in rhGH+AI group were additionally given 2.5 mg/d letrozole or 1 mg/d anastrozole, orally for 12 months or longer. The children were followed-up every 3 months. During the follow-up visit, the predicted adult height (PAH), sex hormone level, glucose and lipid metabolism, and other indicators were measured, and adverse reactions were monitored.
After intervention, there were significan</description><identifier>ISSN: 1008-9292</identifier><identifier>DOI: 10.3785/j.issn.1008-9292.2020.04.12</identifier><identifier>PMID: 32762170</identifier><language>chi</language><publisher>China</publisher><subject>Adolescent ; Aromatase Inhibitors - therapeutic use ; Body Height ; Child ; Growth Disorders ; Human Growth Hormone ; Humans ; Male ; Recombinant Proteins</subject><ispartof>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2020-05, Vol.49 (3), p.283-290</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32762170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Yuanmei</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Liang, Li</creatorcontrib><creatorcontrib>Zheng, Maoni</creatorcontrib><creatorcontrib>Fang, Yanlan</creatorcontrib><creatorcontrib>Wang, Chunlin</creatorcontrib><title>Aromatase inhibitors combined with growth hormone in treatment of adolescent boys with short stature</title><title>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</title><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><description>To assess the efficacy and safety of aromatase inhibitors (AIs) combined growth hormone in treatment of adolescent boys with short stature.
One hundred and fifty-one short stature pubertal boys with age of 10-14 years and bone age of 13-15 years, who were admitted to the Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, were included in this trial. According to their own or parents' intention, the children were divided into recombinant human growth hormone (rhGH)+AI group (
=108) and rhGH group (
=43). All children were injected subcutaneously with rhGH 0.15-0.2 IU·kg
·d
, and those in rhGH+AI group were additionally given 2.5 mg/d letrozole or 1 mg/d anastrozole, orally for 12 months or longer. The children were followed-up every 3 months. During the follow-up visit, the predicted adult height (PAH), sex hormone level, glucose and lipid metabolism, and other indicators were measured, and adverse reactions were monitored.
After intervention, there were significan</description><subject>Adolescent</subject><subject>Aromatase Inhibitors - therapeutic use</subject><subject>Body Height</subject><subject>Child</subject><subject>Growth Disorders</subject><subject>Human Growth Hormone</subject><subject>Humans</subject><subject>Male</subject><subject>Recombinant Proteins</subject><issn>1008-9292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1qwzAQhHVoaUKaVyiCXnqxu5JiyTqG0D8I9NKejWTJjYplpZJMyNvXIWnZw7DLt8MwCN0TKJmoq8fv0qU0lASgLiSVtKRAoYRVSegVmv-fZ2iZktNQESamgRs0Y1RwSgTMkVnH4FVWyWI37Jx2OcSE2-C1G6zBB5d3-CuGwyS7EH0YThzO0ars7ZBx6LAyobepPW06HNP5J010ximrPEZ7i6471Se7vOgCfT4_fWxei-37y9tmvS32hPJcSC07CUoQEEbw1pqaawbSdswIWVkhYKVZWxNlKwUt55pro8F0UplaVa1iC_Rw9t3H8DPalBvvpmB9rwYbxtTQFSM1cEL4hN5d0FF7a5p9dF7FY_PXDPsF8yJqMQ</recordid><startdate>20200525</startdate><enddate>20200525</enddate><creator>Kong, Yuanmei</creator><creator>Chen, Hong</creator><creator>Liang, Li</creator><creator>Zheng, Maoni</creator><creator>Fang, Yanlan</creator><creator>Wang, Chunlin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20200525</creationdate><title>Aromatase inhibitors combined with growth hormone in treatment of adolescent boys with short stature</title><author>Kong, Yuanmei ; Chen, Hong ; Liang, Li ; Zheng, Maoni ; Fang, Yanlan ; Wang, Chunlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-9b9f90a7107d76ced86b309ef3d795e7704b3c81ae5a0c66b6bdb0df9ad8a5ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Aromatase Inhibitors - therapeutic use</topic><topic>Body Height</topic><topic>Child</topic><topic>Growth Disorders</topic><topic>Human Growth Hormone</topic><topic>Humans</topic><topic>Male</topic><topic>Recombinant Proteins</topic><toplevel>online_resources</toplevel><creatorcontrib>Kong, Yuanmei</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Liang, Li</creatorcontrib><creatorcontrib>Zheng, Maoni</creatorcontrib><creatorcontrib>Fang, Yanlan</creatorcontrib><creatorcontrib>Wang, Chunlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Yuanmei</au><au>Chen, Hong</au><au>Liang, Li</au><au>Zheng, Maoni</au><au>Fang, Yanlan</au><au>Wang, Chunlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aromatase inhibitors combined with growth hormone in treatment of adolescent boys with short stature</atitle><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><date>2020-05-25</date><risdate>2020</risdate><volume>49</volume><issue>3</issue><spage>283</spage><epage>290</epage><pages>283-290</pages><issn>1008-9292</issn><abstract>To assess the efficacy and safety of aromatase inhibitors (AIs) combined growth hormone in treatment of adolescent boys with short stature.
One hundred and fifty-one short stature pubertal boys with age of 10-14 years and bone age of 13-15 years, who were admitted to the Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, were included in this trial. According to their own or parents' intention, the children were divided into recombinant human growth hormone (rhGH)+AI group (
=108) and rhGH group (
=43). All children were injected subcutaneously with rhGH 0.15-0.2 IU·kg
·d
, and those in rhGH+AI group were additionally given 2.5 mg/d letrozole or 1 mg/d anastrozole, orally for 12 months or longer. The children were followed-up every 3 months. During the follow-up visit, the predicted adult height (PAH), sex hormone level, glucose and lipid metabolism, and other indicators were measured, and adverse reactions were monitored.
After intervention, there were significan</abstract><cop>China</cop><pmid>32762170</pmid><doi>10.3785/j.issn.1008-9292.2020.04.12</doi><tpages>8</tpages></addata></record> |
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| ispartof | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2020-05, Vol.49 (3), p.283-290 |
| issn | 1008-9292 |
| language | chi |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Aromatase Inhibitors - therapeutic use Body Height Child Growth Disorders Human Growth Hormone Humans Male Recombinant Proteins |
| title | Aromatase inhibitors combined with growth hormone in treatment of adolescent boys with short stature |
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