Feasibility and rationale of direct current cardioversion immediately after transcatheter percutaneous edge‐to‐edge mitral valve repair
Aims Atrial fibrillation (AF) is a frequent comorbidity among patients with severe mitral regurgitation (MR). Direct current (DC) cardioversion is one of the strategies for rhythm control. However, the safety and feasibility of immediate DC cardioversion after MitraClip are not elucidated. Methods a...
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| Veröffentlicht in: | European journal of clinical investigation 2020-10, Vol.50 (10), p.e13274-n/a, Article 13274 |
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| creator | Lee, Ching‐Wei Frerker, Christian Huang, Wei‐Ming Tsai, Yi‐Lin Huang, Chi‐Jung Yu, Wen‐Chung Hsu, Chiao‐Po Chiang, Chern‐En Chen, Chen‐Huan Sung, Shih‐Hsien |
| description | Aims
Atrial fibrillation (AF) is a frequent comorbidity among patients with severe mitral regurgitation (MR). Direct current (DC) cardioversion is one of the strategies for rhythm control. However, the safety and feasibility of immediate DC cardioversion after MitraClip are not elucidated.
Methods and Results
In this study, patients with symptomatic severe MR who underwent MitraClip were included. After fixing the MR, synchronized DC cardioversion was attempted for those with AF. A total of consecutive 60 patients, 36 subjects (60%), comorbid with AF. DC cardioversion was performed in 30 patients (mean age of 76.0 ± 9.3 years), and the successful conversion was achieved in 15 patients (50%). There was no any adverse event related to the cardioversion. Subjects with sustained conversion to SR experienced significant improvement in 6MWT (failed: 285 ± 110‐308 ± 135 m, P = .278; successful: 269 ± 109 m‐328 ± 78, P = .047) and reduction in NT‐proBNP level (failed: 4411 ± 7401‐3296 ± 4299 ng/mL, P = .217; successful: 4094 ± 2735‐2353 ± 2856 ng/mL, P = .026) at 1 month.
Conclusions
Direct current cardioversion seemed to be safe and feasible immediately after the transcatheter edge‐to‐edge mitral valve repairs. Subjects who maintain SR experienced better functional improvement. |
| doi_str_mv | 10.1111/eci.13274 |
| format | Article |
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Atrial fibrillation (AF) is a frequent comorbidity among patients with severe mitral regurgitation (MR). Direct current (DC) cardioversion is one of the strategies for rhythm control. However, the safety and feasibility of immediate DC cardioversion after MitraClip are not elucidated.
Methods and Results
In this study, patients with symptomatic severe MR who underwent MitraClip were included. After fixing the MR, synchronized DC cardioversion was attempted for those with AF. A total of consecutive 60 patients, 36 subjects (60%), comorbid with AF. DC cardioversion was performed in 30 patients (mean age of 76.0 ± 9.3 years), and the successful conversion was achieved in 15 patients (50%). There was no any adverse event related to the cardioversion. Subjects with sustained conversion to SR experienced significant improvement in 6MWT (failed: 285 ± 110‐308 ± 135 m, P = .278; successful: 269 ± 109 m‐328 ± 78, P = .047) and reduction in NT‐proBNP level (failed: 4411 ± 7401‐3296 ± 4299 ng/mL, P = .217; successful: 4094 ± 2735‐2353 ± 2856 ng/mL, P = .026) at 1 month.
Conclusions
Direct current cardioversion seemed to be safe and feasible immediately after the transcatheter edge‐to‐edge mitral valve repairs. Subjects who maintain SR experienced better functional improvement.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.13274</identifier><identifier>PMID: 32762079</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject><![CDATA[atrial fibrillation ; Cardioversion ; Comorbidity ; Conversion ; Direct current ; Feasibility ; Fibrillation ; General & Internal Medicine ; Heart valves ; Life Sciences & Biomedicine ; Medicine, General & Internal ; Medicine, Research & Experimental ; MitraClip ; mitral regurgitation ; Mitral valve ; Regurgitation ; Research & Experimental Medicine ; Science & Technology]]></subject><ispartof>European journal of clinical investigation, 2020-10, Vol.50 (10), p.e13274-n/a, Article 13274</ispartof><rights>2020 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>Copyright © 2020 Stichting European Society for Clinical Investigation Journal Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000556082100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3304-aa614a39987fbdb7aad8df45f0e680448f610328c44aa09645331fe092f431743</citedby><cites>FETCH-LOGICAL-c3304-aa614a39987fbdb7aad8df45f0e680448f610328c44aa09645331fe092f431743</cites><orcidid>0000-0001-9871-6514</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Feci.13274$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Feci.13274$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,28255,45581,45582</link.rule.ids></links><search><creatorcontrib>Lee, Ching‐Wei</creatorcontrib><creatorcontrib>Frerker, Christian</creatorcontrib><creatorcontrib>Huang, Wei‐Ming</creatorcontrib><creatorcontrib>Tsai, Yi‐Lin</creatorcontrib><creatorcontrib>Huang, Chi‐Jung</creatorcontrib><creatorcontrib>Yu, Wen‐Chung</creatorcontrib><creatorcontrib>Hsu, Chiao‐Po</creatorcontrib><creatorcontrib>Chiang, Chern‐En</creatorcontrib><creatorcontrib>Chen, Chen‐Huan</creatorcontrib><creatorcontrib>Sung, Shih‐Hsien</creatorcontrib><title>Feasibility and rationale of direct current cardioversion immediately after transcatheter percutaneous edge‐to‐edge mitral valve repair</title><title>European journal of clinical investigation</title><addtitle>EUR J CLIN INVEST</addtitle><description>Aims
Atrial fibrillation (AF) is a frequent comorbidity among patients with severe mitral regurgitation (MR). Direct current (DC) cardioversion is one of the strategies for rhythm control. However, the safety and feasibility of immediate DC cardioversion after MitraClip are not elucidated.
Methods and Results
In this study, patients with symptomatic severe MR who underwent MitraClip were included. After fixing the MR, synchronized DC cardioversion was attempted for those with AF. A total of consecutive 60 patients, 36 subjects (60%), comorbid with AF. DC cardioversion was performed in 30 patients (mean age of 76.0 ± 9.3 years), and the successful conversion was achieved in 15 patients (50%). There was no any adverse event related to the cardioversion. Subjects with sustained conversion to SR experienced significant improvement in 6MWT (failed: 285 ± 110‐308 ± 135 m, P = .278; successful: 269 ± 109 m‐328 ± 78, P = .047) and reduction in NT‐proBNP level (failed: 4411 ± 7401‐3296 ± 4299 ng/mL, P = .217; successful: 4094 ± 2735‐2353 ± 2856 ng/mL, P = .026) at 1 month.
Conclusions
Direct current cardioversion seemed to be safe and feasible immediately after the transcatheter edge‐to‐edge mitral valve repairs. Subjects who maintain SR experienced better functional improvement.</description><subject>atrial fibrillation</subject><subject>Cardioversion</subject><subject>Comorbidity</subject><subject>Conversion</subject><subject>Direct current</subject><subject>Feasibility</subject><subject>Fibrillation</subject><subject>General & Internal Medicine</subject><subject>Heart valves</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine, General & Internal</subject><subject>Medicine, Research & Experimental</subject><subject>MitraClip</subject><subject>mitral regurgitation</subject><subject>Mitral valve</subject><subject>Regurgitation</subject><subject>Research & Experimental Medicine</subject><subject>Science & Technology</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqN0c1qFTEUB_Agir1WF75BwI0i0-ZrMpmlDG0tFNzoejg3c6IpM5Nrkrnl7ty78Rn7JOZ2igtBMIt8wO8kh_wJec3ZGS_jHK0_41I06gnZcKnrSkgtnpINY1xVom3ECXmR0i1jzBT2nJwUqwVr2g35eYmQ_NaPPh8ozAONkH2YYUQaHB18RJupXWLEuawQBx_2GFMh1E8TDh4yjqXSZYw0R5iThfwNj6cdRrtkmDEsieLwFe9__MqhTMc9nXzRI93DuEcacQc-viTPHIwJXz2up-TL5cXn7mN18-nquvtwU1kpmaoANFcg29Y0bjtsG4DBDE7VjqE2TCnjNGdSGKsUAGu1qqXkDlkrnJK8UfKUvF3v3cXwfcGU-8kni-O49tqLwgyr60YW-uYvehuWWL7nqMpTRtS6LurdqmwMKUV0_S76CeKh56w_JtSXhPqHhIp9v9o73AaXrMfZ4h9fIqprzYzgZcd40eb_defzQ3hdWOZcSs8fS_2Ih3931F9012trvwEIyLTs</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Lee, Ching‐Wei</creator><creator>Frerker, Christian</creator><creator>Huang, Wei‐Ming</creator><creator>Tsai, Yi‐Lin</creator><creator>Huang, Chi‐Jung</creator><creator>Yu, Wen‐Chung</creator><creator>Hsu, Chiao‐Po</creator><creator>Chiang, Chern‐En</creator><creator>Chen, Chen‐Huan</creator><creator>Sung, Shih‐Hsien</creator><general>Wiley</general><general>Blackwell Publishing Ltd</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9871-6514</orcidid></search><sort><creationdate>202010</creationdate><title>Feasibility and rationale of direct current cardioversion immediately after transcatheter percutaneous edge‐to‐edge mitral valve repair</title><author>Lee, Ching‐Wei ; Frerker, Christian ; Huang, Wei‐Ming ; Tsai, Yi‐Lin ; Huang, Chi‐Jung ; Yu, Wen‐Chung ; Hsu, Chiao‐Po ; Chiang, Chern‐En ; Chen, Chen‐Huan ; Sung, Shih‐Hsien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3304-aa614a39987fbdb7aad8df45f0e680448f610328c44aa09645331fe092f431743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>atrial fibrillation</topic><topic>Cardioversion</topic><topic>Comorbidity</topic><topic>Conversion</topic><topic>Direct current</topic><topic>Feasibility</topic><topic>Fibrillation</topic><topic>General & Internal Medicine</topic><topic>Heart valves</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine, General & Internal</topic><topic>Medicine, Research & Experimental</topic><topic>MitraClip</topic><topic>mitral regurgitation</topic><topic>Mitral valve</topic><topic>Regurgitation</topic><topic>Research & Experimental Medicine</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ching‐Wei</creatorcontrib><creatorcontrib>Frerker, Christian</creatorcontrib><creatorcontrib>Huang, Wei‐Ming</creatorcontrib><creatorcontrib>Tsai, Yi‐Lin</creatorcontrib><creatorcontrib>Huang, Chi‐Jung</creatorcontrib><creatorcontrib>Yu, Wen‐Chung</creatorcontrib><creatorcontrib>Hsu, Chiao‐Po</creatorcontrib><creatorcontrib>Chiang, Chern‐En</creatorcontrib><creatorcontrib>Chen, Chen‐Huan</creatorcontrib><creatorcontrib>Sung, Shih‐Hsien</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ching‐Wei</au><au>Frerker, Christian</au><au>Huang, Wei‐Ming</au><au>Tsai, Yi‐Lin</au><au>Huang, Chi‐Jung</au><au>Yu, Wen‐Chung</au><au>Hsu, Chiao‐Po</au><au>Chiang, Chern‐En</au><au>Chen, Chen‐Huan</au><au>Sung, Shih‐Hsien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility and rationale of direct current cardioversion immediately after transcatheter percutaneous edge‐to‐edge mitral valve repair</atitle><jtitle>European journal of clinical investigation</jtitle><stitle>EUR J CLIN INVEST</stitle><date>2020-10</date><risdate>2020</risdate><volume>50</volume><issue>10</issue><spage>e13274</spage><epage>n/a</epage><pages>e13274-n/a</pages><artnum>13274</artnum><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Aims
Atrial fibrillation (AF) is a frequent comorbidity among patients with severe mitral regurgitation (MR). Direct current (DC) cardioversion is one of the strategies for rhythm control. However, the safety and feasibility of immediate DC cardioversion after MitraClip are not elucidated.
Methods and Results
In this study, patients with symptomatic severe MR who underwent MitraClip were included. After fixing the MR, synchronized DC cardioversion was attempted for those with AF. A total of consecutive 60 patients, 36 subjects (60%), comorbid with AF. DC cardioversion was performed in 30 patients (mean age of 76.0 ± 9.3 years), and the successful conversion was achieved in 15 patients (50%). There was no any adverse event related to the cardioversion. Subjects with sustained conversion to SR experienced significant improvement in 6MWT (failed: 285 ± 110‐308 ± 135 m, P = .278; successful: 269 ± 109 m‐328 ± 78, P = .047) and reduction in NT‐proBNP level (failed: 4411 ± 7401‐3296 ± 4299 ng/mL, P = .217; successful: 4094 ± 2735‐2353 ± 2856 ng/mL, P = .026) at 1 month.
Conclusions
Direct current cardioversion seemed to be safe and feasible immediately after the transcatheter edge‐to‐edge mitral valve repairs. Subjects who maintain SR experienced better functional improvement.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>32762079</pmid><doi>10.1111/eci.13274</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9871-6514</orcidid></addata></record> |
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| source | Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Wiley Online Library All Journals |
| subjects | atrial fibrillation Cardioversion Comorbidity Conversion Direct current Feasibility Fibrillation General & Internal Medicine Heart valves Life Sciences & Biomedicine Medicine, General & Internal Medicine, Research & Experimental MitraClip mitral regurgitation Mitral valve Regurgitation Research & Experimental Medicine Science & Technology |
| title | Feasibility and rationale of direct current cardioversion immediately after transcatheter percutaneous edge‐to‐edge mitral valve repair |
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