Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene
Objectives Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. Design We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to...
Gespeichert in:
| Veröffentlicht in: | Digestive diseases and sciences 2021-07, Vol.66 (7), p.2283-2290 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2290 |
|---|---|
| container_issue | 7 |
| container_start_page | 2283 |
| container_title | Digestive diseases and sciences |
| container_volume | 66 |
| creator | Talukdar, Rupjyoti Aslam, Mohsin Reddy, D. Nageshwar Nabi, Zaheer Shava, Upender Ravikanth, V. V. Avanthi, Steffie Govardhan, B. |
| description | Objectives
Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.
Design
We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Patients were divided into those with/without PD. Associations between the significantly prevalent SNPs and IRAP/ICP in the presence of PD were evaluated. Clinical data were analyzed using Mann–Whitney U/Chi-square test. Effect size of association of SNPs with IRAP/ICP was expressed as odds ratio (OR) (95% CI). Gene–gene interaction was assessed by transheterozygosity analyses. Bonferroni-corrected two-tailed “
p
” value of ≤ 0.01 was considered statistically significant.
Results
Thirty-three (19.8%) and 82 (29.7%) patients with IRAP and ICP, respectively, had PD. Among the patients with IRAP, duration of disease was significantly shorter in those with PD compared to those without (mean [95% CI] duration: 1.6 (1.3–1.9) vs 2.7 (2.3–3.1) years;
p
= 0.005). There were no differences in gender, race, and diabetes among patients with/without PD in IRAP/ICP groups. Mean (95% CI) pancreatic duct diameter (mm) was significantly higher in the presence of PD in patients with both IRAP [1.6 (1.4–1.9) v/s 1.29 (1.2–1.4);
p
= 0.03)] and ICP [5.2 (4.5–5.9) v/s 4.5 (3.9–5.1);
p
= 0.02]. CTSB
(rs12338)
polymorphisms were significantly associated with IRAP [OR (95% CI) 2.44 (1.41–4.22);
p
= 0.001] among patients with PD. No association was observed with ICP. Transheterozygosity analysis did not show any significant associations of combination of SNPs with IRAP in the presence of PD.
Conclusion
Risk of RAP due to PD increases in patients with rs12338 polymorphism in the cathepsin B gene. |
| doi_str_mv | 10.1007/s10620-020-06517-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2430671295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712933472</galeid><sourcerecordid>A712933472</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-ae8c9379821401f55ac65a38b998f87ae2d627fa4f6fe04e451779a02762bb3a3</originalsourceid><addsrcrecordid>eNp9kV1rFTEQhoMoeKz-Aa8C3nizNR-bZPfyeNRaKFiKXoecdNKTups9ZrKVXvrPzbIFPxAJk2Qyz_syZAh5ydkpZ8y8Qc60YA1bQituGvOIbLgyshFKd4_JhnFd75zrp-QZ4i1jrDdcb8iPS5d8Bof0XbyLOI_0fM0BaTkAvYr4lU6BXoGfc4ZU6NbPBeiDrMQSkcZU8xJrFen3WA40IxdSdvRyGu7HKR8PEceFWhx3ru5HrNlbegYJnpMnwQ0ILx7OE_Llw_vPu4_Nxaez8932ovEt70vjoPO9NH0neMt4UMp5rZzs9n3fhc44ENdamODaoAOwFtr6C6Z3TBgt9nvp5Al5vfoe8_RtBix2jOhhGFyCaUYrWsm04aJXFX31F3o7zTnV7qxQrRJdZX6jbtwANqYwlez8Ymq3i4-UrRGVOv0HVdc1jNFPCUKs738IxCrweULMEOwxx9Hle8uZXYZt12FbtsQybGuqSK4irHC6gfyr4_-ofgIU0aos</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2545289535</pqid></control><display><type>article</type><title>Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene</title><source>Springer Nature - Complete Springer Journals</source><creator>Talukdar, Rupjyoti ; Aslam, Mohsin ; Reddy, D. Nageshwar ; Nabi, Zaheer ; Shava, Upender ; Ravikanth, V. V. ; Avanthi, Steffie ; Govardhan, B.</creator><creatorcontrib>Talukdar, Rupjyoti ; Aslam, Mohsin ; Reddy, D. Nageshwar ; Nabi, Zaheer ; Shava, Upender ; Ravikanth, V. V. ; Avanthi, Steffie ; Govardhan, B.</creatorcontrib><description>Objectives
Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.
Design
We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Patients were divided into those with/without PD. Associations between the significantly prevalent SNPs and IRAP/ICP in the presence of PD were evaluated. Clinical data were analyzed using Mann–Whitney U/Chi-square test. Effect size of association of SNPs with IRAP/ICP was expressed as odds ratio (OR) (95% CI). Gene–gene interaction was assessed by transheterozygosity analyses. Bonferroni-corrected two-tailed “
p
” value of ≤ 0.01 was considered statistically significant.
Results
Thirty-three (19.8%) and 82 (29.7%) patients with IRAP and ICP, respectively, had PD. Among the patients with IRAP, duration of disease was significantly shorter in those with PD compared to those without (mean [95% CI] duration: 1.6 (1.3–1.9) vs 2.7 (2.3–3.1) years;
p
= 0.005). There were no differences in gender, race, and diabetes among patients with/without PD in IRAP/ICP groups. Mean (95% CI) pancreatic duct diameter (mm) was significantly higher in the presence of PD in patients with both IRAP [1.6 (1.4–1.9) v/s 1.29 (1.2–1.4);
p
= 0.03)] and ICP [5.2 (4.5–5.9) v/s 4.5 (3.9–5.1);
p
= 0.02]. CTSB
(rs12338)
polymorphisms were significantly associated with IRAP [OR (95% CI) 2.44 (1.41–4.22);
p
= 0.001] among patients with PD. No association was observed with ICP. Transheterozygosity analysis did not show any significant associations of combination of SNPs with IRAP in the presence of PD.
Conclusion
Risk of RAP due to PD increases in patients with rs12338 polymorphism in the cathepsin B gene.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-020-06517-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Care and treatment ; Cathepsins ; Diseases ; Gastroenterology ; Genes ; Genetic aspects ; Genetic polymorphisms ; Hepatology ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Pancreatitis ; Polymorphism ; Relapse ; Transplant Surgery</subject><ispartof>Digestive diseases and sciences, 2021-07, Vol.66 (7), p.2283-2290</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-ae8c9379821401f55ac65a38b998f87ae2d627fa4f6fe04e451779a02762bb3a3</citedby><cites>FETCH-LOGICAL-c419t-ae8c9379821401f55ac65a38b998f87ae2d627fa4f6fe04e451779a02762bb3a3</cites><orcidid>0000-0002-4255-6651</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-020-06517-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-020-06517-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Talukdar, Rupjyoti</creatorcontrib><creatorcontrib>Aslam, Mohsin</creatorcontrib><creatorcontrib>Reddy, D. Nageshwar</creatorcontrib><creatorcontrib>Nabi, Zaheer</creatorcontrib><creatorcontrib>Shava, Upender</creatorcontrib><creatorcontrib>Ravikanth, V. V.</creatorcontrib><creatorcontrib>Avanthi, Steffie</creatorcontrib><creatorcontrib>Govardhan, B.</creatorcontrib><title>Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Objectives
Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.
Design
We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Patients were divided into those with/without PD. Associations between the significantly prevalent SNPs and IRAP/ICP in the presence of PD were evaluated. Clinical data were analyzed using Mann–Whitney U/Chi-square test. Effect size of association of SNPs with IRAP/ICP was expressed as odds ratio (OR) (95% CI). Gene–gene interaction was assessed by transheterozygosity analyses. Bonferroni-corrected two-tailed “
p
” value of ≤ 0.01 was considered statistically significant.
Results
Thirty-three (19.8%) and 82 (29.7%) patients with IRAP and ICP, respectively, had PD. Among the patients with IRAP, duration of disease was significantly shorter in those with PD compared to those without (mean [95% CI] duration: 1.6 (1.3–1.9) vs 2.7 (2.3–3.1) years;
p
= 0.005). There were no differences in gender, race, and diabetes among patients with/without PD in IRAP/ICP groups. Mean (95% CI) pancreatic duct diameter (mm) was significantly higher in the presence of PD in patients with both IRAP [1.6 (1.4–1.9) v/s 1.29 (1.2–1.4);
p
= 0.03)] and ICP [5.2 (4.5–5.9) v/s 4.5 (3.9–5.1);
p
= 0.02]. CTSB
(rs12338)
polymorphisms were significantly associated with IRAP [OR (95% CI) 2.44 (1.41–4.22);
p
= 0.001] among patients with PD. No association was observed with ICP. Transheterozygosity analysis did not show any significant associations of combination of SNPs with IRAP in the presence of PD.
Conclusion
Risk of RAP due to PD increases in patients with rs12338 polymorphism in the cathepsin B gene.</description><subject>Biochemistry</subject><subject>Care and treatment</subject><subject>Cathepsins</subject><subject>Diseases</subject><subject>Gastroenterology</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Hepatology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pancreatitis</subject><subject>Polymorphism</subject><subject>Relapse</subject><subject>Transplant Surgery</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kV1rFTEQhoMoeKz-Aa8C3nizNR-bZPfyeNRaKFiKXoecdNKTups9ZrKVXvrPzbIFPxAJk2Qyz_syZAh5ydkpZ8y8Qc60YA1bQituGvOIbLgyshFKd4_JhnFd75zrp-QZ4i1jrDdcb8iPS5d8Bof0XbyLOI_0fM0BaTkAvYr4lU6BXoGfc4ZU6NbPBeiDrMQSkcZU8xJrFen3WA40IxdSdvRyGu7HKR8PEceFWhx3ru5HrNlbegYJnpMnwQ0ILx7OE_Llw_vPu4_Nxaez8932ovEt70vjoPO9NH0neMt4UMp5rZzs9n3fhc44ENdamODaoAOwFtr6C6Z3TBgt9nvp5Al5vfoe8_RtBix2jOhhGFyCaUYrWsm04aJXFX31F3o7zTnV7qxQrRJdZX6jbtwANqYwlez8Ymq3i4-UrRGVOv0HVdc1jNFPCUKs738IxCrweULMEOwxx9Hle8uZXYZt12FbtsQybGuqSK4irHC6gfyr4_-ofgIU0aos</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Talukdar, Rupjyoti</creator><creator>Aslam, Mohsin</creator><creator>Reddy, D. Nageshwar</creator><creator>Nabi, Zaheer</creator><creator>Shava, Upender</creator><creator>Ravikanth, V. V.</creator><creator>Avanthi, Steffie</creator><creator>Govardhan, B.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4255-6651</orcidid></search><sort><creationdate>20210701</creationdate><title>Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene</title><author>Talukdar, Rupjyoti ; Aslam, Mohsin ; Reddy, D. Nageshwar ; Nabi, Zaheer ; Shava, Upender ; Ravikanth, V. V. ; Avanthi, Steffie ; Govardhan, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-ae8c9379821401f55ac65a38b998f87ae2d627fa4f6fe04e451779a02762bb3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biochemistry</topic><topic>Care and treatment</topic><topic>Cathepsins</topic><topic>Diseases</topic><topic>Gastroenterology</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Hepatology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pancreatitis</topic><topic>Polymorphism</topic><topic>Relapse</topic><topic>Transplant Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talukdar, Rupjyoti</creatorcontrib><creatorcontrib>Aslam, Mohsin</creatorcontrib><creatorcontrib>Reddy, D. Nageshwar</creatorcontrib><creatorcontrib>Nabi, Zaheer</creatorcontrib><creatorcontrib>Shava, Upender</creatorcontrib><creatorcontrib>Ravikanth, V. V.</creatorcontrib><creatorcontrib>Avanthi, Steffie</creatorcontrib><creatorcontrib>Govardhan, B.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talukdar, Rupjyoti</au><au>Aslam, Mohsin</au><au>Reddy, D. Nageshwar</au><au>Nabi, Zaheer</au><au>Shava, Upender</au><au>Ravikanth, V. V.</au><au>Avanthi, Steffie</au><au>Govardhan, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>66</volume><issue>7</issue><spage>2283</spage><epage>2290</epage><pages>2283-2290</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Objectives
Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD.
Design
We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Patients were divided into those with/without PD. Associations between the significantly prevalent SNPs and IRAP/ICP in the presence of PD were evaluated. Clinical data were analyzed using Mann–Whitney U/Chi-square test. Effect size of association of SNPs with IRAP/ICP was expressed as odds ratio (OR) (95% CI). Gene–gene interaction was assessed by transheterozygosity analyses. Bonferroni-corrected two-tailed “
p
” value of ≤ 0.01 was considered statistically significant.
Results
Thirty-three (19.8%) and 82 (29.7%) patients with IRAP and ICP, respectively, had PD. Among the patients with IRAP, duration of disease was significantly shorter in those with PD compared to those without (mean [95% CI] duration: 1.6 (1.3–1.9) vs 2.7 (2.3–3.1) years;
p
= 0.005). There were no differences in gender, race, and diabetes among patients with/without PD in IRAP/ICP groups. Mean (95% CI) pancreatic duct diameter (mm) was significantly higher in the presence of PD in patients with both IRAP [1.6 (1.4–1.9) v/s 1.29 (1.2–1.4);
p
= 0.03)] and ICP [5.2 (4.5–5.9) v/s 4.5 (3.9–5.1);
p
= 0.02]. CTSB
(rs12338)
polymorphisms were significantly associated with IRAP [OR (95% CI) 2.44 (1.41–4.22);
p
= 0.001] among patients with PD. No association was observed with ICP. Transheterozygosity analysis did not show any significant associations of combination of SNPs with IRAP in the presence of PD.
Conclusion
Risk of RAP due to PD increases in patients with rs12338 polymorphism in the cathepsin B gene.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10620-020-06517-7</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4255-6651</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2021-07, Vol.66 (7), p.2283-2290 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2430671295 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biochemistry Care and treatment Cathepsins Diseases Gastroenterology Genes Genetic aspects Genetic polymorphisms Hepatology Medicine Medicine & Public Health Oncology Original Article Pancreatitis Polymorphism Relapse Transplant Surgery |
| title | Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T02%3A47%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pancreas%20Divisum%20Increases%20the%20Risk%20of%20Recurrent%20Acute%20Pancreatitis%20in%20Patients%20with%20rs12338%20Polymorphism%20in%20the%20Cathepsin%20B%20Gene&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=Talukdar,%20Rupjyoti&rft.date=2021-07-01&rft.volume=66&rft.issue=7&rft.spage=2283&rft.epage=2290&rft.pages=2283-2290&rft.issn=0163-2116&rft.eissn=1573-2568&rft_id=info:doi/10.1007/s10620-020-06517-7&rft_dat=%3Cgale_proqu%3EA712933472%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2545289535&rft_id=info:pmid/&rft_galeid=A712933472&rfr_iscdi=true |