Black mulberry fruit extract alleviates streptozotocin-induced diabetic nephropathy in rats: targeting TNF-α inflammatory pathway

Abstract Objectives This study was designed to investigate the effect of Morus nigra fruit extract in retarding the progression of diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Methods Diabetic male Wistar rats were injected with black mulberry fruit extract (BMFE) at doses of...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2020-11, Vol.72 (11), p.1615-1628
Hauptverfasser:	Abouzed, Tarek Kamal, Sadek, Kadry M, Ghazy, Emad Waded, Abdo, Walied, Kassab, Mohmed Atef, Hago, Salma, Abdel-Wahab, Samia, Mahrous, Engy A, Abdel-Sattar, Essam, Assar, Doaa H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Body weight Catalase Cell adhesion & migration Cell adhesion molecules Creatinine cyanidin glycosides Diabetes Diabetes mellitus Diabetic nephropathy Dietary supplements Fibronectin Fruits Gene expression Inflammation Insulin Kidneys Morus nigra Morus nigra fruit extract Nephropathy Oxidative stress Peroxide phenolic compounds proinflammatory cytokines Rodents Sclerosis Streptozocin Tumor necrosis factor
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