Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC‐25L in facial lower‐third aesthetic treatment: A prospective multicenter study

Background Dermal fillers have become an integral part of any aesthetic physician's intervention. Aims To assess, by means of ultrasounds, the tissue integration of the hyaluronic acid (HA) dermal filler VYC‐25L in chin and jaw. Methods Prospective, noncomparative, open‐label, and multicenter study conducted on healthy subjects, with age comprised between 30 and 60 years old, who attended to the clinic to perform a facial rejuvenation treatment of the lower third of the face. VYC‐25L was injected using a 27G needle (supraperiosteal bolus, from 0.2 to 0.3 mL per bolus) in the chin and with canula (retrograde threads, from 0.4 to 0.6 mL) in the jaw. Ultrasound examinations (UE) were performed at each study center by the same experienced observer at baseline, immediately after injection, 48 hours, and 30 days after treatment. Results Thirty patients (10 per center) were included in the study. At baseline, UE found a characteristic heterogeneous pattern of subcutaneous cellular tissue, with alternation of soft anechoic and hyperechoic images. The UE, performed immediately after treatment, showed a poorly defined globular ultrasound pattern, with anechoic images indicative of liquid content. Forty‐eight hours after treatment, UE are still showing a globular pattern, with well‐defined anechoic areas. Thirty days after treatment, a thickening of the subcutaneous cellular tissue was observed in all the evaluated zones, with a total integration of the HA into the tissue. Conclusion VYC‐25L might represent a significant advance in volumization/restoration of the lower face. Its biointegration was total at day 30 and practically complete at 48 hours of treatment.