High fitness might be associated with the development of new‐onset atrial fibrillation in obese non‐athletic adults
Background Data on the association between AF and fitness are conflicting. Objectives The aim of this analysis was to investigate the association between fitness, obesity and incidence of atrial fibrillation (AF) among apparently healthy non‐athlete adults. Methods We investigated 20 410 self‐referr...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2020-12, Vol.74 (12), p.e13638-n/a |
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| creator | Younis, Arwa Berkovitch, Anat Segev, Shlomo Kivity, Shaye Klempfner, Robert Abu‐Much, Arsalan Goldenberg, Ilan Maor, Elad |
| description | Background
Data on the association between AF and fitness are conflicting.
Objectives
The aim of this analysis was to investigate the association between fitness, obesity and incidence of atrial fibrillation (AF) among apparently healthy non‐athlete adults.
Methods
We investigated 20 410 self‐referred subjects who were annually screened in a tertiary medical centre. All subjects were free of AF and completed maximal exercise stress test according to the Bruce protocol at baseline. Fitness was categorised into age‐ and sex‐specific quintiles (Q) according to the treadmill time. Subjects were categorised to low (Q1‐Q2) and high fitness (Q3‐5) groups. The primary end point was new‐onset AF during follow‐up.
Results
Mean age was 48 ± 10 years and 72% were men. A total of 463 (2.3%) events occurred during an average follow‐up of 8 ± 5 years corresponding to an AF event rate of 0.3% per person year. Univariate and multivariate models showed that AF risk was similar in both fitness groups. However, AF event rate was 0.55% per person year among high fitness obese subjects, compared with 0.31% for low fitness obese subjects (P |
| doi_str_mv | 10.1111/ijcp.13638 |
| format | Article |
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Data on the association between AF and fitness are conflicting.
Objectives
The aim of this analysis was to investigate the association between fitness, obesity and incidence of atrial fibrillation (AF) among apparently healthy non‐athlete adults.
Methods
We investigated 20 410 self‐referred subjects who were annually screened in a tertiary medical centre. All subjects were free of AF and completed maximal exercise stress test according to the Bruce protocol at baseline. Fitness was categorised into age‐ and sex‐specific quintiles (Q) according to the treadmill time. Subjects were categorised to low (Q1‐Q2) and high fitness (Q3‐5) groups. The primary end point was new‐onset AF during follow‐up.
Results
Mean age was 48 ± 10 years and 72% were men. A total of 463 (2.3%) events occurred during an average follow‐up of 8 ± 5 years corresponding to an AF event rate of 0.3% per person year. Univariate and multivariate models showed that AF risk was similar in both fitness groups. However, AF event rate was 0.55% per person year among high fitness obese subjects, compared with 0.31% for low fitness obese subjects (P < .01). Subgroup interaction analysis showed that AF risk is obesity‐dependent, such that in the obese group (≥30 kg/m2) high fitness was independently associated with a significant 79% increased AF risk (95% CI 1.15‐2.78; P = .01), whereas among non‐obese subjects the rate of events was similar between both fitness groups (P for interaction = (.02)).
Conclusions
Our findings suggest that high fitness might be associated with increased AF risk among obese subjects.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.13638</identifier><identifier>PMID: 32750733</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Adult ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - etiology ; Cardiac arrhythmia ; Cardiac stress tests ; Exercise Test ; Female ; Fibrillation ; Humans ; Incidence ; Male ; Middle Aged ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Physical fitness ; Risk Factors</subject><ispartof>International journal of clinical practice (Esher), 2020-12, Vol.74 (12), p.e13638-n/a</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3938-72923d8262900bb9eb0aec68b850fb2ed5e012657453b8851051798908c3ff7b3</citedby><cites>FETCH-LOGICAL-c3938-72923d8262900bb9eb0aec68b850fb2ed5e012657453b8851051798908c3ff7b3</cites><orcidid>0000-0002-2485-5025</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.13638$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.13638$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32750733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Younis, Arwa</creatorcontrib><creatorcontrib>Berkovitch, Anat</creatorcontrib><creatorcontrib>Segev, Shlomo</creatorcontrib><creatorcontrib>Kivity, Shaye</creatorcontrib><creatorcontrib>Klempfner, Robert</creatorcontrib><creatorcontrib>Abu‐Much, Arsalan</creatorcontrib><creatorcontrib>Goldenberg, Ilan</creatorcontrib><creatorcontrib>Maor, Elad</creatorcontrib><title>High fitness might be associated with the development of new‐onset atrial fibrillation in obese non‐athletic adults</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Background
Data on the association between AF and fitness are conflicting.
Objectives
The aim of this analysis was to investigate the association between fitness, obesity and incidence of atrial fibrillation (AF) among apparently healthy non‐athlete adults.
Methods
We investigated 20 410 self‐referred subjects who were annually screened in a tertiary medical centre. All subjects were free of AF and completed maximal exercise stress test according to the Bruce protocol at baseline. Fitness was categorised into age‐ and sex‐specific quintiles (Q) according to the treadmill time. Subjects were categorised to low (Q1‐Q2) and high fitness (Q3‐5) groups. The primary end point was new‐onset AF during follow‐up.
Results
Mean age was 48 ± 10 years and 72% were men. A total of 463 (2.3%) events occurred during an average follow‐up of 8 ± 5 years corresponding to an AF event rate of 0.3% per person year. Univariate and multivariate models showed that AF risk was similar in both fitness groups. However, AF event rate was 0.55% per person year among high fitness obese subjects, compared with 0.31% for low fitness obese subjects (P < .01). Subgroup interaction analysis showed that AF risk is obesity‐dependent, such that in the obese group (≥30 kg/m2) high fitness was independently associated with a significant 79% increased AF risk (95% CI 1.15‐2.78; P = .01), whereas among non‐obese subjects the rate of events was similar between both fitness groups (P for interaction = (.02)).
Conclusions
Our findings suggest that high fitness might be associated with increased AF risk among obese subjects.</description><subject>Adult</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - etiology</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac stress tests</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Physical fitness</subject><subject>Risk Factors</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctKxDAUBuAgijNeNj6ABNyI0DGXpk2XMnhlQBe6Lkl76mRok7FJHdz5CD6jT2J01IULs0kCHz-H8yN0QMmExnNqFtVyQnnG5QYa0zxlCWUp3YxvnslEEE5HaMf7BSFMCEm20YizXJCc8zFaXZnHOW5MsOA97uInYA1Yee8qowLUeGXCHIc54BqeoXXLDmzArsEWVu-vb856CFiF3qg2xujetK0KxllsLHYaPGDrbIQqzFsIpsKqHtrg99BWo1oP-9_3Lnq4OL-fXiWz28vr6dksqXjBZZKzgvFasowVhGhdgCYKqkxqKUijGdQCCGWZyFPBtZSCEkHzQhZEVrxpcs130fE6d9m7pwF8KDvjK4hDWnCDL1nKSZYxlrNIj_7QhRt6G6eLKuOUCpamUZ2sVdU773toymVvOtW_lJSUn3WUn3WUX3VEfPgdOegO6l_6s_8I6BqsTAsv_0SV1zfTu3XoB54zlu4</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Younis, Arwa</creator><creator>Berkovitch, Anat</creator><creator>Segev, Shlomo</creator><creator>Kivity, Shaye</creator><creator>Klempfner, Robert</creator><creator>Abu‐Much, Arsalan</creator><creator>Goldenberg, Ilan</creator><creator>Maor, Elad</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2485-5025</orcidid></search><sort><creationdate>202012</creationdate><title>High fitness might be associated with the development of new‐onset atrial fibrillation in obese non‐athletic adults</title><author>Younis, Arwa ; Berkovitch, Anat ; Segev, Shlomo ; Kivity, Shaye ; Klempfner, Robert ; Abu‐Much, Arsalan ; Goldenberg, Ilan ; Maor, Elad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-72923d8262900bb9eb0aec68b850fb2ed5e012657453b8851051798908c3ff7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - etiology</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac stress tests</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Physical fitness</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Younis, Arwa</creatorcontrib><creatorcontrib>Berkovitch, Anat</creatorcontrib><creatorcontrib>Segev, Shlomo</creatorcontrib><creatorcontrib>Kivity, Shaye</creatorcontrib><creatorcontrib>Klempfner, Robert</creatorcontrib><creatorcontrib>Abu‐Much, Arsalan</creatorcontrib><creatorcontrib>Goldenberg, Ilan</creatorcontrib><creatorcontrib>Maor, Elad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Younis, Arwa</au><au>Berkovitch, Anat</au><au>Segev, Shlomo</au><au>Kivity, Shaye</au><au>Klempfner, Robert</au><au>Abu‐Much, Arsalan</au><au>Goldenberg, Ilan</au><au>Maor, Elad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High fitness might be associated with the development of new‐onset atrial fibrillation in obese non‐athletic adults</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2020-12</date><risdate>2020</risdate><volume>74</volume><issue>12</issue><spage>e13638</spage><epage>n/a</epage><pages>e13638-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background
Data on the association between AF and fitness are conflicting.
Objectives
The aim of this analysis was to investigate the association between fitness, obesity and incidence of atrial fibrillation (AF) among apparently healthy non‐athlete adults.
Methods
We investigated 20 410 self‐referred subjects who were annually screened in a tertiary medical centre. All subjects were free of AF and completed maximal exercise stress test according to the Bruce protocol at baseline. Fitness was categorised into age‐ and sex‐specific quintiles (Q) according to the treadmill time. Subjects were categorised to low (Q1‐Q2) and high fitness (Q3‐5) groups. The primary end point was new‐onset AF during follow‐up.
Results
Mean age was 48 ± 10 years and 72% were men. A total of 463 (2.3%) events occurred during an average follow‐up of 8 ± 5 years corresponding to an AF event rate of 0.3% per person year. Univariate and multivariate models showed that AF risk was similar in both fitness groups. However, AF event rate was 0.55% per person year among high fitness obese subjects, compared with 0.31% for low fitness obese subjects (P < .01). Subgroup interaction analysis showed that AF risk is obesity‐dependent, such that in the obese group (≥30 kg/m2) high fitness was independently associated with a significant 79% increased AF risk (95% CI 1.15‐2.78; P = .01), whereas among non‐obese subjects the rate of events was similar between both fitness groups (P for interaction = (.02)).
Conclusions
Our findings suggest that high fitness might be associated with increased AF risk among obese subjects.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>32750733</pmid><doi>10.1111/ijcp.13638</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2485-5025</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1368-5031 |
| ispartof | International journal of clinical practice (Esher), 2020-12, Vol.74 (12), p.e13638-n/a |
| issn | 1368-5031 1742-1241 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Atrial Fibrillation - epidemiology Atrial Fibrillation - etiology Cardiac arrhythmia Cardiac stress tests Exercise Test Female Fibrillation Humans Incidence Male Middle Aged Obesity Obesity - complications Obesity - epidemiology Physical fitness Risk Factors |
| title | High fitness might be associated with the development of new‐onset atrial fibrillation in obese non‐athletic adults |
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