Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs

G protein-coupled receptors (GPCRs) form a superfamily of plasma membrane receptors that couple to four major families of heterotrimeric G proteins, G s , G i , G q , and G 12 . GPCRs represent excellent targets for drug therapy. Since the individual GPCRs are expressed by many different cell types,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Annual review of pharmacology and toxicology 2021-01, Vol.61 (1), p.421-440
Hauptverfasser:	Wang, Lei, Zhu, Lu, Meister, Jaroslawna, Bone, Derek B.J, Pydi, Sai P, Rossi, Mario, Wess, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	DREADD technology G protein-coupled receptors G proteins mutant mouse models obesity type 2 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!