Improved Beta Cell Glucose Sensitivity Plays Predominant Role in the Decrease in HbA1c with Cana and Lira in T2DM

Abstract Aim To examine the effect of combination therapy with canagliflozin plus liraglutide versus each agent alone on beta cell function in type 2 diabetes mellitus (T2DM) patients. Research Design and Methods A total of 45 poorly controlled (HbA1c = 7%-11%) T2DM patients received an oral glucose...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-10, Vol.105 (10), p.3226-3233
Hauptverfasser:	Ali, Ali Muhammed, Mari, Andrea, Martinez, Robert, Al-Jobori, Hussein, Adams, John, Triplitt, Curtis, DeFronzo, Ralph, Cersosimo, Eugenio, Abdul-Ghani, Muhammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells Blood Glucose - analysis Blood Glucose - drug effects Blood Glucose - metabolism Canagliflozin - administration & dosage Development and progression Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - drug therapy Drug therapy Drug therapy, Combination Drug Therapy, Combination - methods Female Glucose Glucose tolerance Glucose Tolerance Test Glycated Hemoglobin A - analysis Health aspects Hemoglobin Humans Insulin Insulin secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Liraglutide Liraglutide - administration & dosage Male Methods Middle Aged Pancreatic beta cells Patient outcomes Secretion Treatment Outcome Type 2 diabetes
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