Frontline Science: Cxxc5 expression alters cell cycle and myeloid differentiation of mouse hematopoietic stem and progenitor cells

CXXC5 is a member of the CXXC‐type zinc finger epigenetic regulators. Various hematopoietic and nonhematopoietic roles have been assigned to CXXC5. In the present study, the role of Cxxc5 in myelopoiesis was studied using overexpression and short hairpin RNA‐mediated knockdown in mouse early stem an...

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Veröffentlicht in:	Journal of leukocyte biology 2020-08, Vol.108 (2), p.469-484
Hauptverfasser:	Joshi, Hemant R., Hill, Harry R., Zhou, Zemin, He, Xiao, Voelkerding, Karl V., Kumánovics, Attila
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Bone Marrow Cells - cytology Bone Marrow Cells - metabolism cell cycle Cell Cycle - genetics Cell Differentiation - genetics DNA-Binding Proteins - genetics epigenetic regulation Flow Cytometry Gene Expression Profiling Gene Expression Regulation, Developmental Gene Knockout Techniques Hematopoietic stem cell Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism High-Throughput Nucleotide Sequencing Mice Mice, Transgenic myeloid cell development Myeloid Cells - cytology Myeloid Cells - metabolism Myelopoiesis TET2 Transcription Factors - genetics
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