The physiological functions and pharmaceutical applications of inulin: A review
•Inulin, a fructan-type plant polysaccharide with average MW 5600−6300 g mol−1.•Inulin has functions of prebiotics, antioxidant, reglualting lipid metabolism, etc.•Inulin can be a carrier for colon/tumor-targeting drug delivery. Inulin (IN), a fructan-type plant polysaccharide, is widely found in na...
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| Veröffentlicht in: | Carbohydrate polymers 2020-10, Vol.246, p.116589-116589, Article 116589 |
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| creator | Wan, Xinhuan Guo, Hao Liang, Yiyu Zhou, Changzheng Liu, Zihao Li, Kunwei Niu, Fengju Zhai, Xin Wang, Lizhu |
| description | •Inulin, a fructan-type plant polysaccharide with average MW 5600−6300 g mol−1.•Inulin has functions of prebiotics, antioxidant, reglualting lipid metabolism, etc.•Inulin can be a carrier for colon/tumor-targeting drug delivery.
Inulin (IN), a fructan-type plant polysaccharide, is widely found in nature. The major plant sources of IN include chicory, Jerusalem artichoke, dahlia etc. Studies have found that IN possessed a wide array of biological activities, e.g. as a prebiotic to improve the intestinal microbe environment, regulating blood sugar, regulating blood lipids, antioxidant, anticancer, immune regulation and so on. Currently, IN is widely used in the food and pharmaceutical industries. IN can be used as thickener, fat replacer, sweetener and water retaining agent in the food industry. IN also can be applied in the pharmaceutics as stabilizer, drug carrier, and auxiliary therapeutic agent for certain diseases such as constipation and diabetes. This paper reviews the physiological functions of IN and its applications in the field of pharmaceutics, analyzes its present research status and future research direction. This review will serve as a one-in-all resource for the researchers who are interested to work on IN. |
| doi_str_mv | 10.1016/j.carbpol.2020.116589 |
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Inulin (IN), a fructan-type plant polysaccharide, is widely found in nature. The major plant sources of IN include chicory, Jerusalem artichoke, dahlia etc. Studies have found that IN possessed a wide array of biological activities, e.g. as a prebiotic to improve the intestinal microbe environment, regulating blood sugar, regulating blood lipids, antioxidant, anticancer, immune regulation and so on. Currently, IN is widely used in the food and pharmaceutical industries. IN can be used as thickener, fat replacer, sweetener and water retaining agent in the food industry. IN also can be applied in the pharmaceutics as stabilizer, drug carrier, and auxiliary therapeutic agent for certain diseases such as constipation and diabetes. This paper reviews the physiological functions of IN and its applications in the field of pharmaceutics, analyzes its present research status and future research direction. This review will serve as a one-in-all resource for the researchers who are interested to work on IN.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2020.116589</identifier><identifier>PMID: 32747248</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject><![CDATA[Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacology ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Blood Glucose - metabolism ; Cichorium intybus - chemistry ; Dahlia - chemistry ; Drug Carriers - chemistry ; Drug delivery ; Excipients - chemistry ; Excipients - isolation & purification ; Helianthus - chemistry ; Humans ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - isolation & purification ; Hypoglycemic Agents - metabolism ; Hypoglycemic Agents - pharmacology ; Immunologic Factors - chemistry ; Immunologic Factors - isolation & purification ; Immunologic Factors - metabolism ; Immunologic Factors - pharmacology ; Inulin ; Inulin - chemistry ; Inulin - isolation & purification ; Inulin - metabolism ; Inulin - pharmacology ; Laxatives - chemistry ; Laxatives - isolation & purification ; Laxatives - metabolism ; Laxatives - pharmacology ; Lipids - blood ; Pharmaceutical applications ; Physiological functions ; Prebiotics ; Prebiotics - administration & dosage ; Stabilizer ; Sweetening Agents - chemistry ; Sweetening Agents - isolation & purification]]></subject><ispartof>Carbohydrate polymers, 2020-10, Vol.246, p.116589-116589, Article 116589</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-a2f3dfe3bd359a4c8a2578a0176dcc9799283f747f5cc8d2380b61854605dd463</citedby><cites>FETCH-LOGICAL-c431t-a2f3dfe3bd359a4c8a2578a0176dcc9799283f747f5cc8d2380b61854605dd463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0144861720307633$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32747248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Xinhuan</creatorcontrib><creatorcontrib>Guo, Hao</creatorcontrib><creatorcontrib>Liang, Yiyu</creatorcontrib><creatorcontrib>Zhou, Changzheng</creatorcontrib><creatorcontrib>Liu, Zihao</creatorcontrib><creatorcontrib>Li, Kunwei</creatorcontrib><creatorcontrib>Niu, Fengju</creatorcontrib><creatorcontrib>Zhai, Xin</creatorcontrib><creatorcontrib>Wang, Lizhu</creatorcontrib><title>The physiological functions and pharmaceutical applications of inulin: A review</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•Inulin, a fructan-type plant polysaccharide with average MW 5600−6300 g mol−1.•Inulin has functions of prebiotics, antioxidant, reglualting lipid metabolism, etc.•Inulin can be a carrier for colon/tumor-targeting drug delivery.
Inulin (IN), a fructan-type plant polysaccharide, is widely found in nature. The major plant sources of IN include chicory, Jerusalem artichoke, dahlia etc. Studies have found that IN possessed a wide array of biological activities, e.g. as a prebiotic to improve the intestinal microbe environment, regulating blood sugar, regulating blood lipids, antioxidant, anticancer, immune regulation and so on. Currently, IN is widely used in the food and pharmaceutical industries. IN can be used as thickener, fat replacer, sweetener and water retaining agent in the food industry. IN also can be applied in the pharmaceutics as stabilizer, drug carrier, and auxiliary therapeutic agent for certain diseases such as constipation and diabetes. This paper reviews the physiological functions of IN and its applications in the field of pharmaceutics, analyzes its present research status and future research direction. This review will serve as a one-in-all resource for the researchers who are interested to work on IN.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Blood Glucose - metabolism</subject><subject>Cichorium intybus - chemistry</subject><subject>Dahlia - chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Drug delivery</subject><subject>Excipients - chemistry</subject><subject>Excipients - isolation & purification</subject><subject>Helianthus - chemistry</subject><subject>Humans</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - isolation & purification</subject><subject>Hypoglycemic Agents - metabolism</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Immunologic Factors - chemistry</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - metabolism</subject><subject>Immunologic Factors - pharmacology</subject><subject>Inulin</subject><subject>Inulin - chemistry</subject><subject>Inulin - isolation & purification</subject><subject>Inulin - metabolism</subject><subject>Inulin - pharmacology</subject><subject>Laxatives - chemistry</subject><subject>Laxatives - isolation & purification</subject><subject>Laxatives - metabolism</subject><subject>Laxatives - pharmacology</subject><subject>Lipids - blood</subject><subject>Pharmaceutical applications</subject><subject>Physiological functions</subject><subject>Prebiotics</subject><subject>Prebiotics - administration & dosage</subject><subject>Stabilizer</subject><subject>Sweetening Agents - chemistry</subject><subject>Sweetening Agents - isolation & purification</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaAs2aT4lcRhg6qKl1Spm7K2HNuhrpw42Amof49LClu8sTX3zlzPAeAawTmCKL_bzaXwVefsHEMcayjPWHkCpogVZYoIpadgChGlKctRMQEXIexgPDmC52BCcEELTNkUrDdbnXTbfTDOuncjhU3qoZW9cW1IRKuiJnwjpB76H1F0nY2PUXd1YtrBmvY-WSRefxr9dQnOamGDvjreM_D29LhZvqSr9fPrcrFKJSWoTwWuiao1qRTJSkElEzgrmICoyJWUZVGWmJE6frLOpGQKEwarHLGM5jBTiuZkBm7HuZ13H4MOPW9MkNpa0Wo3BI4pgaRAGMJozUar9C4Er2veedMIv-cI8gNLvuNHlvzAko8sY9_NMWKoGq3-un7hRcPDaNBx0bi850Ea3UqtjNey58qZfyK-Ac2th9Q</recordid><startdate>20201015</startdate><enddate>20201015</enddate><creator>Wan, Xinhuan</creator><creator>Guo, Hao</creator><creator>Liang, Yiyu</creator><creator>Zhou, Changzheng</creator><creator>Liu, Zihao</creator><creator>Li, Kunwei</creator><creator>Niu, Fengju</creator><creator>Zhai, Xin</creator><creator>Wang, Lizhu</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201015</creationdate><title>The physiological functions and pharmaceutical applications of inulin: A review</title><author>Wan, Xinhuan ; Guo, Hao ; Liang, Yiyu ; Zhou, Changzheng ; Liu, Zihao ; Li, Kunwei ; Niu, Fengju ; Zhai, Xin ; Wang, Lizhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-a2f3dfe3bd359a4c8a2578a0176dcc9799283f747f5cc8d2380b61854605dd463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Blood Glucose - metabolism</topic><topic>Cichorium intybus - chemistry</topic><topic>Dahlia - chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Drug delivery</topic><topic>Excipients - chemistry</topic><topic>Excipients - isolation & purification</topic><topic>Helianthus - chemistry</topic><topic>Humans</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - isolation & purification</topic><topic>Hypoglycemic Agents - metabolism</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Immunologic Factors - chemistry</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - metabolism</topic><topic>Immunologic Factors - pharmacology</topic><topic>Inulin</topic><topic>Inulin - chemistry</topic><topic>Inulin - isolation & purification</topic><topic>Inulin - metabolism</topic><topic>Inulin - pharmacology</topic><topic>Laxatives - chemistry</topic><topic>Laxatives - isolation & purification</topic><topic>Laxatives - metabolism</topic><topic>Laxatives - pharmacology</topic><topic>Lipids - blood</topic><topic>Pharmaceutical applications</topic><topic>Physiological functions</topic><topic>Prebiotics</topic><topic>Prebiotics - administration & dosage</topic><topic>Stabilizer</topic><topic>Sweetening Agents - chemistry</topic><topic>Sweetening Agents - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan, Xinhuan</creatorcontrib><creatorcontrib>Guo, Hao</creatorcontrib><creatorcontrib>Liang, Yiyu</creatorcontrib><creatorcontrib>Zhou, Changzheng</creatorcontrib><creatorcontrib>Liu, Zihao</creatorcontrib><creatorcontrib>Li, Kunwei</creatorcontrib><creatorcontrib>Niu, Fengju</creatorcontrib><creatorcontrib>Zhai, Xin</creatorcontrib><creatorcontrib>Wang, Lizhu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, Xinhuan</au><au>Guo, Hao</au><au>Liang, Yiyu</au><au>Zhou, Changzheng</au><au>Liu, Zihao</au><au>Li, Kunwei</au><au>Niu, Fengju</au><au>Zhai, Xin</au><au>Wang, Lizhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The physiological functions and pharmaceutical applications of inulin: A review</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2020-10-15</date><risdate>2020</risdate><volume>246</volume><spage>116589</spage><epage>116589</epage><pages>116589-116589</pages><artnum>116589</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•Inulin, a fructan-type plant polysaccharide with average MW 5600−6300 g mol−1.•Inulin has functions of prebiotics, antioxidant, reglualting lipid metabolism, etc.•Inulin can be a carrier for colon/tumor-targeting drug delivery.
Inulin (IN), a fructan-type plant polysaccharide, is widely found in nature. The major plant sources of IN include chicory, Jerusalem artichoke, dahlia etc. Studies have found that IN possessed a wide array of biological activities, e.g. as a prebiotic to improve the intestinal microbe environment, regulating blood sugar, regulating blood lipids, antioxidant, anticancer, immune regulation and so on. Currently, IN is widely used in the food and pharmaceutical industries. IN can be used as thickener, fat replacer, sweetener and water retaining agent in the food industry. IN also can be applied in the pharmaceutics as stabilizer, drug carrier, and auxiliary therapeutic agent for certain diseases such as constipation and diabetes. This paper reviews the physiological functions of IN and its applications in the field of pharmaceutics, analyzes its present research status and future research direction. This review will serve as a one-in-all resource for the researchers who are interested to work on IN.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32747248</pmid><doi>10.1016/j.carbpol.2020.116589</doi><tpages>1</tpages></addata></record> |
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| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - metabolism Antioxidants - pharmacology Blood Glucose - metabolism Cichorium intybus - chemistry Dahlia - chemistry Drug Carriers - chemistry Drug delivery Excipients - chemistry Excipients - isolation & purification Helianthus - chemistry Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Immunologic Factors - chemistry Immunologic Factors - isolation & purification Immunologic Factors - metabolism Immunologic Factors - pharmacology Inulin Inulin - chemistry Inulin - isolation & purification Inulin - metabolism Inulin - pharmacology Laxatives - chemistry Laxatives - isolation & purification Laxatives - metabolism Laxatives - pharmacology Lipids - blood Pharmaceutical applications Physiological functions Prebiotics Prebiotics - administration & dosage Stabilizer Sweetening Agents - chemistry Sweetening Agents - isolation & purification |
| title | The physiological functions and pharmaceutical applications of inulin: A review |
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