Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation

Homeostasis of intestinal stem cells (ISCs) is maintained by the orchestration of niche factors and intrinsic signaling networks. Here, we have found that deletion of Erk1 and Erk2 (Erk1/2) in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation an...

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Veröffentlicht in:	Development (Cambridge) 2020-09, Vol.147 (17)
Hauptverfasser:	Wei, Gaigai, Gao, Na, Chen, Jiwei, Fan, Lingling, Zeng, Zhiyang, Gao, Ganglong, Li, Liang, Fang, Guojiu, Hu, Kewen, Pang, Xiufeng, Fan, Heng-Yu, Clevers, Hans, Liu, Mingyao, Zhang, Xueli, Li, Dali
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Intestines - embryology MAP Kinase Signaling System Mice Mice, Knockout Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism raf Kinases - genetics raf Kinases - metabolism TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Wnt Signaling Pathway
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