Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis
Objective Surgical site infection (SSI) in colorectal cancer (CRC) has been a serious health care problem due to the delay of postoperative recovery. Our present study aimed to explore the risk factors for SSI in CRC patients. Methodology We have systematically searched these databases: PubMed, Coch...
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| Veröffentlicht in: | International journal of colorectal disease 2020-12, Vol.35 (12), p.2147-2156 |
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| container_issue | 12 |
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| container_title | International journal of colorectal disease |
| container_volume | 35 |
| creator | Xu, Zhaohui Qu, Hui Kanani, George Guo, Zhong Ren, Yanying Chen, Xin |
| description | Objective
Surgical site infection (SSI) in colorectal cancer (CRC) has been a serious health care problem due to the delay of postoperative recovery. Our present study aimed to explore the risk factors for SSI in CRC patients.
Methodology
We have systematically searched these databases: PubMed, Cochrane Library, and EMBASE as of March 2020 for studies on risk factors associated with SSI. Two investigators independently conducted the quality assessment and data extraction. Related risk factors in the studies were recorded, and a meta-analysis was performed.
Results
The search initially provided 2262 hits, 1913 studies were screened by two independent investigators. Finally, 15 studies were identified to be relevant for this meta-analysis. In total, 25 risk factors were eligible. Our meta-analysis indicated that eight factors (obesity, male sex, diabetes mellitus, ASA score ≥ 3, stoma creation, intraoperative complications, perioperative blood transfusion, and operation time ≥ 180 min) were significant risk factors for SSI, and one factor (laparoscopic procedure) was protective for SSI.
Conclusions
Effective interventions targeting the above factors may reduce the risk of developing postoperative SSI in CRC patients and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings. |
| doi_str_mv | 10.1007/s00384-020-03706-8 |
| format | Article |
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Surgical site infection (SSI) in colorectal cancer (CRC) has been a serious health care problem due to the delay of postoperative recovery. Our present study aimed to explore the risk factors for SSI in CRC patients.
Methodology
We have systematically searched these databases: PubMed, Cochrane Library, and EMBASE as of March 2020 for studies on risk factors associated with SSI. Two investigators independently conducted the quality assessment and data extraction. Related risk factors in the studies were recorded, and a meta-analysis was performed.
Results
The search initially provided 2262 hits, 1913 studies were screened by two independent investigators. Finally, 15 studies were identified to be relevant for this meta-analysis. In total, 25 risk factors were eligible. Our meta-analysis indicated that eight factors (obesity, male sex, diabetes mellitus, ASA score ≥ 3, stoma creation, intraoperative complications, perioperative blood transfusion, and operation time ≥ 180 min) were significant risk factors for SSI, and one factor (laparoscopic procedure) was protective for SSI.
Conclusions
Effective interventions targeting the above factors may reduce the risk of developing postoperative SSI in CRC patients and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-020-03706-8</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Blood transfusion ; Colorectal cancer ; Colorectal carcinoma ; Diabetes ; Diabetes mellitus ; Gastroenterology ; Health aspects ; Health care ; Hepatology ; Infection ; Internal Medicine ; Laparoscopy ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Meta-analysis ; Patients ; Proctology ; Quality control ; Review ; Risk factors ; Surgery ; Surgical site infections</subject><ispartof>International journal of colorectal disease, 2020-12, Vol.35 (12), p.2147-2156</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-16988778a4e202acb008d186efc374a10fdf5153701b256877b39d1f925bafed3</citedby><cites>FETCH-LOGICAL-c485t-16988778a4e202acb008d186efc374a10fdf5153701b256877b39d1f925bafed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-020-03706-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-020-03706-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Xu, Zhaohui</creatorcontrib><creatorcontrib>Qu, Hui</creatorcontrib><creatorcontrib>Kanani, George</creatorcontrib><creatorcontrib>Guo, Zhong</creatorcontrib><creatorcontrib>Ren, Yanying</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><title>Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><description>Objective
Surgical site infection (SSI) in colorectal cancer (CRC) has been a serious health care problem due to the delay of postoperative recovery. Our present study aimed to explore the risk factors for SSI in CRC patients.
Methodology
We have systematically searched these databases: PubMed, Cochrane Library, and EMBASE as of March 2020 for studies on risk factors associated with SSI. Two investigators independently conducted the quality assessment and data extraction. Related risk factors in the studies were recorded, and a meta-analysis was performed.
Results
The search initially provided 2262 hits, 1913 studies were screened by two independent investigators. Finally, 15 studies were identified to be relevant for this meta-analysis. In total, 25 risk factors were eligible. Our meta-analysis indicated that eight factors (obesity, male sex, diabetes mellitus, ASA score ≥ 3, stoma creation, intraoperative complications, perioperative blood transfusion, and operation time ≥ 180 min) were significant risk factors for SSI, and one factor (laparoscopic procedure) was protective for SSI.
Conclusions
Effective interventions targeting the above factors may reduce the risk of developing postoperative SSI in CRC patients and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings.</description><subject>Blood transfusion</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Hepatology</subject><subject>Infection</subject><subject>Internal Medicine</subject><subject>Laparoscopy</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Patients</subject><subject>Proctology</subject><subject>Quality control</subject><subject>Review</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Surgical site infections</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhoMoOK7-AU8BL16ym6_upL0ti1-w4MU9h5p0ZcjanYxJRpl_b8YRFmWRHEIlz1NU8hLyWvBLwbm5qpwrqxmXnHFl-MjsE7IRWkkm5Cifkg0XZmJiGuxz8qLWe97r0egNWe_2MzSkOdES6zcawLdcKs2B1kPZRQ8LrbEDMQX0LXYuJurzkksv-6WH5LG8o0DrsTZcoUVPC_6I-JNCmumKDRgkWI411pfkWYCl4qs_-wW5-_D-680ndvvl4-eb61vmtR0aE-NkrTEWNEouwW85t7OwIwavjAbBwxwGMfSHiq0cxo5u1TSLMMlhCwFndUHenvvuS_5-wNrcGqvHZYGE-VCd1IqrcdKWd_TNP-h9PpQ-74kyylgzKP1A7WBB1_8itwL-1NRdG6G1NaMynbp8hOprxjX6nDDEfv6XIM-CL7nWgsHtS1yhHJ3g7hSsOwfrerDud7DOdkmdpdrhtMPyMPF_rF8rmaRu</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Xu, Zhaohui</creator><creator>Qu, Hui</creator><creator>Kanani, George</creator><creator>Guo, Zhong</creator><creator>Ren, Yanying</creator><creator>Chen, Xin</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis</title><author>Xu, Zhaohui ; Qu, Hui ; Kanani, George ; Guo, Zhong ; Ren, Yanying ; Chen, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-16988778a4e202acb008d186efc374a10fdf5153701b256877b39d1f925bafed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood transfusion</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Hepatology</topic><topic>Infection</topic><topic>Internal Medicine</topic><topic>Laparoscopy</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Patients</topic><topic>Proctology</topic><topic>Quality control</topic><topic>Review</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Surgical site infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Zhaohui</creatorcontrib><creatorcontrib>Qu, Hui</creatorcontrib><creatorcontrib>Kanani, George</creatorcontrib><creatorcontrib>Guo, Zhong</creatorcontrib><creatorcontrib>Ren, Yanying</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Zhaohui</au><au>Qu, Hui</au><au>Kanani, George</au><au>Guo, Zhong</au><au>Ren, Yanying</au><au>Chen, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>35</volume><issue>12</issue><spage>2147</spage><epage>2156</epage><pages>2147-2156</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Objective
Surgical site infection (SSI) in colorectal cancer (CRC) has been a serious health care problem due to the delay of postoperative recovery. Our present study aimed to explore the risk factors for SSI in CRC patients.
Methodology
We have systematically searched these databases: PubMed, Cochrane Library, and EMBASE as of March 2020 for studies on risk factors associated with SSI. Two investigators independently conducted the quality assessment and data extraction. Related risk factors in the studies were recorded, and a meta-analysis was performed.
Results
The search initially provided 2262 hits, 1913 studies were screened by two independent investigators. Finally, 15 studies were identified to be relevant for this meta-analysis. In total, 25 risk factors were eligible. Our meta-analysis indicated that eight factors (obesity, male sex, diabetes mellitus, ASA score ≥ 3, stoma creation, intraoperative complications, perioperative blood transfusion, and operation time ≥ 180 min) were significant risk factors for SSI, and one factor (laparoscopic procedure) was protective for SSI.
Conclusions
Effective interventions targeting the above factors may reduce the risk of developing postoperative SSI in CRC patients and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00384-020-03706-8</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| subjects | Blood transfusion Colorectal cancer Colorectal carcinoma Diabetes Diabetes mellitus Gastroenterology Health aspects Health care Hepatology Infection Internal Medicine Laparoscopy Medical research Medicine Medicine & Public Health Medicine, Experimental Meta-analysis Patients Proctology Quality control Review Risk factors Surgery Surgical site infections |
| title | Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis |
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