From the past, a long way to future challenges for a greater control of tuberculosis
Tuberculosis (TB) and humans have coexisted for more than 40,000 years; however TB remains a global threat to human kind. The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment cha...
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| Veröffentlicht in: | Tuberculosis (Edinburgh, Scotland) Scotland), 2020-07, Vol.123, p.101948-101948, Article 101948 |
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| container_title | Tuberculosis (Edinburgh, Scotland) |
| container_volume | 123 |
| creator | Villa, Simone Riccardi, Niccolò Canetti, Diana Alagna, Riccardo Castellotti, Paola Ferrarese, Maurizio Cirillo, Daniela Barberis, Ilaria Bragazzi, Nicola Luigi Gazzaniga, Valentina Ricucci, Valentina Codecasa, Luigi Ruffo Besozzi, Giorgio Martini, Mariano |
| description | Tuberculosis (TB) and humans have coexisted for more than 40,000 years; however TB remains a global threat to human kind. The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment challenges. Furthermore, TB has formed also an alliance with human immunodeficiency virus; in this way the poorest populations are most affected.
The current vaccine planning activity includes 14 new vaccines against TB (11 of those in the phaseII/III) developed with different techniques.
Now, more than ever, new anti-TB drugs and new anti-TB regimens are urgently required as well as universal health care and social protection in order to tackle down both hard to treat TB and the social determinants of TB. Coordinated actions and sharing of information are needed to aspire everywhere to the best clinical practices and improve quality of life of patients and their families. |
| doi_str_mv | 10.1016/j.tube.2020.101948 |
| format | Article |
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The current vaccine planning activity includes 14 new vaccines against TB (11 of those in the phaseII/III) developed with different techniques.
Now, more than ever, new anti-TB drugs and new anti-TB regimens are urgently required as well as universal health care and social protection in order to tackle down both hard to treat TB and the social determinants of TB. Coordinated actions and sharing of information are needed to aspire everywhere to the best clinical practices and improve quality of life of patients and their families.</description><identifier>ISSN: 1472-9792</identifier><identifier>EISSN: 1873-281X</identifier><identifier>DOI: 10.1016/j.tube.2020.101948</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Drug resistance ; Drugs ; End TB ; Evolution of TB ; Future challenges ; HIV ; Human immunodeficiency virus ; Past ; Quality of life ; Tuberculosis ; Vaccines ; Viruses</subject><ispartof>Tuberculosis (Edinburgh, Scotland), 2020-07, Vol.123, p.101948-101948, Article 101948</ispartof><rights>2020</rights><rights>Copyright Elsevier Science Ltd. Jul 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-8d2ff7ca49aa28ca8ed97163e2caf46b2d80cbe48e10b21cf0a2a47252a9cafd3</citedby><cites>FETCH-LOGICAL-c361t-8d2ff7ca49aa28ca8ed97163e2caf46b2d80cbe48e10b21cf0a2a47252a9cafd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tube.2020.101948$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Villa, Simone</creatorcontrib><creatorcontrib>Riccardi, Niccolò</creatorcontrib><creatorcontrib>Canetti, Diana</creatorcontrib><creatorcontrib>Alagna, Riccardo</creatorcontrib><creatorcontrib>Castellotti, Paola</creatorcontrib><creatorcontrib>Ferrarese, Maurizio</creatorcontrib><creatorcontrib>Cirillo, Daniela</creatorcontrib><creatorcontrib>Barberis, Ilaria</creatorcontrib><creatorcontrib>Bragazzi, Nicola Luigi</creatorcontrib><creatorcontrib>Gazzaniga, Valentina</creatorcontrib><creatorcontrib>Ricucci, Valentina</creatorcontrib><creatorcontrib>Codecasa, Luigi Ruffo</creatorcontrib><creatorcontrib>Besozzi, Giorgio</creatorcontrib><creatorcontrib>Martini, Mariano</creatorcontrib><title>From the past, a long way to future challenges for a greater control of tuberculosis</title><title>Tuberculosis (Edinburgh, Scotland)</title><description>Tuberculosis (TB) and humans have coexisted for more than 40,000 years; however TB remains a global threat to human kind. The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment challenges. Furthermore, TB has formed also an alliance with human immunodeficiency virus; in this way the poorest populations are most affected.
The current vaccine planning activity includes 14 new vaccines against TB (11 of those in the phaseII/III) developed with different techniques.
Now, more than ever, new anti-TB drugs and new anti-TB regimens are urgently required as well as universal health care and social protection in order to tackle down both hard to treat TB and the social determinants of TB. Coordinated actions and sharing of information are needed to aspire everywhere to the best clinical practices and improve quality of life of patients and their families.</description><subject>Drug resistance</subject><subject>Drugs</subject><subject>End TB</subject><subject>Evolution of TB</subject><subject>Future challenges</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Past</subject><subject>Quality of life</subject><subject>Tuberculosis</subject><subject>Vaccines</subject><subject>Viruses</subject><issn>1472-9792</issn><issn>1873-281X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kDFPwzAQhS0EEqXwB5gssTCQYjtuYkssCFFAqsRSJDbLcc5tojQutgPqv8clTAxMdzp97-7eQ-iSkhkltLhtZ3GoYMYI-xlILo7QhIoyz5ig78ep5yXLZCnZKToLoSVJRASZoNXCuy2OG8A7HeIN1rhz_Rp_6T2ODtshDh6w2eiug34NAVvnE7P2oCN4bFwfveuws_hw35uhc6EJ5-jE6i7AxW-dorfF4-rhOVu-Pr083C8zkxc0ZqJm1pZGc6k1E0YLqGVJixyY0ZYXFasFMRVwAZRUjBpLNNPJx5xpmYg6n6Lrce_Ou48BQlTbJhjoOt2DG4JiPCeUEFnyhF79QVs3-D59lyhelIzJfJ4oNlLGuxA8WLXzzVb7vaJEHYJWrToYVYeg1Rh0Et2NIkhWPxvwKpgGegN148FEVbvmP_k3OI-HCA</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Villa, Simone</creator><creator>Riccardi, Niccolò</creator><creator>Canetti, Diana</creator><creator>Alagna, Riccardo</creator><creator>Castellotti, Paola</creator><creator>Ferrarese, Maurizio</creator><creator>Cirillo, Daniela</creator><creator>Barberis, Ilaria</creator><creator>Bragazzi, Nicola Luigi</creator><creator>Gazzaniga, Valentina</creator><creator>Ricucci, Valentina</creator><creator>Codecasa, Luigi Ruffo</creator><creator>Besozzi, Giorgio</creator><creator>Martini, Mariano</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>202007</creationdate><title>From the past, a long way to future challenges for a greater control of tuberculosis</title><author>Villa, Simone ; 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The international community has developed new tools for early detection, but TB strains evolved acquiring resistance to first-line therapeutic drugs with increasing treatment challenges. Furthermore, TB has formed also an alliance with human immunodeficiency virus; in this way the poorest populations are most affected.
The current vaccine planning activity includes 14 new vaccines against TB (11 of those in the phaseII/III) developed with different techniques.
Now, more than ever, new anti-TB drugs and new anti-TB regimens are urgently required as well as universal health care and social protection in order to tackle down both hard to treat TB and the social determinants of TB. Coordinated actions and sharing of information are needed to aspire everywhere to the best clinical practices and improve quality of life of patients and their families.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.tube.2020.101948</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 1472-9792 |
| ispartof | Tuberculosis (Edinburgh, Scotland), 2020-07, Vol.123, p.101948-101948, Article 101948 |
| issn | 1472-9792 1873-281X |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Drug resistance Drugs End TB Evolution of TB Future challenges HIV Human immunodeficiency virus Past Quality of life Tuberculosis Vaccines Viruses |
| title | From the past, a long way to future challenges for a greater control of tuberculosis |
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