Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma

To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Prospective, observational study. Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Patients received optic disc photograp...

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Veröffentlicht in:Ophthalmology. Glaucoma 2020-11, Vol.3 (6), p.443-452
Hauptverfasser: An, Dong, House, Philip, Barry, Christopher, Turpin, Andrew, McKendrick, Allison M., Chauhan, Balwantray C., Manners, Siobhan, Graham, Stuart, Yu, Dao-Yi, Morgan, William H.
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container_end_page 452
container_issue 6
container_start_page 443
container_title Ophthalmology. Glaucoma
container_volume 3
creator An, Dong
House, Philip
Barry, Christopher
Turpin, Andrew
McKendrick, Allison M.
Chauhan, Balwantray C.
Manners, Siobhan
Graham, Stuart
Yu, Dao-Yi
Morgan, William H.
description To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Prospective, observational study. Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P < 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P < 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P 8 ODH had faster VF progression than all other groups (all P < 0.001). High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. In addition, ODH occurring in different sectors in the same eye was more strongly associated with greater global VF progression compared with those occurring within the same sector.
doi_str_mv 10.1016/j.ogla.2020.06.004
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Prospective, observational study. Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P &lt; 0.05) negative slope within that sector. The association between ODH and VF progression rate globally and within a sector was calculated using linear mixed modeling. Global and sectoral VF progression, ODH frequency, and ODH recurrence (globally and sectoral) and its association with VF progression rate. A total of 151 eyes from 77 patients completed the study with mean follow-up of 64 months, 20 disc photographs, and 16 VF tests. With global VF analysis, eyes with ODH in 2 different sectors of the disc had worse progression rate than eyes with ODH in 1 sector (P = 0.012) and eyes with no ODH (P &lt; 0.001). Regarding the largest sectoral VF progression, sectors with 1 ODH had a faster VF progression rate than those with no ODH (P &lt; 0.017) and progressed at a similar rate to those with 2 to 8 ODH (P = 0.592). Sectors with &gt;8 ODH had faster VF progression than all other groups (all P &lt; 0.001). High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. 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Glaucoma</title><addtitle>Ophthalmol Glaucoma</addtitle><description>To investigate the association among optic disc hemorrhage (ODH) recurrence, location, and visual field (VF) progression. Prospective, observational study. Patients with bilateral glaucoma or unilateral glaucoma with a fellow glaucoma suspect eye were enrolled. Patients received optic disc photography every 3 months and VF testing every 4 months. The disc was partitioned into 8 sectors to match 8 visual field (VF) sectors. The frequency of ODH in each sector was quantified over an average of 64 months. Global VF progression rate was calculated using linear regression on mean deviation. Sectoral progression rate was calculated using linear regression on the sensitivity at each VF location over time and then selecting the largest and second largest significant (P &lt; 0.05) negative slope within that sector. 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High-frequency ODH within optic disc sectors, equivalent to detecting ODH in 45% of 3 monthly eye examination visits, was associated with significantly worse VF progression than sectors with moderate or only 1 observed ODH. 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title Recurrent Optic Disc Hemorrhage and Its Association with Visual Field Deterioration in Glaucoma
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