Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats
•Congenital transmission in different goat families occurred over several generations.•Neospora caninum infection persisted though-out generations in goats.•Some Neospora caninum seropositive goats gave birth to a seronegative kids. Neospora caninum is a protozoan that is considered an important age...
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| Veröffentlicht in: | Veterinary parasitology 2020-08, Vol.284, p.109191-109191, Article 109191 |
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| creator | de Oliveira Junior, Ivam Moreira Mesquita, Lucas Emanuel dos Santos Miranda, Débora Nunes Procópio Gomes, Thaís Aurora Vasconcelos, Beatriz Ketelin Sousa Penha, Letícia Cristine Silveira, Luísa Carolina Silva Redondo, Anthony René Ramos Costa, Rafael Carneiro Bruhn, Fábio Raphael Pascoti Raymundo, Djeison Lutier Wouters, Angelica T. Barth Wouters, Flademir Varaschin, Mary Suzan |
| description | •Congenital transmission in different goat families occurred over several generations.•Neospora caninum infection persisted though-out generations in goats.•Some Neospora caninum seropositive goats gave birth to a seronegative kids.
Neospora caninum is a protozoan that is considered an important agent of reproductive disorders in ruminants worldwide, and vertical transmission is the main form of infection and maintenance of neosporosis in herds. In goats, there have been no studies that have evaluated the transmission of N. caninum between successive generations. Thus, the objective of this study was to evaluate, through IFAT and PCR, the endogenous transplacental transmission of N. caninum in up to five generations of six families of dairy goats naturally infected by the parasite and whether it was possible for dairy goats to become free of infection over successive generations. Ninety-five serum samples from positive animals and 75 samples from negative animals were analyzed for N. caninum. Of the 95 samples analyzed, 93 contained anti-N. caninum antibodies (97.8 %). Titers of anti-N. caninum antibodies varied (increasing or decreasing) in the offspring; however, with an increase in the number of the goat generations, the offspring tended to have lower titers (p = 0.021) at the day of birth. Reproductive disorders such as abortions, stillbirth or fetal retention occurred at a rate of 10.4 % and were not influenced by the mother's titer of anti-N. caninum antibodies at the day of parturition or abortion. The results showed that infection by N. caninum persists throughout generations in congenitally infected goats. |
| doi_str_mv | 10.1016/j.vetpar.2020.109191 |
| format | Article |
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Neospora caninum is a protozoan that is considered an important agent of reproductive disorders in ruminants worldwide, and vertical transmission is the main form of infection and maintenance of neosporosis in herds. In goats, there have been no studies that have evaluated the transmission of N. caninum between successive generations. Thus, the objective of this study was to evaluate, through IFAT and PCR, the endogenous transplacental transmission of N. caninum in up to five generations of six families of dairy goats naturally infected by the parasite and whether it was possible for dairy goats to become free of infection over successive generations. Ninety-five serum samples from positive animals and 75 samples from negative animals were analyzed for N. caninum. Of the 95 samples analyzed, 93 contained anti-N. caninum antibodies (97.8 %). Titers of anti-N. caninum antibodies varied (increasing or decreasing) in the offspring; however, with an increase in the number of the goat generations, the offspring tended to have lower titers (p = 0.021) at the day of birth. Reproductive disorders such as abortions, stillbirth or fetal retention occurred at a rate of 10.4 % and were not influenced by the mother's titer of anti-N. caninum antibodies at the day of parturition or abortion. The results showed that infection by N. caninum persists throughout generations in congenitally infected goats.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/j.vetpar.2020.109191</identifier><identifier>PMID: 32739750</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibodies, Protozoan - blood ; Apicomplexa ; Coccidiosis - blood ; Coccidiosis - transmission ; Coccidiosis - veterinary ; Female ; Fluorescent Antibody Technique, Indirect ; Goat Diseases - parasitology ; Goat Diseases - transmission ; Goats ; IFAT ; Infectious Disease Transmission, Vertical - veterinary ; Maternal-Fetal Exchange ; Neospora ; Neosporosis ; PCR ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications, Parasitic - blood ; Pregnancy Complications, Parasitic - veterinary ; Small ruminant</subject><ispartof>Veterinary parasitology, 2020-08, Vol.284, p.109191-109191, Article 109191</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-14d95d5bb03a78ed047b0bcc2063d9cecef136f7dc908f4971b50728a2f1c07a3</citedby><cites>FETCH-LOGICAL-c408t-14d95d5bb03a78ed047b0bcc2063d9cecef136f7dc908f4971b50728a2f1c07a3</cites><orcidid>0000-0003-4149-5006 ; 0000-0003-3158-2659</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304401720301710$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32739750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira Junior, Ivam Moreira</creatorcontrib><creatorcontrib>Mesquita, Lucas Emanuel dos Santos</creatorcontrib><creatorcontrib>Miranda, Débora Nunes Procópio</creatorcontrib><creatorcontrib>Gomes, Thaís Aurora</creatorcontrib><creatorcontrib>Vasconcelos, Beatriz Ketelin Sousa</creatorcontrib><creatorcontrib>Penha, Letícia Cristine</creatorcontrib><creatorcontrib>Silveira, Luísa Carolina Silva</creatorcontrib><creatorcontrib>Redondo, Anthony René Ramos</creatorcontrib><creatorcontrib>Costa, Rafael Carneiro</creatorcontrib><creatorcontrib>Bruhn, Fábio Raphael Pascoti</creatorcontrib><creatorcontrib>Raymundo, Djeison Lutier</creatorcontrib><creatorcontrib>Wouters, Angelica T. Barth</creatorcontrib><creatorcontrib>Wouters, Flademir</creatorcontrib><creatorcontrib>Varaschin, Mary Suzan</creatorcontrib><title>Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>•Congenital transmission in different goat families occurred over several generations.•Neospora caninum infection persisted though-out generations in goats.•Some Neospora caninum seropositive goats gave birth to a seronegative kids.
Neospora caninum is a protozoan that is considered an important agent of reproductive disorders in ruminants worldwide, and vertical transmission is the main form of infection and maintenance of neosporosis in herds. In goats, there have been no studies that have evaluated the transmission of N. caninum between successive generations. Thus, the objective of this study was to evaluate, through IFAT and PCR, the endogenous transplacental transmission of N. caninum in up to five generations of six families of dairy goats naturally infected by the parasite and whether it was possible for dairy goats to become free of infection over successive generations. Ninety-five serum samples from positive animals and 75 samples from negative animals were analyzed for N. caninum. Of the 95 samples analyzed, 93 contained anti-N. caninum antibodies (97.8 %). Titers of anti-N. caninum antibodies varied (increasing or decreasing) in the offspring; however, with an increase in the number of the goat generations, the offspring tended to have lower titers (p = 0.021) at the day of birth. Reproductive disorders such as abortions, stillbirth or fetal retention occurred at a rate of 10.4 % and were not influenced by the mother's titer of anti-N. caninum antibodies at the day of parturition or abortion. The results showed that infection by N. caninum persists throughout generations in congenitally infected goats.</description><subject>Animals</subject><subject>Antibodies, Protozoan - blood</subject><subject>Apicomplexa</subject><subject>Coccidiosis - blood</subject><subject>Coccidiosis - transmission</subject><subject>Coccidiosis - veterinary</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Goat Diseases - parasitology</subject><subject>Goat Diseases - transmission</subject><subject>Goats</subject><subject>IFAT</subject><subject>Infectious Disease Transmission, Vertical - veterinary</subject><subject>Maternal-Fetal Exchange</subject><subject>Neospora</subject><subject>Neosporosis</subject><subject>PCR</subject><subject>Polymerase Chain Reaction</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - blood</subject><subject>Pregnancy Complications, Parasitic - veterinary</subject><subject>Small ruminant</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVoaDZJ3yAUH3vxdmTJK-tSKCFNCqG9JGchj8ZBi1dyJXshb18tTnvMSWj45h_-j7EbDlsOfPd1vz3SPNm0baA5jTTX_IxteKdE3bQtfGAbECBrCVxdsMuc9wAgYac-sgvRKKFVCxuW74KLLxTikqs52ZCn0SKF2Y7r9-Bz9jFUcah-UcxTTLZCG3xYDpUPVV4QqRBHqkoIJTsXOJ9ojKFMfAkaXws5EM7kqpdo53zNzgc7Zvr09l6x5x93T7cP9ePv-5-33x9rlNDNNZdOt67texBWdeRAqh56xAZ2wmkkpIGL3aAcaugGqRXvW1BNZ5uBIygrrtiXNXdK8c9CeTalDdI42kClr2mkANC6U7ygckUxxZwTDWZK_mDTq-FgTrrN3qy6zUm3WXWXtc9vF5b-QO7_0j-_Bfi2AlR6Hj0lk9FTQHI-FSPGRf_-hb-A6pYp</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>de Oliveira Junior, Ivam Moreira</creator><creator>Mesquita, Lucas Emanuel dos Santos</creator><creator>Miranda, Débora Nunes Procópio</creator><creator>Gomes, Thaís Aurora</creator><creator>Vasconcelos, Beatriz Ketelin Sousa</creator><creator>Penha, Letícia Cristine</creator><creator>Silveira, Luísa Carolina Silva</creator><creator>Redondo, Anthony René Ramos</creator><creator>Costa, Rafael Carneiro</creator><creator>Bruhn, Fábio Raphael Pascoti</creator><creator>Raymundo, Djeison Lutier</creator><creator>Wouters, Angelica T. 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Barth</creatorcontrib><creatorcontrib>Wouters, Flademir</creatorcontrib><creatorcontrib>Varaschin, Mary Suzan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira Junior, Ivam Moreira</au><au>Mesquita, Lucas Emanuel dos Santos</au><au>Miranda, Débora Nunes Procópio</au><au>Gomes, Thaís Aurora</au><au>Vasconcelos, Beatriz Ketelin Sousa</au><au>Penha, Letícia Cristine</au><au>Silveira, Luísa Carolina Silva</au><au>Redondo, Anthony René Ramos</au><au>Costa, Rafael Carneiro</au><au>Bruhn, Fábio Raphael Pascoti</au><au>Raymundo, Djeison Lutier</au><au>Wouters, Angelica T. Barth</au><au>Wouters, Flademir</au><au>Varaschin, Mary Suzan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>2020-08</date><risdate>2020</risdate><volume>284</volume><spage>109191</spage><epage>109191</epage><pages>109191-109191</pages><artnum>109191</artnum><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>•Congenital transmission in different goat families occurred over several generations.•Neospora caninum infection persisted though-out generations in goats.•Some Neospora caninum seropositive goats gave birth to a seronegative kids.
Neospora caninum is a protozoan that is considered an important agent of reproductive disorders in ruminants worldwide, and vertical transmission is the main form of infection and maintenance of neosporosis in herds. In goats, there have been no studies that have evaluated the transmission of N. caninum between successive generations. Thus, the objective of this study was to evaluate, through IFAT and PCR, the endogenous transplacental transmission of N. caninum in up to five generations of six families of dairy goats naturally infected by the parasite and whether it was possible for dairy goats to become free of infection over successive generations. Ninety-five serum samples from positive animals and 75 samples from negative animals were analyzed for N. caninum. Of the 95 samples analyzed, 93 contained anti-N. caninum antibodies (97.8 %). Titers of anti-N. caninum antibodies varied (increasing or decreasing) in the offspring; however, with an increase in the number of the goat generations, the offspring tended to have lower titers (p = 0.021) at the day of birth. Reproductive disorders such as abortions, stillbirth or fetal retention occurred at a rate of 10.4 % and were not influenced by the mother's titer of anti-N. caninum antibodies at the day of parturition or abortion. The results showed that infection by N. caninum persists throughout generations in congenitally infected goats.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32739750</pmid><doi>10.1016/j.vetpar.2020.109191</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4149-5006</orcidid><orcidid>https://orcid.org/0000-0003-3158-2659</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Veterinary parasitology, 2020-08, Vol.284, p.109191-109191, Article 109191 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antibodies, Protozoan - blood Apicomplexa Coccidiosis - blood Coccidiosis - transmission Coccidiosis - veterinary Female Fluorescent Antibody Technique, Indirect Goat Diseases - parasitology Goat Diseases - transmission Goats IFAT Infectious Disease Transmission, Vertical - veterinary Maternal-Fetal Exchange Neospora Neosporosis PCR Polymerase Chain Reaction Pregnancy Pregnancy Complications, Parasitic - blood Pregnancy Complications, Parasitic - veterinary Small ruminant |
| title | Endogenous transplacental transmission of Neospora caninum in successive generations of congenitally infected goats |
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