5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors

[Display omitted] (2S,3R,4R,5S,6R)-2-Aryl-5,5-difluoro-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diols and (2S,3R,4R,5S,6R)-2-aryl-5-fluoro-5-methyl-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diols were discovered as dual inhibitors of sodium glucose co-transporter proteins (e.g. SGLT1 and SGLT2) throu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-09, Vol.30 (17), p.127387-127387, Article 127387
Hauptverfasser:	Xu, Guozhang, Du, Fuyong, Kuo, Gee-Hong, Xu, June Zhi, Liang, Yin, Demarest, Keith, Gaul, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioisostere C-Aryl Glucoside Diabetes Fluorination Glucose transporter SGLT1 inhibitor SGLT2 inhibitor
Online-Zugang:	Volltext
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