Tuberous sclerosis 1 (Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis

Energy reprogramming to glycolysis is closely associated with the development of chronic kidney disease. As an important negative regulatory factor of the mammalian target of rapamycin complex 1 (mTORC1) signal, tuberous sclerosis complex 1 (Tsc1) is also a key regulatory point of glycolysis. Here,...

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Veröffentlicht in:	Kidney international 2020-09, Vol.98 (3), p.686-698
Hauptverfasser:	Cao, Hongdi, Luo, Jing, Zhang, Yu, Mao, Xiaoming, Wen, Ping, Ding, Hao, Xu, Jing, Sun, Qi, He, Weichun, Dai, Chunsun, Zen, Ke, Zhou, Yang, Yang, Junwei, Jiang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Epithelial Cells Fibrosis Glycolysis Kidney - pathology Mechanistic Target of Rapamycin Complex 1 - metabolism Mice mTOR signaling Rats renal fibrosis Tuberous Sclerosis - metabolism Tuberous Sclerosis - pathology Tuberous Sclerosis Complex 1 Protein tubular epithelial cells
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