Natural killer and NKT cells in the male reproductive tract

•Infection and inflammation of the genital tract are thought to be the primary etiology of male infertility.•Natural killer (NK) and NKT cells play a pivotal role in the innate and adaptive immune responses.•NK and NKT cells maintain immune privilege and pathological antigens and cancerous cells in testis.•Indication of tumor recurrence (NK) and remodeling the immune microenvironment (NK T) in prostate cancer.•Proliferation of NK and NKT cells impair sperm quality and functions in semen. Natural killer (NK) cells are important effector lymphocytes that play a pivotal role in the innate and adaptive immune responses to tumors and viral infection. NKT cells are a heterogeneous group of T cells that share properties with both T cells and NK cells. They display immunoregulatory properties as they facilitate the cell-mediated immune response to tumors and infectious diseases, and inhibit cell-mediated immunity associated with autoimmune diseases and allograft rejection. However, the roles of NK and NKT cells in the male reproductive tract remain largely unexplored, in particular, NKT cells, tissue distribution, and state of health or disease. Infection and inflammation of the male genital tract are thought to be the primary etiological factors of male infertility. In this review, we considered this complex and rapidly growing field. We summarize the recent findings and the characterization and roles of NK and NKT cells in the male reproductive tract, including the testis, epididymis, prostate, seminal vesicle, and semen, to enhance our understanding of the immunological mechanisms of male infertility and for the design effective vaccines for male reproductive health in the future.