Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction

In vitro to in vivo extrapolation (IVIVE) to predict human hepatic clearance, including metabolism and transport, requires extensive experimental resources. In addition, there may be technical challenges to measure low clearance values. Therefore, prospective identification of rate-determining step(...

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Veröffentlicht in:	Drug metabolism and disposition 2020-10, Vol.48 (10), p.849-860
Hauptverfasser:	Umehara, Kenichi, Cantrill, Carina, Wittwer, Matthias Beat, Di Lenarda, Elisa, Klammers, Florian, Ekiciler, Aynur, Parrott, Neil, Fowler, Stephen, Ullah, Mohammed
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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