TGF-β downregulation overcomes gemcitabine resistance in oral squamous cell carcinoma

OBJECTIVE: The aim of this study was to explore the mechanisms by which oral cancer acquires resistance to gemcitabine. METHODS: Oral squamous cell carcinoma (OSCC) cells were treated with gemcitabine upon infection or with a lentivirus harboring short hairpin RNA (shRNA) targeted to transforming gr...

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Veröffentlicht in:	Cancer biomarkers : section A of Disease markers 2020-01, Vol.29 (2), p.179-187
Hauptverfasser:	Xuan, Yun-Ze, Jin, Cheng-Ri, Yang, Kang-Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal research Cancer Cell death Enzyme-linked immunosorbent assay Gemcitabine Growth factors Oral cancer Oral squamous cell carcinoma Phosphorylation Resistance factors Ribonucleic acid RNA Squamous cell carcinoma Transforming growth factor-b
Online-Zugang:	Volltext
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