Identification of benzofused five-membered sultams, potent dual NOD1/NOD2 antagonists in vitro and in vivo

Nucleotide-binding oligomerization domain-containing proteins 1 and 2 play important roles in immune system activation. Recently, a shift has occurred due to the emerging knowledge that preventing nucleotide-binding oligomerization domains (NODs) signaling could facilitate the treatment of some canc...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-10, Vol.204, p.112575-112575, Article 112575
Hauptverfasser:	Ma, Yao, Li, Xueyuan, Pei, Yameng, Ye, Jingjia, Wei, Xiduan, Yang, Jingshu, Si, Guangxu, Tian, Jingyuan, Dong, Yi, Liu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Design Dual NOD1/NOD2 antagonist Five-membered sultams HEK293 Cells Humans Male MAPK signaling Mice Naphthalenesulfonates - chemistry Naphthalenesulfonates - pharmacology NF-κB signaling Nod1 Signaling Adaptor Protein - antagonists & inhibitors Nod1 Signaling Adaptor Protein - chemistry Nod1 Signaling Adaptor Protein - metabolism Nod2 Signaling Adaptor Protein - antagonists & inhibitors Nod2 Signaling Adaptor Protein - chemistry Nod2 Signaling Adaptor Protein - metabolism Protein Domains Signal Transduction - drug effects
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