Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively

The extraction process of Paeoniae radix alba polysaccharides (PRAP) was optimized as the liquid-solid ratio of 10.65 mL/g, the extraction time of 2.10 h, and the 2 extraction repetitions through a response surface methodology. The chemical profiles of the obtained PRAP were characterized by measuri...

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Veröffentlicht in:	International journal of biological macromolecules 2020-12, Vol.164, p.1554-1564
Hauptverfasser:	Wang, Siyu, Xu, Jiazhi, Wang, Changfu, Li, Jianchun, Wang, Qiuhong, Kuang, Haixue, Yang, Bingyou, Chen, Rongying, Luo, Zhongwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbohydrates - pharmacology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - metabolism Cytokines - metabolism Disease Models, Animal Drugs, Chinese Herbal - pharmacology Experimental autoimmune hepatitis Extraction process Hepatitis, Autoimmune - drug therapy Hepatitis, Autoimmune - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Inflammation - drug therapy Inflammation - metabolism Liver - drug effects Liver - metabolism Male Mice Oxidative Stress - drug effects Paeonia - chemistry Paeoniae radix alba polysaccharides Phenols - pharmacology Polysaccharides - pharmacology Signal Transduction - drug effects Spleen - drug effects Spleen - metabolism Uronic Acids - pharmacology
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