Dendritic cell engineered cTXN as new vaccine prospect against L. donovani

Dendritic cells (DCs), as antigen-presenting cells, can reportedly be infected withLeishmaniaparasites and hence provide a better option to trigger T-cell primary immune responses and immunological memory. We consistently primed DCs during culture with purified recombinant cytosolic tryparedoxin (rc...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2021-09, Vol.145, p.155208-155208, Article 155208
Hauptverfasser:	Suman, Shashi S., Kumar, Akhilesh, Singh, Ashish K., Amit, Ajay, Topno, R.K., Pandey, K., Das, V.N.R., Das, P., Ali, Vahab, Bimal, Sanjiva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cTXN Cytokines - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - parasitology GM-CSF IFN-γ IL-10 Immunity, Cellular - immunology Interleukin-10 - immunology Interleukin-12 - immunology Leishmania donovani - immunology Leishmaniasis Vaccines - immunology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Macrophages Macrophages - immunology Macrophages - parasitology Mice Mice, Inbred BALB C NFκβ Protozoan Proteins - immunology T-Lymphocytes - immunology T-Lymphocytes - parasitology Vaccine Visceral leishmaniasis
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