Targeting O-GlcNAcylation to develop novel therapeutics

O-linked β-D-N-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification (PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus, cytoplasm and mitochondria. Being a major “nutrient sensor” in cells, the O-GlcNAc pathway is sensitive to cellular...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular aspects of medicine 2021-06, Vol.79, p.100885-100885, Article 100885
Hauptverfasser:	Zhu, Yi, Hart, Gerald W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Diabetes Neurodegenerative disease O-GlcNAc Post-translational modification Protein function
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!