A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse

The loss of protein homeostasis (proteostasis) is a primary driver of age-related tissue dysfunction. Recent studies have revealed that the failure of proteostasis with age is triggered by developmental and reproductive cues that repress the activity of proteostasis-related pathways in early adultho...

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Veröffentlicht in:	Developmental cell 2020-09, Vol.54 (6), p.758-772.e5
Hauptverfasser:	Williams, Rhianna, Laskovs, Mihails, Williams, Rebecca I., Mahadevan, Ananya, Labbadia, John
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Animals Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Heat-Shock Response - physiology HSF1 mitochondria Mitochondria - metabolism molecular chaperones Molecular Chaperones - metabolism PP2A protein aggregation Proteome - metabolism proteostasis Proteostasis - physiology stress responses Stress, Physiological - physiology Transcription Factors - metabolism
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