Safety of push-dose phenylephrine in adult ICU patients
A PDP episode included both the initial administration of PDP and any subsequent doses of PDP given within a sixty-minute time-frame. [...]multiple PDP episodes could occur in a single patient. Episodes in which other bolus dose vasopressors, such as epinephrine, were used prior to phenylephrine wer...
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| Veröffentlicht in: | The American journal of emergency medicine 2020-09, Vol.38 (9), p.1778-1781 |
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| container_title | The American journal of emergency medicine |
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| creator | Kurish, Brian A. Alaniz, Cesar Miller, James T. Farina, Nicholas |
| description | A PDP episode included both the initial administration of PDP and any subsequent doses of PDP given within a sixty-minute time-frame. [...]multiple PDP episodes could occur in a single patient. Episodes in which other bolus dose vasopressors, such as epinephrine, were used prior to phenylephrine were also excluded.2.3 Data collection Patient demographic data collected included age, sex, weight, ICU type, and history of heart failure with reduced ( 180 mmHg or diastolic blood pressure > 110 mmHg), or bradycardia (heart rate 100 μg. Results of this comparison are shown in Table 3. |
| doi_str_mv | 10.1016/j.ajem.2020.05.087 |
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[...]multiple PDP episodes could occur in a single patient. Episodes in which other bolus dose vasopressors, such as epinephrine, were used prior to phenylephrine were also excluded.2.3 Data collection Patient demographic data collected included age, sex, weight, ICU type, and history of heart failure with reduced (<30%) left ventricular ejection fraction (LVEF). An interrater agreement test was not performed.2.4 Outcomes and statistics The primary outcome was a composite safety endpoint of new onset hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg), or bradycardia (heart rate < 50 bpm) at first vital signs recorded following initial PDP administration, a new extravasation event within 48 h following administration of PDP, and cardiac arrest within 10 min of initial PDP administration. The Naranjo algorithm scored this event 4, indicating this was a possible adverse drug reaction. Since the median initial PDP dose administered was 100 μg, patients receiving 100 μg or less of phenylephrine were compared to those who received >100 μg. Results of this comparison are shown in Table 3.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2020.05.087</identifier><language>eng</language><publisher>Philadelphia: Elsevier Inc</publisher><subject>Algorithms ; Automation ; Blood pressure ; Bradycardia ; Cardiac arrhythmia ; Congestive heart failure ; Data collection ; Drug dosages ; Ejection fraction ; Emergency medical care ; Epinephrine ; Extravasation ; Heart rate ; Hypertension ; Hypotension ; Intensive care ; Mortality ; Neurosurgery ; Patients ; Phenylephrine ; Ventricle ; Vital signs</subject><ispartof>The American journal of emergency medicine, 2020-09, Vol.38 (9), p.1778-1781</ispartof><rights>2020 Elsevier Inc.</rights><rights>2020. 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[...]multiple PDP episodes could occur in a single patient. Episodes in which other bolus dose vasopressors, such as epinephrine, were used prior to phenylephrine were also excluded.2.3 Data collection Patient demographic data collected included age, sex, weight, ICU type, and history of heart failure with reduced (<30%) left ventricular ejection fraction (LVEF). An interrater agreement test was not performed.2.4 Outcomes and statistics The primary outcome was a composite safety endpoint of new onset hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg), or bradycardia (heart rate < 50 bpm) at first vital signs recorded following initial PDP administration, a new extravasation event within 48 h following administration of PDP, and cardiac arrest within 10 min of initial PDP administration. The Naranjo algorithm scored this event 4, indicating this was a possible adverse drug reaction. Since the median initial PDP dose administered was 100 μg, patients receiving 100 μg or less of phenylephrine were compared to those who received >100 μg. Results of this comparison are shown in Table 3.</description><subject>Algorithms</subject><subject>Automation</subject><subject>Blood pressure</subject><subject>Bradycardia</subject><subject>Cardiac arrhythmia</subject><subject>Congestive heart failure</subject><subject>Data collection</subject><subject>Drug dosages</subject><subject>Ejection fraction</subject><subject>Emergency medical care</subject><subject>Epinephrine</subject><subject>Extravasation</subject><subject>Heart rate</subject><subject>Hypertension</subject><subject>Hypotension</subject><subject>Intensive care</subject><subject>Mortality</subject><subject>Neurosurgery</subject><subject>Patients</subject><subject>Phenylephrine</subject><subject>Ventricle</subject><subject>Vital signs</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kD1PwzAURS0EEqXwB5gisbAk-Dl2nEgsqOKjUiUG6Gy59ovqKE2CnSD13-OoTAxMbzn36r5DyC3QDCgUD02mGzxkjDKaUZHRUp6RBYicpSVIOCcLKnORFlLIS3IVQkMpABd8QeSHrnE8Jn2dDFPYp7YPmAx77I4tDnvvOkxcl2g7tWOyXm2TQY8OuzFck4tatwFvfu-SbF-eP1dv6eb9db162qQmL2BMOYJhdcmlLDW1jEppUdc5FlhaqCuQOeO7eqeZNRHQYuY4z7WwFRhZsXxJ7k-9g--_JgyjOrhgsG11h_0UFOOskrKAAiJ69wdt-sl3cV2keCU58HIuZCfK-D4Ej7UavDtof1RA1exSNWp2qWaXigoVXcbQ4ymE8dVvh14FEzUYtM6jGZXt3X_xHyFAe1U</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Kurish, Brian A.</creator><creator>Alaniz, Cesar</creator><creator>Miller, James T.</creator><creator>Farina, Nicholas</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Safety of push-dose phenylephrine in adult ICU patients</title><author>Kurish, Brian A. ; 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[...]multiple PDP episodes could occur in a single patient. Episodes in which other bolus dose vasopressors, such as epinephrine, were used prior to phenylephrine were also excluded.2.3 Data collection Patient demographic data collected included age, sex, weight, ICU type, and history of heart failure with reduced (<30%) left ventricular ejection fraction (LVEF). An interrater agreement test was not performed.2.4 Outcomes and statistics The primary outcome was a composite safety endpoint of new onset hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg), or bradycardia (heart rate < 50 bpm) at first vital signs recorded following initial PDP administration, a new extravasation event within 48 h following administration of PDP, and cardiac arrest within 10 min of initial PDP administration. The Naranjo algorithm scored this event 4, indicating this was a possible adverse drug reaction. Since the median initial PDP dose administered was 100 μg, patients receiving 100 μg or less of phenylephrine were compared to those who received >100 μg. Results of this comparison are shown in Table 3.</abstract><cop>Philadelphia</cop><pub>Elsevier Inc</pub><doi>10.1016/j.ajem.2020.05.087</doi><tpages>4</tpages></addata></record> |
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| source | Access via ScienceDirect (Elsevier); ProQuest Central |
| subjects | Algorithms Automation Blood pressure Bradycardia Cardiac arrhythmia Congestive heart failure Data collection Drug dosages Ejection fraction Emergency medical care Epinephrine Extravasation Heart rate Hypertension Hypotension Intensive care Mortality Neurosurgery Patients Phenylephrine Ventricle Vital signs |
| title | Safety of push-dose phenylephrine in adult ICU patients |
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