Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering

The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biomaterials 2020-10, Vol.256, p.120225-120225, Article 120225
Hauptverfasser:	Zhang, Kunyu, Chooi, Wai Hon, Liu, Shuang, Chin, Jiah Shin, Murray, Aoife, Nizetic, Dean, Cheng, Du, Chew, Sing Yian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Cas Systems CRISPR/Cas9 Electrospinning Gene delivery Genome editing Nanofibers Nerve regeneration Peptides Rats Tissue Engineering
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!