Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease
Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD. M...
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| Veröffentlicht in: | Journal of pediatric surgery 2021-04, Vol.56 (4), p.738-744 |
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| container_title | Journal of pediatric surgery |
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| creator | Wang, Nan Wang, Jiazheng Zhang, Tian Huang, Liufang Yan, Weihui Lu, Lina Jia, Jie Tao, Yijing Cai, Wei Wang, Ying |
| description | Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD.
Male 4-week-old Sprague Dawley rats received either total parenteral nutrition or standard chow with 0.9% saline for 7 days. The taxonomic composition of cecal microbiota and its functional composition associated with bile acid metabolism were measured.
There were differences in taxonomic composition between the two groups. The abundance of the secondary bile acid biosynthesis pathway was higher in the TPN group (p |
| doi_str_mv | 10.1016/j.jpedsurg.2020.06.035 |
| format | Article |
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Male 4-week-old Sprague Dawley rats received either total parenteral nutrition or standard chow with 0.9% saline for 7 days. The taxonomic composition of cecal microbiota and its functional composition associated with bile acid metabolism were measured.
There were differences in taxonomic composition between the two groups. The abundance of the secondary bile acid biosynthesis pathway was higher in the TPN group (p < 0.05) with an increase in the percentage of bacteria expressing 7-alpha-hydroxysteroid dehydrogenase (p < 0.05). The abundance of enzymes associated with bile salt hydrolase was also higher (p < 0.05) in the TPN group. The TPN group showed a distinct bile acid profile characterized by a higher ratio of secondary bile acids to primary bile acids.
The alteration of bile acid-associated microbiota may lead to increased secondary bile acid production in a rat model of PNALD.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/j.jpedsurg.2020.06.035</identifier><identifier>PMID: 32732165</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bile acid profile ; Cecal microbiome ; Liver dysfunction ; Parenteral nutrition</subject><ispartof>Journal of pediatric surgery, 2021-04, Vol.56 (4), p.738-744</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-f647bb6bc0220d2c5df118c14314081d76e05f5b35156c1824c34a6e8a2777043</citedby><cites>FETCH-LOGICAL-c368t-f647bb6bc0220d2c5df118c14314081d76e05f5b35156c1824c34a6e8a2777043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpedsurg.2020.06.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32732165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Nan</creatorcontrib><creatorcontrib>Wang, Jiazheng</creatorcontrib><creatorcontrib>Zhang, Tian</creatorcontrib><creatorcontrib>Huang, Liufang</creatorcontrib><creatorcontrib>Yan, Weihui</creatorcontrib><creatorcontrib>Lu, Lina</creatorcontrib><creatorcontrib>Jia, Jie</creatorcontrib><creatorcontrib>Tao, Yijing</creatorcontrib><creatorcontrib>Cai, Wei</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><title>Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD.
Male 4-week-old Sprague Dawley rats received either total parenteral nutrition or standard chow with 0.9% saline for 7 days. The taxonomic composition of cecal microbiota and its functional composition associated with bile acid metabolism were measured.
There were differences in taxonomic composition between the two groups. The abundance of the secondary bile acid biosynthesis pathway was higher in the TPN group (p < 0.05) with an increase in the percentage of bacteria expressing 7-alpha-hydroxysteroid dehydrogenase (p < 0.05). The abundance of enzymes associated with bile salt hydrolase was also higher (p < 0.05) in the TPN group. The TPN group showed a distinct bile acid profile characterized by a higher ratio of secondary bile acids to primary bile acids.
The alteration of bile acid-associated microbiota may lead to increased secondary bile acid production in a rat model of PNALD.</description><subject>Bile acid profile</subject><subject>Cecal microbiome</subject><subject>Liver dysfunction</subject><subject>Parenteral nutrition</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOHDEQRa0oCIbHLyAv2XSn_G52IBQgElI2ydpy29XEo34Mtpsofx-PBqLsWNkqnbqlewi5ZNAyYPrLtt3uMOQ1PbccOLSgWxDqE9kwJVijQJjPZAPAeSOk7k7Iac5bgDoGdkxOBDeCM602pNyOBZMrcZkzXQb6vBY6RZ-WPi7FUTcHmjGtE-3jiNT5GDJ1qf5yXnx0BQP9HcsvuqvDeZ800nktKe4Dm_-gMb5ioiFmdBnPydHgxowXb-8Z-Xn_9cfdY_P0_eHb3e1T44XuSjNoafpe977WgMC9CgNjnWdSMAkdC0YjqEH1QjGlPeu49EI6jZ3jxhiQ4oxcHXJ3aXlZMRc7xexxHN2My5otl_zaGKmBV1Qf0Fo954SD3aU4ufTHMrB743Zr343bvXEL2lbjdfHy7cbaTxj-rb0rrsDNAcDa9DVistlHnD2GmNAXG5b40Y2_ksSW-g</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Wang, Nan</creator><creator>Wang, Jiazheng</creator><creator>Zhang, Tian</creator><creator>Huang, Liufang</creator><creator>Yan, Weihui</creator><creator>Lu, Lina</creator><creator>Jia, Jie</creator><creator>Tao, Yijing</creator><creator>Cai, Wei</creator><creator>Wang, Ying</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202104</creationdate><title>Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease</title><author>Wang, Nan ; Wang, Jiazheng ; Zhang, Tian ; Huang, Liufang ; Yan, Weihui ; Lu, Lina ; Jia, Jie ; Tao, Yijing ; Cai, Wei ; Wang, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-f647bb6bc0220d2c5df118c14314081d76e05f5b35156c1824c34a6e8a2777043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bile acid profile</topic><topic>Cecal microbiome</topic><topic>Liver dysfunction</topic><topic>Parenteral nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Nan</creatorcontrib><creatorcontrib>Wang, Jiazheng</creatorcontrib><creatorcontrib>Zhang, Tian</creatorcontrib><creatorcontrib>Huang, Liufang</creatorcontrib><creatorcontrib>Yan, Weihui</creatorcontrib><creatorcontrib>Lu, Lina</creatorcontrib><creatorcontrib>Jia, Jie</creatorcontrib><creatorcontrib>Tao, Yijing</creatorcontrib><creatorcontrib>Cai, Wei</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Nan</au><au>Wang, Jiazheng</au><au>Zhang, Tian</au><au>Huang, Liufang</au><au>Yan, Weihui</au><au>Lu, Lina</au><au>Jia, Jie</au><au>Tao, Yijing</au><au>Cai, Wei</au><au>Wang, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>2021-04</date><risdate>2021</risdate><volume>56</volume><issue>4</issue><spage>738</spage><epage>744</epage><pages>738-744</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><abstract>Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD.
Male 4-week-old Sprague Dawley rats received either total parenteral nutrition or standard chow with 0.9% saline for 7 days. The taxonomic composition of cecal microbiota and its functional composition associated with bile acid metabolism were measured.
There were differences in taxonomic composition between the two groups. The abundance of the secondary bile acid biosynthesis pathway was higher in the TPN group (p < 0.05) with an increase in the percentage of bacteria expressing 7-alpha-hydroxysteroid dehydrogenase (p < 0.05). The abundance of enzymes associated with bile salt hydrolase was also higher (p < 0.05) in the TPN group. The TPN group showed a distinct bile acid profile characterized by a higher ratio of secondary bile acids to primary bile acids.
The alteration of bile acid-associated microbiota may lead to increased secondary bile acid production in a rat model of PNALD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32732165</pmid><doi>10.1016/j.jpedsurg.2020.06.035</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bile acid profile Cecal microbiome Liver dysfunction Parenteral nutrition |
| title | Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease |
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