Downregulation of CYLD promotes IFN-γ mediated PD-L1 expression in thymic epithelial tumors

•The cylindromatosis (CYLD) gene is a crucial regulator of immune response.•CYLD mutations are associated with high PD-L1 expression in thymic carcinoma.•CYLD knockdown significantly enhanced the expression of PD-L1 in presence of IFN-γ stimulation in most TET cell lines.•There was a significant ass...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2020-09, Vol.147, p.221-228
Hauptverfasser:	Umemura, Shigeki, Zhu, Jianquan, Chahine, Joeffrey J., Kallakury, Bhaskar, Chen, Vincent, Kim, In-Kyu, Zhang, Yu-Wen, Goto, Koichi, He, Yongfeng, Giaccone, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - genetics B7-H1 Antigen - metabolism CYLD Deubiquitinating Enzyme CYLD - genetics Down-Regulation Humans IFN-γ Immune-checkpoint inhibitor Interferon-gamma - metabolism Lung Neoplasms Neoplasms, Glandular and Epithelial PD-L1 Thymic cancer Thymoma Thymus Neoplasms - genetics
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