SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic 1 , 2 . Clinical manifestations of COVID-19 vary, ranging from asymptomatic infection to respiratory failure. The mechanisms that determine such variable outcome...

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Veröffentlicht in:	Nature (London) 2020-11, Vol.587 (7833), p.270-274
Hauptverfasser:	Braun, Julian, Loyal, Lucie, Frentsch, Marco, Wendisch, Daniel, Georg, Philipp, Kurth, Florian, Hippenstiel, Stefan, Dingeldey, Manuela, Kruse, Beate, Fauchere, Florent, Baysal, Emre, Mangold, Maike, Henze, Larissa, Lauster, Roland, Mall, Marcus A., Beyer, Kirsten, Röhmel, Jobst, Voigt, Sebastian, Schmitz, Jürgen, Miltenyi, Stefan, Demuth, Ilja, Müller, Marcel A., Hocke, Andreas, Witzenrath, Martin, Suttorp, Norbert, Kern, Florian, Reimer, Ulf, Wenschuh, Holger, Drosten, Christian, Corman, Victor M., Giesecke-Thiel, Claudia, Sander, Leif Erik, Thiel, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/31 14 631/250/2152/1566/1571 631/326/596/4130 692/699/255/2514 Adult Aged Aged, 80 and over Amino acids Analysis Antibodies Antigens Asymptomatic Asymptomatic infection Betacoronavirus - immunology CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Line Cell lines Clinical trials Control Coronaviridae Coronavirus 229E, Human - immunology Coronavirus Infections - immunology Coronavirus NL63, Human - immunology Coronavirus OC43, Human - immunology Coronaviruses COVID-19 COVID-19 vaccines Cross Reactions Epitopes Epitopes, T-Lymphocyte - immunology Female Genetic aspects Glycoproteins Health care Healthy Volunteers Homology Humanities and Social Sciences Humans Infections Lymphocyte Activation Lymphocytes Lymphocytes T Male Middle Aged multidisciplinary Organ donors Pandemics Peptides Peripheral blood Pneumonia, Viral - immunology Proteins Respiratory diseases Respiratory failure SARS-CoV-2 Science Science (multidisciplinary) Serology Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Spike Glycoprotein, Coronavirus - immunology Spike protein T cell receptors T cells Viral diseases
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