Nanolipoidal α-Terpineol Modulates Quorum Sensing Regulated Virulence and Biofilm Formation in Pseudomonas Aeruginosa
Aim:Pseudomonas aeruginosa has emerged as a major opportunistic pathogen meaning there is an immediate need to develop efficient antivirulence agents which offer a new class of superior therapeutics. Methods: Nanostructured lipid carriers (NLCs) containing α-terpineol (αT) were developed and charact...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2020-08, Vol.15 (18), p.1743-1760 |
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| creator | Bose, Sunil Kumar Nirbhavane, Pradip Batra, Mahak Chhibber, Sanjay Harjai, Kusum |
| description | Aim:Pseudomonas aeruginosa has emerged as a major opportunistic pathogen meaning there is an immediate need to develop efficient antivirulence agents which offer a new class of superior therapeutics. Methods: Nanostructured lipid carriers (NLCs) containing α-terpineol (αT) were developed and characterized to determine expression profiles of quorum sensing regulated genes, antivirulence activity and antibiofilm effects against P. aeruginosa. Results: The αT-NLCs had a size of 145.4 nm, polydispersity index of 0.242 and ζ-potential of -31.4 mV. They exhibited pronounced effects on the inhibition of quorum sensing mediated virulence and biofilm formation which were confirmed by molecular docking analysis and gene expression profiles. Conclusion: αT-NLCs show promise as effective antivirulence agents against P. aeruginosa in the postantibiotic era. |
| doi_str_mv | 10.2217/nnm-2020-0134 |
| format | Article |
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| subjects | Antimicrobial agents Bacteria Biofilms Biosensors Dilution Drug dosages Drug resistance Infections Infectious diseases Lipids Microemulsions Morphology Oils & fats Virulence |
| title | Nanolipoidal α-Terpineol Modulates Quorum Sensing Regulated Virulence and Biofilm Formation in Pseudomonas Aeruginosa |
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