Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6

•Spinal cord compression at the L1 segment induced mechanical hindpaw pain in mice.•Compression-induced remote mechanical pain involved STAT3 and reactive astrocytes.•Neutralizing interleukin-6 in the compressed spinal cord reversed the remote pain.•Compression-induced remote mechanical pain involve...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2020-10, Vol.89, p.389-399
Hauptverfasser:	Ono, Teruaki, Kohro, Yuta, Kohno, Keita, Tozaki-Saitoh, Hidetoshi, Nakashima, Yasuharu, Tsuda, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Astrocytes - metabolism Dorsal horn Humans Hyperalgesia IL-6 Interleukin-6 - metabolism Lower Extremity Mechanical pain Pain Spinal Cord - metabolism Spinal cord compression STAT3 STAT3 Transcription Factor - metabolism
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