Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity
Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectro...
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| Veröffentlicht in: | Journal of inorganic biochemistry 2020-09, Vol.210, p.111160-111160, Article 111160 |
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| creator | Smolko, Lukáš Smolková, Romana Samoľová, Erika Morgan, Ibrahim Saoud, Mohamad Kaluđerović, Goran N. |
| description | Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy. Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected. |
| doi_str_mv | 10.1016/j.jinorgbio.2020.111160 |
| format | Article |
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Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2020.111160</identifier><identifier>PMID: 32717439</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-cancer ; Apoptosis ; Cobalt(II) complexes ; Flufenamic acid ; Niflumic acid ; NSAID</subject><ispartof>Journal of inorganic biochemistry, 2020-09, Vol.210, p.111160-111160, Article 111160</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-f883cd53071c2ceba37752a3a91b948bc8df9ab38b1c0437da8a4f802a3240eb3</citedby><cites>FETCH-LOGICAL-c371t-f883cd53071c2ceba37752a3a91b948bc8df9ab38b1c0437da8a4f802a3240eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinorgbio.2020.111160$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32717439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smolko, Lukáš</creatorcontrib><creatorcontrib>Smolková, Romana</creatorcontrib><creatorcontrib>Samoľová, Erika</creatorcontrib><creatorcontrib>Morgan, Ibrahim</creatorcontrib><creatorcontrib>Saoud, Mohamad</creatorcontrib><creatorcontrib>Kaluđerović, Goran N.</creatorcontrib><title>Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy. Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected.</description><subject>Anti-cancer</subject><subject>Apoptosis</subject><subject>Cobalt(II) complexes</subject><subject>Flufenamic acid</subject><subject>Niflumic acid</subject><subject>NSAID</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkEtvGyEQgFHVqHGT_oWWY3pYh5cN7s2y-rAUqZfkjIAdEqxdcIFN4kt-e0md5FouI2a-YYYPoS-UzCmhy8vdfBdiyrc2pDkjrGXbWZJ3aEaV5B3nQrxHs0ayjlAuTtHHUnaEkMVCyA_olDNJpeCrGXq6fkg4lFRqnlydshnwJl1st1-xHyYP0YymJmxij2NomX83l8b9AI9Q8EOod9iaepfctM8pRPiG19EM6XZ6rRrcB-8hQ6zYHWqq6TE4bFwN96EeztGJN0OBTy_xDN38-H69-dVd_f653ayvOsclrZ1Xirt-wYmkjjmwhku5YIabFbUroaxTvV8Zy5Wljggue6OM8Io0hAkClp-hi-O7bcs_bbeqx1AcDIOJkKaimWCKLBsrGyqPqMuplAxe73MYTT5oSvSzfL3Tb_L1s3x9lN86P78MmewI_Vvfq-0GrI8AtK_eB8i6uADRQR8yuKr7FP475C-XG5zU</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Smolko, Lukáš</creator><creator>Smolková, Romana</creator><creator>Samoľová, Erika</creator><creator>Morgan, Ibrahim</creator><creator>Saoud, Mohamad</creator><creator>Kaluđerović, Goran N.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity</title><author>Smolko, Lukáš ; Smolková, Romana ; Samoľová, Erika ; Morgan, Ibrahim ; Saoud, Mohamad ; Kaluđerović, Goran N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-f883cd53071c2ceba37752a3a91b948bc8df9ab38b1c0437da8a4f802a3240eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anti-cancer</topic><topic>Apoptosis</topic><topic>Cobalt(II) complexes</topic><topic>Flufenamic acid</topic><topic>Niflumic acid</topic><topic>NSAID</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smolko, Lukáš</creatorcontrib><creatorcontrib>Smolková, Romana</creatorcontrib><creatorcontrib>Samoľová, Erika</creatorcontrib><creatorcontrib>Morgan, Ibrahim</creatorcontrib><creatorcontrib>Saoud, Mohamad</creatorcontrib><creatorcontrib>Kaluđerović, Goran N.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smolko, Lukáš</au><au>Smolková, Romana</au><au>Samoľová, Erika</au><au>Morgan, Ibrahim</au><au>Saoud, Mohamad</au><au>Kaluđerović, Goran N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2020-09</date><risdate>2020</risdate><volume>210</volume><spage>111160</spage><epage>111160</epage><pages>111160-111160</pages><artnum>111160</artnum><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>Two novel Co(II) fenamato complexes containing bathocuproine (bcp), namely [Co(bcp)(flu)2] (1) and [Co(bcp)(nif)2] (2) (flu = flufenamato, nif = niflumato) were synthesized and characterized by elemental analysis, single-crystal X-ray structure analysis as well as absorption and fluorescence spectroscopy. Investigation of their molecular structure revealed that both complexes are isostructural and form analogous complex molecules, with a Co(II) atom hexacoordinated by two nitrogen atoms of bcp and four oxygen atoms of two chelate bonded flu (1) and nif (2) ligands in a distorted octahedral arrangement. Surprisingly, the results of cytotoxicity experiments on four cancer cell lines (HeLa, HT-29, PC-3 and MCF-7) have revealed that despite similar structure of the complexes, the nif complex exhibits significantly higher activity, being the most effective against the PC-3 cell line (IC50 (MTT) = 6.11 ± 1.95 μM). Further studies performed on PC-3 cell line have shown that the mechanism of the cytotoxic action of nif complex (2) might involve activation of autophagic processes and apoptosis, while for its flu analogue (1) apoptosis was detected.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32717439</pmid><doi>10.1016/j.jinorgbio.2020.111160</doi><tpages>1</tpages></addata></record> |
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| subjects | Anti-cancer Apoptosis Cobalt(II) complexes Flufenamic acid Niflumic acid NSAID |
| title | Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity |
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