Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats
Background Bariatric surgeries have been shown to be effective in reversing damaged pulmonary function in individuals suffering from obesity and type 2 diabetes mellitus, whereas its underlying mechanisms remain largely unknown. Methods Sleeve gastrectomy (SG) was performed on obese and diabetic Wis...
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| Veröffentlicht in: | International Journal of Obesity 2020-12, Vol.44 (12), p.2394-2404 |
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| container_title | International Journal of Obesity |
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| creator | Ruze, Rexiati Li, Jianwen Xu, Qian Zhong, Mingwei Xiong, Yacheng Yan, Zhibo Zhu, Jiankang Cheng, Yugang Ma, Zhe Hu, Sanyuan Zhang, Guangyong |
| description | Background
Bariatric surgeries have been shown to be effective in reversing damaged pulmonary function in individuals suffering from obesity and type 2 diabetes mellitus, whereas its underlying mechanisms remain largely unknown.
Methods
Sleeve gastrectomy (SG) was performed on obese and diabetic Wistar rats, and their pulmonary function and lung tissues were compared to sham-operated (SH) obese and diabetic rats, and age-matched healthy controls (C) to explore the improvements in microstructures and expression of surfactant protein (SP)-A and -C at postoperative 4th, 8th, and 12th week.
Result
Apart from the profound metabolic changes and improvement in pulmonary function, lung volume was restored along with an improved diffusion capacity noted by thinned capillary basement membrane and decreased harmonic mean length of diffusion barrier in SG rats. The digital slices of light microscope showed the general changes brought on by the SG, including normalized basic structures, ameliorated inflammatory status, as well as reduced lipid deposition, where the hydroxyproline (HYP), triglyceride (TG) assays, and electron microscope further suggested that the improvement in alveolar structures lies in reduced collagen fibers, lipids and septal tissues, increased capillary blood, and normalized alveolar type 2 (AT2) cells. Besides, disrupted SP-A and SP-C expression were also normalized after SG.
Conclusion
The improvement of lung function after SG is related to the ameliorated alveolar structures, and surface protein expression induced by weight loss and improved glucose metabolism. |
| doi_str_mv | 10.1038/s41366-020-0647-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2428060696</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650855240</galeid><sourcerecordid>A650855240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-c999f7862e67e7bab31e0b1963495a3768632fae91ed503464317afb0472352c3</originalsourceid><addsrcrecordid>eNp1kl1rFDEUhoModl39Ad5IQBBvpp58z1yW4hcUvFCvQyZ7ZjslM1mTTOn--2bdaq0ouQg553lfzgkvIS8ZnDIQ7bssmdC6AQ4NaGma_SOyYtLoRsnOPCYrEGAaUFqdkGc5XwGAUsCfkhPBDeuk4Cty8zUgXiPdulwS-hKnPXUThjEmVzBTF64xBpdobS--LOlQmzc0L2lwvri50F2KBceZ4s2udvMYZ1pfYZm3mcaBxh4z_tRsRtdjGT2t1vk5eTK4kPHF3b0m3z-8_3b-qbn48vHz-dlF45XQpfFd1w2m1Ry1QdO7XjCEnnVayE45YXSrBR8cdgw3CoTUUjDjhh6k4UJxL9bk7dG3jvljwVzsNGaPIbgZ45Itl7wFDbo6rsnrv9CruKS5TlcpIzjnwNp7ausC2nEeYknOH0ztmVbQKsUlVOr0H1Q9G5xGH2ccxlp_IHjzh-ASXSiXOYal1P_MD0F2BH2KOScc7C6Nk0t7y8AeYmGPsbA1FvYQC7uvmld3my39hJvfil85qAA_Arm25i2m-9X_73oLIfjBsg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2473222018</pqid></control><display><type>article</type><title>Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats</title><source>SpringerLink Journals</source><source>Nature Journals Online</source><creator>Ruze, Rexiati ; Li, Jianwen ; Xu, Qian ; Zhong, Mingwei ; Xiong, Yacheng ; Yan, Zhibo ; Zhu, Jiankang ; Cheng, Yugang ; Ma, Zhe ; Hu, Sanyuan ; Zhang, Guangyong</creator><creatorcontrib>Ruze, Rexiati ; Li, Jianwen ; Xu, Qian ; Zhong, Mingwei ; Xiong, Yacheng ; Yan, Zhibo ; Zhu, Jiankang ; Cheng, Yugang ; Ma, Zhe ; Hu, Sanyuan ; Zhang, Guangyong</creatorcontrib><description>Background
Bariatric surgeries have been shown to be effective in reversing damaged pulmonary function in individuals suffering from obesity and type 2 diabetes mellitus, whereas its underlying mechanisms remain largely unknown.
Methods
Sleeve gastrectomy (SG) was performed on obese and diabetic Wistar rats, and their pulmonary function and lung tissues were compared to sham-operated (SH) obese and diabetic rats, and age-matched healthy controls (C) to explore the improvements in microstructures and expression of surfactant protein (SP)-A and -C at postoperative 4th, 8th, and 12th week.
Result
Apart from the profound metabolic changes and improvement in pulmonary function, lung volume was restored along with an improved diffusion capacity noted by thinned capillary basement membrane and decreased harmonic mean length of diffusion barrier in SG rats. The digital slices of light microscope showed the general changes brought on by the SG, including normalized basic structures, ameliorated inflammatory status, as well as reduced lipid deposition, where the hydroxyproline (HYP), triglyceride (TG) assays, and electron microscope further suggested that the improvement in alveolar structures lies in reduced collagen fibers, lipids and septal tissues, increased capillary blood, and normalized alveolar type 2 (AT2) cells. Besides, disrupted SP-A and SP-C expression were also normalized after SG.
Conclusion
The improvement of lung function after SG is related to the ameliorated alveolar structures, and surface protein expression induced by weight loss and improved glucose metabolism.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-020-0647-y</identifier><identifier>PMID: 32719432</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/28 ; 13/105 ; 13/106 ; 14/63 ; 38/1 ; 38/79 ; 631/443/319/1642/393 ; 692/163/2743/137/138 ; 82/1 ; 82/79 ; 82/80 ; 96/63 ; Alveoli ; Body weight loss ; Care and treatment ; Collagen ; Complications and side effects ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diffusion barriers ; Epidemiology ; Gastrectomy ; Gastrointestinal surgery ; Glucose metabolism ; Health Promotion and Disease Prevention ; Hydroxyproline ; Inflammation ; Internal Medicine ; Lipids ; Lungs ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Physiological aspects ; Protein expression ; Proteins ; Public Health ; Pulmonary functions ; Respiratory function ; Respiratory tract diseases ; Risk factors ; Rodents ; Surfactants ; Surgery ; Triglycerides ; Type 2 diabetes ; Weight loss</subject><ispartof>International Journal of Obesity, 2020-12, Vol.44 (12), p.2394-2404</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>The Author(s), under exclusive licence to Springer Nature Limited 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-c999f7862e67e7bab31e0b1963495a3768632fae91ed503464317afb0472352c3</citedby><cites>FETCH-LOGICAL-c536t-c999f7862e67e7bab31e0b1963495a3768632fae91ed503464317afb0472352c3</cites><orcidid>0000-0001-5308-0129 ; 0000-0002-0891-5307</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-020-0647-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-020-0647-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32719432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruze, Rexiati</creatorcontrib><creatorcontrib>Li, Jianwen</creatorcontrib><creatorcontrib>Xu, Qian</creatorcontrib><creatorcontrib>Zhong, Mingwei</creatorcontrib><creatorcontrib>Xiong, Yacheng</creatorcontrib><creatorcontrib>Yan, Zhibo</creatorcontrib><creatorcontrib>Zhu, Jiankang</creatorcontrib><creatorcontrib>Cheng, Yugang</creatorcontrib><creatorcontrib>Ma, Zhe</creatorcontrib><creatorcontrib>Hu, Sanyuan</creatorcontrib><creatorcontrib>Zhang, Guangyong</creatorcontrib><title>Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
Bariatric surgeries have been shown to be effective in reversing damaged pulmonary function in individuals suffering from obesity and type 2 diabetes mellitus, whereas its underlying mechanisms remain largely unknown.
Methods
Sleeve gastrectomy (SG) was performed on obese and diabetic Wistar rats, and their pulmonary function and lung tissues were compared to sham-operated (SH) obese and diabetic rats, and age-matched healthy controls (C) to explore the improvements in microstructures and expression of surfactant protein (SP)-A and -C at postoperative 4th, 8th, and 12th week.
Result
Apart from the profound metabolic changes and improvement in pulmonary function, lung volume was restored along with an improved diffusion capacity noted by thinned capillary basement membrane and decreased harmonic mean length of diffusion barrier in SG rats. The digital slices of light microscope showed the general changes brought on by the SG, including normalized basic structures, ameliorated inflammatory status, as well as reduced lipid deposition, where the hydroxyproline (HYP), triglyceride (TG) assays, and electron microscope further suggested that the improvement in alveolar structures lies in reduced collagen fibers, lipids and septal tissues, increased capillary blood, and normalized alveolar type 2 (AT2) cells. Besides, disrupted SP-A and SP-C expression were also normalized after SG.
Conclusion
The improvement of lung function after SG is related to the ameliorated alveolar structures, and surface protein expression induced by weight loss and improved glucose metabolism.</description><subject>101/28</subject><subject>13/105</subject><subject>13/106</subject><subject>14/63</subject><subject>38/1</subject><subject>38/79</subject><subject>631/443/319/1642/393</subject><subject>692/163/2743/137/138</subject><subject>82/1</subject><subject>82/79</subject><subject>82/80</subject><subject>96/63</subject><subject>Alveoli</subject><subject>Body weight loss</subject><subject>Care and treatment</subject><subject>Collagen</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diffusion barriers</subject><subject>Epidemiology</subject><subject>Gastrectomy</subject><subject>Gastrointestinal surgery</subject><subject>Glucose metabolism</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hydroxyproline</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Lungs</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Public Health</subject><subject>Pulmonary functions</subject><subject>Respiratory function</subject><subject>Respiratory tract diseases</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Surfactants</subject><subject>Surgery</subject><subject>Triglycerides</subject><subject>Type 2 diabetes</subject><subject>Weight 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gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats</title><author>Ruze, Rexiati ; Li, Jianwen ; Xu, Qian ; Zhong, Mingwei ; Xiong, Yacheng ; Yan, Zhibo ; Zhu, Jiankang ; Cheng, Yugang ; Ma, Zhe ; Hu, Sanyuan ; Zhang, Guangyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-c999f7862e67e7bab31e0b1963495a3768632fae91ed503464317afb0472352c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>101/28</topic><topic>13/105</topic><topic>13/106</topic><topic>14/63</topic><topic>38/1</topic><topic>38/79</topic><topic>631/443/319/1642/393</topic><topic>692/163/2743/137/138</topic><topic>82/1</topic><topic>82/79</topic><topic>82/80</topic><topic>96/63</topic><topic>Alveoli</topic><topic>Body weight loss</topic><topic>Care and treatment</topic><topic>Collagen</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diffusion barriers</topic><topic>Epidemiology</topic><topic>Gastrectomy</topic><topic>Gastrointestinal surgery</topic><topic>Glucose metabolism</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hydroxyproline</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Lungs</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Physiological aspects</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Public Health</topic><topic>Pulmonary functions</topic><topic>Respiratory function</topic><topic>Respiratory tract diseases</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Surfactants</topic><topic>Surgery</topic><topic>Triglycerides</topic><topic>Type 2 diabetes</topic><topic>Weight 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Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruze, Rexiati</au><au>Li, Jianwen</au><au>Xu, Qian</au><au>Zhong, Mingwei</au><au>Xiong, Yacheng</au><au>Yan, Zhibo</au><au>Zhu, Jiankang</au><au>Cheng, Yugang</au><au>Ma, Zhe</au><au>Hu, Sanyuan</au><au>Zhang, Guangyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>44</volume><issue>12</issue><spage>2394</spage><epage>2404</epage><pages>2394-2404</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background
Bariatric surgeries have been shown to be effective in reversing damaged pulmonary function in individuals suffering from obesity and type 2 diabetes mellitus, whereas its underlying mechanisms remain largely unknown.
Methods
Sleeve gastrectomy (SG) was performed on obese and diabetic Wistar rats, and their pulmonary function and lung tissues were compared to sham-operated (SH) obese and diabetic rats, and age-matched healthy controls (C) to explore the improvements in microstructures and expression of surfactant protein (SP)-A and -C at postoperative 4th, 8th, and 12th week.
Result
Apart from the profound metabolic changes and improvement in pulmonary function, lung volume was restored along with an improved diffusion capacity noted by thinned capillary basement membrane and decreased harmonic mean length of diffusion barrier in SG rats. The digital slices of light microscope showed the general changes brought on by the SG, including normalized basic structures, ameliorated inflammatory status, as well as reduced lipid deposition, where the hydroxyproline (HYP), triglyceride (TG) assays, and electron microscope further suggested that the improvement in alveolar structures lies in reduced collagen fibers, lipids and septal tissues, increased capillary blood, and normalized alveolar type 2 (AT2) cells. Besides, disrupted SP-A and SP-C expression were also normalized after SG.
Conclusion
The improvement of lung function after SG is related to the ameliorated alveolar structures, and surface protein expression induced by weight loss and improved glucose metabolism.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32719432</pmid><doi>10.1038/s41366-020-0647-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5308-0129</orcidid><orcidid>https://orcid.org/0000-0002-0891-5307</orcidid></addata></record> |
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| source | SpringerLink Journals; Nature Journals Online |
| subjects | 101/28 13/105 13/106 14/63 38/1 38/79 631/443/319/1642/393 692/163/2743/137/138 82/1 82/79 82/80 96/63 Alveoli Body weight loss Care and treatment Collagen Complications and side effects Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diffusion barriers Epidemiology Gastrectomy Gastrointestinal surgery Glucose metabolism Health Promotion and Disease Prevention Hydroxyproline Inflammation Internal Medicine Lipids Lungs Medicine Medicine & Public Health Metabolic Diseases Obesity Physiological aspects Protein expression Proteins Public Health Pulmonary functions Respiratory function Respiratory tract diseases Risk factors Rodents Surfactants Surgery Triglycerides Type 2 diabetes Weight loss |
| title | Sleeve gastrectomy ameliorates alveolar structures and surfactant protein expression in lungs of obese and diabetic rats |
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