Altered spatiotemporal consistency of corticolimbic circuitry in euthymic pediatric bipolar disorder
Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in ped...
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| description | Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study. Voxel-wised correlation between clinical and cognitive indices and FOCA in PBD was calculated.Compared with healthy subjects, euthymic PBD patients showed worse performance in tests of Stroop Color-Word Test, Digit Span Test and Trail Making Test. Euthymic PBD patients demonstrated increased FOCA in left inferior frontal gyrus, left anterior cingulate cortex and left superior frontal gyrus and decreased FOCA in right orbital frontal gyrus, bilateral precuneus, right superior occipital gyrus and bilateral superior parietal gyrus. Decreased functional connectivities were found between right orbital frontal gyrus and left amygdala, between left superior frontal gyrus and left putamen, and between left superior frontal gyrus and left insula. And increased functional connectivity was found between right superior occipital gyrus and right hippocampus. FOCA of parahippocampal gyrus was negatively correlated with the SCWT-B score in PBD patients.Abnormal spatiotemporal consistency of brain regions of corticolimbic circuitry is possible to contribute to an imbalance between emotional processing and cognitive control in euthymic PBD. The measurement of FOCA measure may provide important clues of understanding PBD. |
| doi_str_mv | 10.1007/s11682-020-00327-1 |
| format | Article |
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It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study. Voxel-wised correlation between clinical and cognitive indices and FOCA in PBD was calculated.Compared with healthy subjects, euthymic PBD patients showed worse performance in tests of Stroop Color-Word Test, Digit Span Test and Trail Making Test. Euthymic PBD patients demonstrated increased FOCA in left inferior frontal gyrus, left anterior cingulate cortex and left superior frontal gyrus and decreased FOCA in right orbital frontal gyrus, bilateral precuneus, right superior occipital gyrus and bilateral superior parietal gyrus. Decreased functional connectivities were found between right orbital frontal gyrus and left amygdala, between left superior frontal gyrus and left putamen, and between left superior frontal gyrus and left insula. And increased functional connectivity was found between right superior occipital gyrus and right hippocampus. FOCA of parahippocampal gyrus was negatively correlated with the SCWT-B score in PBD patients.Abnormal spatiotemporal consistency of brain regions of corticolimbic circuitry is possible to contribute to an imbalance between emotional processing and cognitive control in euthymic PBD. The measurement of FOCA measure may provide important clues of understanding PBD.</description><identifier>ISSN: 1931-7557</identifier><identifier>EISSN: 1931-7565</identifier><identifier>DOI: 10.1007/s11682-020-00327-1</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amygdala ; Biomedical and Life Sciences ; Biomedicine ; Bipolar disorder ; Brain ; Brain mapping ; Circuits ; Cognitive ability ; Consistency ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Frontal gyrus ; Functional magnetic resonance imaging ; Information processing ; Mathematical analysis ; Neural networks ; Neuropsychology ; Neuroradiology ; Neurosciences ; Original Research ; Parahippocampal gyrus ; Patients ; Pediatrics ; Psychiatry ; Putamen ; Signal processing ; Temporal cortex</subject><ispartof>Brain imaging and behavior, 2021-06, Vol.15 (3), p.1290-1299</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-9c272a0c939f97967403162b3387e3cfc8eaba5953f033bb944f6f1a314986513</citedby><cites>FETCH-LOGICAL-c352t-9c272a0c939f97967403162b3387e3cfc8eaba5953f033bb944f6f1a314986513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11682-020-00327-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11682-020-00327-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Guo, Yongxin</creatorcontrib><creatorcontrib>Wang, Jinfeng</creatorcontrib><creatorcontrib>Jiao, Qing</creatorcontrib><creatorcontrib>Cao, Weifang</creatorcontrib><creatorcontrib>Cui, Dong</creatorcontrib><creatorcontrib>Gao, Weijia</creatorcontrib><creatorcontrib>Qiu, Jianfeng</creatorcontrib><creatorcontrib>Su, Linyan</creatorcontrib><creatorcontrib>Lu, Guangming</creatorcontrib><title>Altered spatiotemporal consistency of corticolimbic circuitry in euthymic pediatric bipolar disorder</title><title>Brain imaging and behavior</title><addtitle>Brain Imaging and Behavior</addtitle><description>Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study. Voxel-wised correlation between clinical and cognitive indices and FOCA in PBD was calculated.Compared with healthy subjects, euthymic PBD patients showed worse performance in tests of Stroop Color-Word Test, Digit Span Test and Trail Making Test. Euthymic PBD patients demonstrated increased FOCA in left inferior frontal gyrus, left anterior cingulate cortex and left superior frontal gyrus and decreased FOCA in right orbital frontal gyrus, bilateral precuneus, right superior occipital gyrus and bilateral superior parietal gyrus. Decreased functional connectivities were found between right orbital frontal gyrus and left amygdala, between left superior frontal gyrus and left putamen, and between left superior frontal gyrus and left insula. And increased functional connectivity was found between right superior occipital gyrus and right hippocampus. FOCA of parahippocampal gyrus was negatively correlated with the SCWT-B score in PBD patients.Abnormal spatiotemporal consistency of brain regions of corticolimbic circuitry is possible to contribute to an imbalance between emotional processing and cognitive control in euthymic PBD. The measurement of FOCA measure may provide important clues of understanding PBD.</description><subject>Amygdala</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bipolar disorder</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Circuits</subject><subject>Cognitive ability</subject><subject>Consistency</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Frontal gyrus</subject><subject>Functional magnetic resonance imaging</subject><subject>Information processing</subject><subject>Mathematical analysis</subject><subject>Neural networks</subject><subject>Neuropsychology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Research</subject><subject>Parahippocampal gyrus</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Putamen</subject><subject>Signal processing</subject><subject>Temporal cortex</subject><issn>1931-7557</issn><issn>1931-7565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtKxDAUhoMoOI6-gKuCGzfVXJqmWQ6DNxhwo-uQpqlmaJt6ki769masKLhwdS585_DzIXRJ8A3BWNwGQsqK5pjiHGNGRU6O0IpIRnLBS37803Nxis5C2GPMi0qSFWo2XbRgmyyMOjofbT960F1m_BBciHYwc-bbNEJ0xneur53JjAMzuQhz5obMTvF97tN2tI3TEVJXu9F3GrLGBQ-NhXN00uou2Ivvukav93cv28d89_zwtN3scsM4jbk0VFCNjWSylUKWosCMlLRmrBKWmdZUVteaS85azFhdy6Joy5ZoRgpZlZywNbpe_o7gPyYboupdMLbr9GD9FBQtqOCUk4In9OoPuvcTDCmdojwxNEnEiaILZcCHALZVI7hew6wIVgfxahGvknj1JV4dUrDlKCR4eLPw-_qfq09O4oa3</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Guo, Yongxin</creator><creator>Wang, Jinfeng</creator><creator>Jiao, 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circuitry in euthymic pediatric bipolar disorder</title><author>Guo, Yongxin ; Wang, Jinfeng ; Jiao, Qing ; Cao, Weifang ; Cui, Dong ; Gao, Weijia ; Qiu, Jianfeng ; Su, Linyan ; Lu, Guangming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-9c272a0c939f97967403162b3387e3cfc8eaba5953f033bb944f6f1a314986513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amygdala</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bipolar disorder</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Circuits</topic><topic>Cognitive ability</topic><topic>Consistency</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Frontal gyrus</topic><topic>Functional magnetic resonance imaging</topic><topic>Information processing</topic><topic>Mathematical analysis</topic><topic>Neural 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Behavior</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>15</volume><issue>3</issue><spage>1290</spage><epage>1299</epage><pages>1290-1299</pages><issn>1931-7557</issn><eissn>1931-7565</eissn><abstract>Bipolar disorder (BD) is a life-threatening illness which clinically defined by an alternating pattern of depressive and manic episodes with a separated period of euthymia. It remains unknown about the consistency of temporal-spatial spontaneous brain activity in euthymic patients, especially in pediatric BD (PBD) patients.Resting-state fMRI signals of sixteen euthymic PBD patients and 16 healthy controls were processed and FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) and functional connectivity were calculated in the present study. Voxel-wised correlation between clinical and cognitive indices and FOCA in PBD was calculated.Compared with healthy subjects, euthymic PBD patients showed worse performance in tests of Stroop Color-Word Test, Digit Span Test and Trail Making Test. Euthymic PBD patients demonstrated increased FOCA in left inferior frontal gyrus, left anterior cingulate cortex and left superior frontal gyrus and decreased FOCA in right orbital frontal gyrus, bilateral precuneus, right superior occipital gyrus and bilateral superior parietal gyrus. Decreased functional connectivities were found between right orbital frontal gyrus and left amygdala, between left superior frontal gyrus and left putamen, and between left superior frontal gyrus and left insula. And increased functional connectivity was found between right superior occipital gyrus and right hippocampus. FOCA of parahippocampal gyrus was negatively correlated with the SCWT-B score in PBD patients.Abnormal spatiotemporal consistency of brain regions of corticolimbic circuitry is possible to contribute to an imbalance between emotional processing and cognitive control in euthymic PBD. The measurement of FOCA measure may provide important clues of understanding PBD.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11682-020-00327-1</doi><tpages>10</tpages></addata></record> |
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| subjects | Amygdala Biomedical and Life Sciences Biomedicine Bipolar disorder Brain Brain mapping Circuits Cognitive ability Consistency Cortex (cingulate) Cortex (frontal) Cortex (parietal) Frontal gyrus Functional magnetic resonance imaging Information processing Mathematical analysis Neural networks Neuropsychology Neuroradiology Neurosciences Original Research Parahippocampal gyrus Patients Pediatrics Psychiatry Putamen Signal processing Temporal cortex |
| title | Altered spatiotemporal consistency of corticolimbic circuitry in euthymic pediatric bipolar disorder |
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