Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway

The calcineurin (CaN)/nuclear factor of activated T-cell (NFAT) signalling pathway plays an important role in pathological cardiac hypertrophy. Here, we investigated the potential effects of stachydrine hydrochloride, a bioactive constituent extracted from the Chinese herb Leonurus japonicus Houtt....

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Veröffentlicht in:	European journal of pharmacology 2020-09, Vol.883, p.173386-173386, Article 173386
Hauptverfasser:	Zheng, Jiali, Tian, Jing, Wang, Sining, Hu, Panwei, Wu, Qianfu, Shan, Xiaoli, Zhao, Pei, Zhang, Chen, Guo, Wei, Xu, Ming, Chen, Huihua, Lu, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcineurin Calcineurin - metabolism Cells, Cultured Disease Models, Animal Gene Expression Regulation Hypertrophy, Left Ventricular - chemically induced Hypertrophy, Left Ventricular - enzymology Hypertrophy, Left Ventricular - physiopathology Hypertrophy, Left Ventricular - prevention & control Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology NFAT NFATC Transcription Factors - metabolism Pathological cardiac hypertrophy Phenylephrine Proline - analogs & derivatives Proline - pharmacology Rats, Wistar Signal Transduction Stachydrine hydrochloride Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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