Systemic cytokines/chemokines associated to radiographic abnormalities in pneumonia in children
•IL-6 was significantly higher among children with pneumococcal pneumonia.•IL-6 was significantly higher among children with pleural effusion.•IL-6 was independently associated with pleural effusion and pneumococcal infection.•High IL-6 is associated to pneumococcal infection if pleural effusion is...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2020-11, Vol.135, p.155191-155191, Article 155191 |
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| creator | Vasconcellos, Ângela G. Clarêncio, Jorge Andrade, Daniela Araújo-Neto, César A. Barral, Aldina Nascimento-Carvalho, Cristiana M. |
| description | •IL-6 was significantly higher among children with pneumococcal pneumonia.•IL-6 was significantly higher among children with pleural effusion.•IL-6 was independently associated with pleural effusion and pneumococcal infection.•High IL-6 is associated to pneumococcal infection if pleural effusion is absent.•IL-6 may be a pneumococcal infection biomarker if pleural effusion is absent.
Community-acquired pneumonia (CAP) diagnosis remains a challenge in paediatrics. Chest radiography is considered gold standard for definition of pneumonia, however no previous study assessed the relationship between immune response and radiographic-confirmed-pneumonia. We assessed association between cytokines/chemokines levels and radiographic abnormalities in children with CAP.
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| doi_str_mv | 10.1016/j.cyto.2020.155191 |
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Community-acquired pneumonia (CAP) diagnosis remains a challenge in paediatrics. Chest radiography is considered gold standard for definition of pneumonia, however no previous study assessed the relationship between immune response and radiographic-confirmed-pneumonia. We assessed association between cytokines/chemokines levels and radiographic abnormalities in children with CAP.
Children < 5-years-old hospitalized with CAP were investigated in a prospective study at the Federal University of Bahia Hospital, Brazil. On admission, clinical data and biological samples were collected to investigate 20 aetiological agents and determine serum cytokines/chemokines levels; chest radiographs were performed.
Among 158 patients, radiographic diagnosis of pneumonia was confirmed in 126(79.7%) and 17(10.8%) had pleural effusion. Viral, bacterial and pneumococcal infection were detected in 80(50.6%), 78(49.4%) and 37(23.4%) cases. By comparing the median concentrations of serum cytokines/chemokines between children with or without pleural effusion, interleukin(IL)-6 was higher (26.6[18.6–103.7] vs 3.0[0.0–19.8]; p < 0.001) among those with pleural effusion; and between children with or without radiographic-confirmed-pneumonia, IL-6 was higher in the first subgroup (4.5[0.0–23.4] vs 0.0[0.0–3.6]; p = 0.02) after having excluded cases with pleural effusion. Stratified analyses according to aetiology showed IL-6 increase in the radiographic-confirmed-pneumonia subgroup inside the pneumococcal infection (28.2[5.9–64.1] vs 0.0[0.0–0.0]; p = 0.03) subgroup. By multivariable analysis, with IL-6 as dependent variable, pneumococcal infection and pleural effusion showed independent association with IL-6 elevation [respective OR: 5.071 (95%CI = 2.226–11.548; p < 0.001) and 13.604 (95%CI = 3.463–53.449; p = 0.0001)]. Considering the cases without pleural effusion, the area under the curve of IL-6 to predict pneumococcal infection was 0.76 (95%CI = 0.66–0.86; p < 0.001).
IL-6 increase is a potential biomarker of pneumococcal infection among children with CAP without pleural effusion upon admission.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2020.155191</identifier><identifier>PMID: 32712459</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Bronchopneumonia ; Chest x-ray ; Immunity ; Lung diseases ; Lung inflammation ; Pulmonary inflammation ; Respiratory tract infections</subject><ispartof>Cytokine (Philadelphia, Pa.), 2020-11, Vol.135, p.155191-155191, Article 155191</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ba741f30e3dd6a4983404b95d612832d68a1bd3edb0bcbc6c47d45be214da9e83</citedby><cites>FETCH-LOGICAL-c356t-ba741f30e3dd6a4983404b95d612832d68a1bd3edb0bcbc6c47d45be214da9e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2020.155191$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32712459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasconcellos, Ângela G.</creatorcontrib><creatorcontrib>Clarêncio, Jorge</creatorcontrib><creatorcontrib>Andrade, Daniela</creatorcontrib><creatorcontrib>Araújo-Neto, César A.</creatorcontrib><creatorcontrib>Barral, Aldina</creatorcontrib><creatorcontrib>Nascimento-Carvalho, Cristiana M.</creatorcontrib><title>Systemic cytokines/chemokines associated to radiographic abnormalities in pneumonia in children</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>•IL-6 was significantly higher among children with pneumococcal pneumonia.•IL-6 was significantly higher among children with pleural effusion.•IL-6 was independently associated with pleural effusion and pneumococcal infection.•High IL-6 is associated to pneumococcal infection if pleural effusion is absent.•IL-6 may be a pneumococcal infection biomarker if pleural effusion is absent.
Community-acquired pneumonia (CAP) diagnosis remains a challenge in paediatrics. Chest radiography is considered gold standard for definition of pneumonia, however no previous study assessed the relationship between immune response and radiographic-confirmed-pneumonia. We assessed association between cytokines/chemokines levels and radiographic abnormalities in children with CAP.
Children < 5-years-old hospitalized with CAP were investigated in a prospective study at the Federal University of Bahia Hospital, Brazil. On admission, clinical data and biological samples were collected to investigate 20 aetiological agents and determine serum cytokines/chemokines levels; chest radiographs were performed.
Among 158 patients, radiographic diagnosis of pneumonia was confirmed in 126(79.7%) and 17(10.8%) had pleural effusion. Viral, bacterial and pneumococcal infection were detected in 80(50.6%), 78(49.4%) and 37(23.4%) cases. By comparing the median concentrations of serum cytokines/chemokines between children with or without pleural effusion, interleukin(IL)-6 was higher (26.6[18.6–103.7] vs 3.0[0.0–19.8]; p < 0.001) among those with pleural effusion; and between children with or without radiographic-confirmed-pneumonia, IL-6 was higher in the first subgroup (4.5[0.0–23.4] vs 0.0[0.0–3.6]; p = 0.02) after having excluded cases with pleural effusion. Stratified analyses according to aetiology showed IL-6 increase in the radiographic-confirmed-pneumonia subgroup inside the pneumococcal infection (28.2[5.9–64.1] vs 0.0[0.0–0.0]; p = 0.03) subgroup. By multivariable analysis, with IL-6 as dependent variable, pneumococcal infection and pleural effusion showed independent association with IL-6 elevation [respective OR: 5.071 (95%CI = 2.226–11.548; p < 0.001) and 13.604 (95%CI = 3.463–53.449; p = 0.0001)]. Considering the cases without pleural effusion, the area under the curve of IL-6 to predict pneumococcal infection was 0.76 (95%CI = 0.66–0.86; p < 0.001).
IL-6 increase is a potential biomarker of pneumococcal infection among children with CAP without pleural effusion upon admission.</description><subject>Bronchopneumonia</subject><subject>Chest x-ray</subject><subject>Immunity</subject><subject>Lung diseases</subject><subject>Lung inflammation</subject><subject>Pulmonary inflammation</subject><subject>Respiratory tract infections</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKw0AUhgdRbK2-gAvJ0k3auWWSgBsRb1Bwoa6HuZzaqUkmziRC396EVJeuzoXv_HA-hC4JXhJMxGq3NPvOLymmwyLLSEmO0JzgUqQYU3Y89pylXAgxQ2cx7jDGJcvzUzRjNCeUZ-Ucydd97KB2JhmzPl0DcWW2UE9tomL0xqkObNL5JCjr_EdQ7XbglW58qFXlOjeArknaBvraN06Ng9m6ygZoztHJRlURLg51gd4f7t_untL1y-Pz3e06NSwTXapVzsmGYWDWCsXLgnHMdZlZQWjBqBWFItoysBpro40wPLc800AJt6qEgi3Q9ZTbBv_VQ-xk7aKBqlIN-D5KymmeUZLn2YDSCTXBxxhgI9vgahX2kmA5ipU7OcqQo1g5iR2Org75va7B_p38mhyAmwmA4ctvB0FG46AxYF0A00nr3X_5PwgSi_A</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Vasconcellos, Ângela G.</creator><creator>Clarêncio, Jorge</creator><creator>Andrade, Daniela</creator><creator>Araújo-Neto, César A.</creator><creator>Barral, Aldina</creator><creator>Nascimento-Carvalho, Cristiana M.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202011</creationdate><title>Systemic cytokines/chemokines associated to radiographic abnormalities in pneumonia in children</title><author>Vasconcellos, Ângela G. ; Clarêncio, Jorge ; Andrade, Daniela ; Araújo-Neto, César A. ; Barral, Aldina ; Nascimento-Carvalho, Cristiana M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ba741f30e3dd6a4983404b95d612832d68a1bd3edb0bcbc6c47d45be214da9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bronchopneumonia</topic><topic>Chest x-ray</topic><topic>Immunity</topic><topic>Lung diseases</topic><topic>Lung inflammation</topic><topic>Pulmonary inflammation</topic><topic>Respiratory tract infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasconcellos, Ângela G.</creatorcontrib><creatorcontrib>Clarêncio, Jorge</creatorcontrib><creatorcontrib>Andrade, Daniela</creatorcontrib><creatorcontrib>Araújo-Neto, César A.</creatorcontrib><creatorcontrib>Barral, Aldina</creatorcontrib><creatorcontrib>Nascimento-Carvalho, Cristiana M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasconcellos, Ângela G.</au><au>Clarêncio, Jorge</au><au>Andrade, Daniela</au><au>Araújo-Neto, César A.</au><au>Barral, Aldina</au><au>Nascimento-Carvalho, Cristiana M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic cytokines/chemokines associated to radiographic abnormalities in pneumonia in children</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2020-11</date><risdate>2020</risdate><volume>135</volume><spage>155191</spage><epage>155191</epage><pages>155191-155191</pages><artnum>155191</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>•IL-6 was significantly higher among children with pneumococcal pneumonia.•IL-6 was significantly higher among children with pleural effusion.•IL-6 was independently associated with pleural effusion and pneumococcal infection.•High IL-6 is associated to pneumococcal infection if pleural effusion is absent.•IL-6 may be a pneumococcal infection biomarker if pleural effusion is absent.
Community-acquired pneumonia (CAP) diagnosis remains a challenge in paediatrics. Chest radiography is considered gold standard for definition of pneumonia, however no previous study assessed the relationship between immune response and radiographic-confirmed-pneumonia. We assessed association between cytokines/chemokines levels and radiographic abnormalities in children with CAP.
Children < 5-years-old hospitalized with CAP were investigated in a prospective study at the Federal University of Bahia Hospital, Brazil. On admission, clinical data and biological samples were collected to investigate 20 aetiological agents and determine serum cytokines/chemokines levels; chest radiographs were performed.
Among 158 patients, radiographic diagnosis of pneumonia was confirmed in 126(79.7%) and 17(10.8%) had pleural effusion. Viral, bacterial and pneumococcal infection were detected in 80(50.6%), 78(49.4%) and 37(23.4%) cases. By comparing the median concentrations of serum cytokines/chemokines between children with or without pleural effusion, interleukin(IL)-6 was higher (26.6[18.6–103.7] vs 3.0[0.0–19.8]; p < 0.001) among those with pleural effusion; and between children with or without radiographic-confirmed-pneumonia, IL-6 was higher in the first subgroup (4.5[0.0–23.4] vs 0.0[0.0–3.6]; p = 0.02) after having excluded cases with pleural effusion. Stratified analyses according to aetiology showed IL-6 increase in the radiographic-confirmed-pneumonia subgroup inside the pneumococcal infection (28.2[5.9–64.1] vs 0.0[0.0–0.0]; p = 0.03) subgroup. By multivariable analysis, with IL-6 as dependent variable, pneumococcal infection and pleural effusion showed independent association with IL-6 elevation [respective OR: 5.071 (95%CI = 2.226–11.548; p < 0.001) and 13.604 (95%CI = 3.463–53.449; p = 0.0001)]. Considering the cases without pleural effusion, the area under the curve of IL-6 to predict pneumococcal infection was 0.76 (95%CI = 0.66–0.86; p < 0.001).
IL-6 increase is a potential biomarker of pneumococcal infection among children with CAP without pleural effusion upon admission.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32712459</pmid><doi>10.1016/j.cyto.2020.155191</doi><tpages>1</tpages></addata></record> |
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| subjects | Bronchopneumonia Chest x-ray Immunity Lung diseases Lung inflammation Pulmonary inflammation Respiratory tract infections |
| title | Systemic cytokines/chemokines associated to radiographic abnormalities in pneumonia in children |
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